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Palbociclib (CUI C3853822) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C3853822

NCI Thesaurus Code: C49176  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.

PDQ Definition: An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonyms & Abbreviations: (see Synonym Details)
571190-30-2
6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
Ibrance
Palbociclib (substance)
Palbociclib
PD 0332991
PD-0332991
PD-332991
PD0332991

External Source Codes: 
NCI Thesaurus Code C49176 (see NCI Thesaurus info)
CAS Registry Number 571190-30-2 (see NLM ChemIDplus info)
FDA UNII Code G9ZF61LE7G
PDQ Closed Trial Search ID 454586
PDQ Open Trial Search ID 454586 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative advanced or metastatic breast cancer NCI
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C24H29N7O2 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUtBA SNOMEDCT_US
DATE_FIRST_PUBLISHED 2005-11-04 PDQ
DATE_LAST_MODIFIED 2015-03-20 PDQ
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20160731 SNOMEDCT_US
FDA_UNII_CODE G9ZF61LE7G DRUGBANK
FDA_UNII_CODE G9ZF61LE7G NDFRT
FR 114 MSH
HM D010879 MSH
HM D011725 MSH
II D018844 MSH
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 20050428 MSH
MMR 20150205 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C49176 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NUI N0000191426 NDFRT
ORIG_STY Drug/agent PDQ
PA D000970 MSH
PA D047428 MSH
RN 0 MSH
RN G9ZF61LE7G MSH
RXAUI 6827907 RXNORM
RXAUI 6827927 RXNORM
RXAUI 6827933 RXNORM
RXAUI 6838370 RXNORM
RXAUI 6840827 RXNORM
RXAUI 6840828 RXNORM
RXCUI 1601374 RXNORM
RXCUI 1601381 RXNORM
RXN_BN_CARDINALITY single RXNORM
SC 1 MSH
SOS has antineoplastic activity; specific inhibitor of cyclin-dependent kinases 4 & 6; structure in first source MSH
SPL_SET_ID 86718885-da44-4d3d-b3ca-06cbcedcffd8 MTHSPL
SPL_SET_ID e0e6412f-50b4-4fd4-9364-62818d121a07 MTHSPL
SRC Mol Cancer Ther 2004 Nov;3(11):1427-38 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUtBA SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T000867026 MSH
TERMUI T000874759 MSH
TERMUI T638362 MSH
TERMUI T639746 MSH
TERMUI T639747 MSH
TERMUI T639748 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (2005) MSH
TH NLM (2014) MSH
TH NLM (2015) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4980^Active/Master NDFRT
VANDF_RECORD 50.6^4994^Active/Master NDFRT
VUID 4034136 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C3853822

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