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Armodafinil (CUI C1701455) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C1701455

NCI Thesaurus Code: C65241  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: The R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. Although the exact mechanism of action has yet to be fully elucidated, armodafinil appears to inhibit the reuptake of dopamine by binding to the dopamine-reuptake pump, which leads to an increase in extracellular dopamine levels in some brain regions. This agent does not bind to or inhibit several receptors and enzymes that may be involved in sleep/wake regulation and is not a direct- or indirect-acting dopamine receptor agonist. Armodafinil has a longer half-life than modafinil.

PDQ Definition: The R-enantiomer of the racemic synthetic agent modafinil with central nervous system (CNS) stimulant and wakefulness-promoting activities. Although the exact mechanism of action has yet to be fully elucidated, armodafinil appears to inhibit the reuptake of dopamine by binding to the dopamine-reuptake pump, which leads to an increase in extracellular dopamine levels in some brain regions. This agent does not bind to or inhibit several receptors and enzymes that may be involved in sleep/wake regulation and is not a direct- or indirect-acting dopamine receptor agonist. Armodafinil has a longer half-life than modafinil. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug that is used to treat certain sleep disorders, such as narcolepsy. It makes patients feel more alert and awake. It is also being studied in the treatment of insomnia and fatigue in patients treated for cancer. Armodafinil acts in a part of the brain that controls sleep and wakefulness. It is a type of wakefulness-promoting agent.

Synonyms & Abbreviations: (see Synonym Details)
(-)-2-((R)-(Diphenylmethyl)sulfinyl)acetamide
(-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide
2-((R)-(diphenylmethyl)sulfinyl)acetamide
Armodafinil (substance)
Armodafinil
Nuvigil
Product containing armodafinil (medicinal product)
Product containing armodafinil
R-modafinil

External Source Codes: 
NCI Thesaurus Code C65241 (see NCI Thesaurus info)
CAS Registry Number 112111-43-0 (see NLM ChemIDplus info)
FDA UNII Code V63XWA605I
PDQ Closed Trial Search ID 617902
PDQ Open Trial Search ID 617902 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Excessive sleepiness NCI
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C15H15NO2S NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUfyy SNOMEDCT_US
CTV3ID XUgBC SNOMEDCT_US
DATE_FIRST_PUBLISHED 2008-10-17 PDQ
DATE_LAST_MODIFIED 2010-02-18 PDQ
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20080131 SNOMEDCT_US
FDA_UNII_CODE V63XWA605I DRUGBANK
FDA_UNII_CODE V63XWA605I NDFRT
FR 89 MSH
HM D001559 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 20131024 MSH
MMR 20141022 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C65241 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NUI N0000176106 NDFRT
ORIG_STY Drug/agent PDQ
PA D064690 MSH
RN V63XWA605I MSH
RXAUI 2715368 RXNORM
RXAUI 2720756 RXNORM
RXAUI 2861662 RXNORM
RXAUI 2861693 RXNORM
RXAUI 3102526 RXNORM
RXAUI 3102527 RXNORM
RXAUI 3612814 RXNORM
RXCUI 641465 RXNORM
RXCUI 710995 RXNORM
RXN_BN_CARDINALITY single RXNORM
SC 1 MSH
SOS the R-enantiomer of modafinil MSH
SPL_SET_ID 0310a062-51fd-4e74-8a5f-7f21a16f52c9 MTHSPL
SPL_SET_ID 10f918f7-4782-470e-a50e-35c7c66bfd79 MTHSPL
SPL_SET_ID 253f7061-449a-4824-8290-15827b14fe76 MTHSPL
SPL_SET_ID 2c824d4c-2309-4e2a-bc74-aa8d80a5c454 MTHSPL
SPL_SET_ID 2fb5e68a-c543-4dd7-8d57-798548c3963e MTHSPL
SPL_SET_ID 795a7ba3-c60b-4637-aa99-06c1e10af8a7 MTHSPL
SPL_SET_ID a2b3b762-7984-409c-82e4-8d216055df72 MTHSPL
SPL_SET_ID cfa0ae8e-1c94-42e8-a19c-7278cc5cf634 MTHSPL
SPL_SET_ID d878aed0-ddbf-8fa1-abf7-d3e480260845 MTHSPL
SPL_SET_ID de0799f7-7644-4057-a7da-75436f978c61 MTHSPL
SPL_SET_ID e7bfb636-4b0a-440c-a4d3-d26393a14ac5 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUfyy SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUgBC SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T672007 MSH
TERMUI T687432 MSH
TERMUI T840252 MSH
TH INN (19XX) MSH
TH NLM (2006) MSH
TH NLM (2014) MSH
TH USAN (2006) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4467^Active/Master NDFRT
VANDF_RECORD 50.6^4267^Active/Master NDFRT
VUID 4026237 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C1701455

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