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Peripheral Arterial Diseases (CUI C1704436) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C1704436

NCI Thesaurus Code: C84496  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A disorder of the arteries supplying the upper and lower extremity and the visceral organs. This includes the mesenteric arteries, the renal arteries and the aorta and excludes cerebrovascular arterial disease. Patients experience cramping and pain usually in the calves and thighs while walking. The symptoms subside with rest.

MEDLINEPLUS Definition: 

Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is atherosclerosis. This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs. Plaque is a substance made up of fat and cholesterol. It causes the arteries to narrow or become blocked. This can reduce or stop blood flow, usually to the legs. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg.

The main risk factor for PAD is smoking. Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke.

Many people who have PAD don't have any symptoms. If you have symptoms, they may include

  • Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs.
  • Weak or absent pulses in the legs or feet
  • Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all
  • A pale or bluish color to the skin
  • A lower temperature in one leg than the other leg
  • Poor nail growth on the toes and decreased hair growth on the legs
  • Erectile dysfunction, especially among men who have diabetes

PAD can increase your risk of heart attack, stroke, and transient ischemic attack.

Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high cholesterol levels and high blood pressure.

NIH: National Heart, Lung, and Blood Institute

MSH Definition: Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less.

Synonyms & Abbreviations: (see Synonym Details)
Arterial Disease, Peripheral
Arterial Diseases, Peripheral
Artery Disease, Peripheral
Artery Diseases, Peripheral
Disease, Peripheral Arterial
Disease, Peripheral Artery
Diseases, Peripheral Arterial
Diseases, Peripheral Artery
PAD
Peripheral Arterial Disease [Disease/Finding]
Peripheral Arterial Diseases
Peripheral arterial disease
Peripheral Arterial Disorder
Peripheral Artery Diseases
Peripheral artery disease

External Source Codes: 
NCI Thesaurus Code C84496 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
AN coordinate IM with specific peripheral artery IM if pertinent MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
DATE_CREATED 02/17/2005 MEDLINEPLUS
DC 1 MSH
DX 20110101 MSH
HN 2011; for PERIPHERAL ARTERIAL DISEASES use PERIPHERAL VASCULAR DISEASES 2007-2010 MSH
MDA 20100625 MSH
MESH_DEFINITION Lack of perfusion in the EXTREMITIES resulting from atherosclerosis. It is characterized by INTERMITTENT CLAUDICATION, and an ANKLE BRACHIAL INDEX of 0.9 or less. NDFRT
MESH_DUI D058729 NDFRT
MESH_NAME Peripheral Arterial Disease NDFRT
MESH_UI M0490511 NDFRT
MN C14.907.137.126.307.500 MSH
MN C14.907.617.671 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/peripheralarterialdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Bosnian https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Bosnian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Simplified https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Chinese - Simplified MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Chinese - Traditional https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Chinese - Traditional MEDLINEPLUS
MP_OTHER_LANGUAGE_URL French https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#French MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hindi https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Hindi MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Japanese https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Japanese MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Korean https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Korean MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/peripheralarterialdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Ukrainian https://www.nlm.nih.gov/medlineplus/languages/peripheralarterialdisease.html#Ukrainian MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Heart, Lung, and Blood Institute http://www.nhlbi.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000182221 NDFRT
PM 2011; for PERIPHERAL ARTERIAL DISEASES see PERIPHERAL VASCULAR DISEASES 2007-2010 MSH
REF http://orcid.org/0000-0001-6908-9849 HPO
RXAUI 3606205 RXNORM
RXAUI 3606206 RXNORM
RXAUI 3606207 RXNORM
RXAUI 3606208 RXNORM
RXCUI 1085311 RXNORM
SID HP:0004973 HPO
SID HP:0005299 HPO
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T655545 MSH
TERMUI T766935 MSH
TERMUI T766936 MSH
TH NLM (2007) MSH
TH NLM (2011) MSH
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C1704436

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