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Sjogren's Syndrome (CUI C1527336) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C1527336

NCI Thesaurus Code: C26883  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus.

GARD Definition: Sjögren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. The hallmark symptoms of the disorder are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. Treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs.
- this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. It can also lead to dryness in other places that need moisture, such as your nose, throat and skin. Most people who get Sjogren's syndrome are older than 40. Nine of 10 are women. Sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis.

Sjogren's syndrome is an autoimmune disease. If you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. In Sjogren's syndrome, your immune system attacks the glands that make tears and saliva. It may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. The main symptoms are:

Treatment focuses on relieving symptoms.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

NCI-GLOSS Definition: An autoimmune disease that affects the tear glands and salivary glands, and may affect glands in the stomach, pancreas, and intestines. The disease causes dry eyes and mouth, and may cause dryness in the nose, throat, air passages, skin, and vagina. It may also cause inflammation in the joints, muscles, and skin; pneumonia; tingling in the fingers and toes; and fatigue. It often occurs with rheumatoid arthritis or other connective tissue diseases.

NICHD Definition: Autoimmune epithelial inflammation often affecting the salivary and lacrimal glands (causing dry mouth and dry eyes) with potential extraglandular manifestations. In children, it most commonly presents with recurrent parotitis. It may occur alone (primary) or in association with another autoimmune disease (secondary).

CSP Definition: symptom complex of unknown etiology, usually occurring in middle-aged or older women, marked by the triad of keratoconjunctivitis sicca with or without lacrimal gland enlargement, xerostomia with or without salivary gland enlargement, and the presence of a connective tissue disease, usually rheumatoid arthritis but sometimes systemic lupus erythematosus, scleroderma, or polymyositis; an abnormal immune response has been implicated.

MSH Definition: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.

Synonyms & Abbreviations: (see Synonym Details)
Gougerot-Mulock-Houwer syndrome
Sicca syndrome [Sjögren]
SJOEGREN SYNDROME
Sjoegren's syndrome
SJOGREN SYNDROME
Sjogren's disease
Sjogren's Syndrome [Disease/Finding]
Sjogren's Syndrome
Sjogren's
SJOGRENS SYNDROME
Sjögren Syndrome
Sjögren's disease
Sjögren's syndrome (disorder)
Sjögren's syndrome
SYNDROME SJOGREN'S
Syndrome, Sjogren's

External Source Codes: 
NCI Thesaurus Code C26883 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN a form of rheum arthritis; do not confuse with SJOGREN-LARSSON SYNDROME, a form of ichthyosis; in titles & translations, use diacrit: Sjogren MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source FDA NCI
Contributing_Source NICHD NCI
CTV3ID Xa0hF SNOMEDCT_US
DATE_CREATED 11/10/1999 MEDLINEPLUS
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0729-8405 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FDA_Table Patient Code (Appendix B) NCI
FX D007638 MSH
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
INCLUSION_TERM Sjögren's syndrome with: keratoconjunctivitis ICD10
INCLUSION_TERM Sjögren's syndrome with: lung involvement ICD10
INCLUSION_TERM Sjögren's syndrome with: myopathy ICD10
INCLUSION_TERM Sjögren's syndrome with: renal tubulo-interstitial disorders ICD10
IS_RARE false GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Modified GARD
LAST_REVIEW_DATE 2013-10-03T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis. NDFRT
MESH_DUI D012859 NDFRT
MESH_NAME Sjogren's Syndrome NDFRT
MESH_UI M0019911 NDFRT
MIMTYPE 5 OMIM
MIMTYPEMEANING Mendelian phenotype or locus, molecular basis unknown. OMIM
MIMTYPEVALUE perc OMIM
MMR 20120703 MSH
MN C05.550.114.154.774 MSH
MN C05.799.114.774 MSH
MN C07.465.815.929.669 MSH
MN C11.496.260.719 MSH
MN C17.300.775.099.774 MSH
MN C20.111.199.774 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/sjogrenssyndrome.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/sjogrenssyndrome.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Dental and Craniofacial Research http://www.nidcr.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Sjogren Syndrome NCI
NUI N0000002758 NDFRT
ORDER_NO 17988 ICD10CM
PRIMARY_PATH 10040767$10074472$10010761$10028395$Sjogren's syndrome$Connective tissue disorders NEC$Connective tissue disorders (excl congenital)$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/10252/sjogren-syndrome/resources/1 GARD
RXAUI 3238543 RXNORM
RXAUI 3238544 RXNORM
RXAUI 5039959 RXNORM
RXCUI 1023647 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 12.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 12.1 MDR
SMQ_TERM_LMVERSION 13.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 83901003 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M35.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M35.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M35.00 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M35.00 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Xa0hF SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T037915 MSH
TERMUI T812571 MSH
TH NLM (1966) MSH
TH OMIM (2013) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C1527336

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