|Terms & Properties|
Concept Unique Identifier (CUI): C1527336
NCI Thesaurus Code: C26883 (see NCI Thesaurus info)
Semantic Type: Disease or Syndrome
NCIt Definition: An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus.
GARD Definition: Sjögren syndrome is an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis. The hallmark symptoms of the disorder are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness, and may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain. Treatment is symptomatic and supportive and may include moisture replacement therapies, nonsteroidal anti-inflammatory drugs and, in severe cases, corticosteroids or immunosuppressive drugs.
- this information is from GARD/ORDR/NCATS.
Sjogren's syndrome is a disease that causes dryness in your mouth and eyes. It can also lead to dryness in other places that need moisture, such as your nose, throat and skin. Most people who get Sjogren's syndrome are older than 40. Nine of 10 are women. Sjogren's syndrome is sometimes linked to rheumatic problems such as rheumatoid arthritis.
Sjogren's syndrome is an autoimmune disease. If you have an autoimmune disease, your immune system, which is supposed to fight disease, mistakenly attacks parts of your own body. In Sjogren's syndrome, your immune system attacks the glands that make tears and saliva. It may also affect your joints, lungs, kidneys, blood vessels, digestive organs and nerves. The main symptoms are:
Treatment focuses on relieving symptoms.
NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases
NCI-GLOSS Definition: An autoimmune disease that affects the tear glands and salivary glands, and may affect glands in the stomach, pancreas, and intestines. The disease causes dry eyes and mouth, and may cause dryness in the nose, throat, air passages, skin, and vagina. It may also cause inflammation in the joints, muscles, and skin; pneumonia; tingling in the fingers and toes; and fatigue. It often occurs with rheumatoid arthritis or other connective tissue diseases.
NICHD Definition: Autoimmune epithelial inflammation often affecting the salivary and lacrimal glands (causing dry mouth and dry eyes) with potential extraglandular manifestations. In children, it most commonly presents with recurrent parotitis. It may occur alone (primary) or in association with another autoimmune disease (secondary).
CSP Definition: symptom complex of unknown etiology, usually occurring in middle-aged or older women, marked by the triad of keratoconjunctivitis sicca with or without lacrimal gland enlargement, xerostomia with or without salivary gland enlargement, and the presence of a connective tissue disease, usually rheumatoid arthritis but sometimes systemic lupus erythematosus, scleroderma, or polymyositis; an abnormal immune response has been implicated.
MSH Definition: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
Synonyms & Abbreviations: (see Synonym Details)
|Sicca syndrome [Sjögren]|
|Sjogren's Syndrome [Disease/Finding]|
|Sjögren's syndrome (disorder)|
External Source Codes:
|NCI Thesaurus Code||C26883 (see NCI Thesaurus info)|
|AN||a form of rheum arthritis; do not confuse with SJOGREN-LARSSON SYNDROME, a form of ichthyosis; in titles & translations, use diacrit: Sjogren||MSH|
|AQL||BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI||MSH|
|FDA_Table||Patient Code (Appendix B)||NCI|
|INCLUSION_TERM||Sjögren's syndrome with: keratoconjunctivitis||ICD10|
|INCLUSION_TERM||Sjögren's syndrome with: lung involvement||ICD10|
|INCLUSION_TERM||Sjögren's syndrome with: myopathy||ICD10|
|INCLUSION_TERM||Sjögren's syndrome with: renal tubulo-interstitial disorders||ICD10|
|MESH_DEFINITION||Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.||NDFRT|
|MIMTYPEMEANING||Mendelian phenotype or locus, molecular basis unknown.||OMIM|
|MP_PRIMARY_INSTITUTE_URL||National Institute of Dental and Craniofacial Research http://www.nidcr.nih.gov/||MEDLINEPLUS|
|PRIMARY_PATH||10040767$10074472$10010761$10028395$Sjogren's syndrome$Connective tissue disorders NEC$Connective tissue disorders (excl congenital)$Musculoskeletal and connective tissue disorders||MDR|
|SUBSET_MEMBER||6011000124106~MAPADVICE~ALWAYS M35.00 | DESCENDANTS NOT EXHAUSTIVELY MAPPED||SNOMEDCT_US|
Additional Concept Data: (none)