skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
sofosbuvir (CUI C2976303) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C2976303

NCI Thesaurus Code: C101263  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Nucleic Acid, Nucleoside, or Nucleotide

NCIt Definition: An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.

PDQ Definition: An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome. Check for active clinical trials using this agent.

MSH Definition: A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C.

Synonyms & Abbreviations: (see Synonym Details)
2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester
7977, PSI
GS 7977
GS-7977
GS7977
L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl Ester
nucleotide NS5B inhibitor GS-7977
PSI 7977
PSI-7977
PSI7977
S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)- (phenoxy)phosphorylamino)propanoate
Sofosbuvir (product)
Sofosbuvir (substance)
Sofosbuvir [Chemical/Ingredient]
Sofosbuvir

External Source Codes: 
NCI Thesaurus Code C101263 (see NCI Thesaurus info)
CAS Registry Number 1190307-88-0 (see NLM ChemIDplus info)
FDA UNII Code WJ6CA3ZU8B
PDQ Closed Trial Search ID 729636
PDQ Open Trial Search ID 729636 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 20845908 (see PubMed Primary Reference info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C22H29FN3O9P NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUrb1 SNOMEDCT_US
CTV3ID XUsRV SNOMEDCT_US
DATE_FIRST_PUBLISHED 2012-03-23 PDQ
DATE_LAST_MODIFIED 2012-08-16 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 20160101 MSH
EFFECTIVE_TIME 20150731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE WJ6CA3ZU8B DRUGBANK
FDA_UNII_CODE WJ6CA3ZU8B NDFRT
HN 2016 (2010) MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 20150701 MSH
MESH_DEFINITION A uridine monophosphate analog inhibitor of HEPATITIS C VIRUS (HCV) polymerase NS5B that is used as an ANTIVIRAL AGENT in the treatment of CHRONIC HEPATITIS C. NDFRT
MESH_DUI D000069474 NDFRT
MESH_NAME Sofosbuvir NDFRT
MESH_UI M0551450 NDFRT
MMR 20160531 MSH
MN D03.383.742.686.850.877.500 MSH
MN D13.695.740.850.877.500 MSH
MN D13.695.827.919.877.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C101263 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000189539 NDFRT
NUI N0000191981 NDFRT
ORIG_STY Drug/agent PDQ
PA D000998 MSH
PM 2016; SOFOSBUVIR was indexed under URIDINE MONOPHOSPHATE 2010-2015 MSH
RN 0 MSH
RN WJ6CA3ZU8B MSH
RXAUI 5933620 RXNORM
RXAUI 5933701 RXNORM
RXAUI 5940650 RXNORM
RXAUI 5948021 RXNORM
RXAUI 5948022 RXNORM
RXAUI 7714308 RXNORM
RXAUI 7715351 RXNORM
RXAUI 7715352 RXNORM
RXCUI 1484911 RXNORM
SPL_SET_ID 1a1c555d-2fdf-4150-8ace-dbc770c226bf MTHSPL
SPL_SET_ID 7f30631a-ee3b-4cfe-866b-964df3f0a44f MTHSPL
SPL_SET_ID 80beab2c-396e-4a37-a4dc-40fdb62859cf MTHSPL
SPL_SET_ID 996466df-f236-4804-b10f-838aa83231a1 MTHSPL
SPL_SET_ID b66d2de5-8550-4015-9c2c-d7a9150926b4 MTHSPL
SPL_SET_ID f4ec77e4-bae8-4db0-b3d5-bde09c5fa075 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUrb1 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUsRV SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T000880311 MSH
TERMUI T780291 MSH
TERMUI T780292 MSH
TERMUI T780293 MSH
TERMUI T780294 MSH
TERMUI T835904 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (2010) MSH
TH NLM (2013) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4899^Active/Master NDFRT
VANDF_RECORD 50.6^4867^Active/Master NDFRT
VUID 4032949 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C2976303

Mainbox Bottom