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vardenafil (CUI C0971579) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0971579

NCI Thesaurus Code: C66650  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A benzenesulfonamide derivative and phosphodiesterase type 5 (PDE5) inhibitor with vasodilatory activity. Vardenafil selectively inhibits PDE5, thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. The inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, prolonging penile erection.

Synonyms & Abbreviations: (see Synonym Details)
1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine
2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-F][1,2,4]triazin-4(1H)-one
Product containing vardenafil (medicinal product)
Product containing vardenafil
Vardenafil (substance)
Vardenafilum
Vardenafil
Vardénafil

External Source Codes: 
NCI Thesaurus Code C66650 (see NCI Thesaurus info)
CAS Registry Number 224785-90-4 (see NLM ChemIDplus info)
FDA UNII Code UCE6F4125H

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:46295 NCI
Chemical_Formula C23H32N6O4S NCI
Contributing_Source FDA NCI
CTV3ID gh8.. SNOMEDCT_US
CTV3ID XUaAJ SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20040131 SNOMEDCT_US
FDA_UNII_CODE UCE6F4125H DRUGBANK
FDA_UNII_CODE UCE6F4125H NDFRT
LEVEL Ingredient NDFRT
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NUI N0000148820 NDFRT
RN UCE6F4125H MSH
RXAUI 1395204 RXNORM
RXAUI 1395209 RXNORM
RXAUI 3253365 RXNORM
RXAUI 3253366 RXNORM
RXAUI 6396033 RXNORM
RXCUI 306674 RXNORM
SID APRD00699 DRUGBANK
SPL_SET_ID 0e5139d8-bf61-4f21-a36b-81b96b9b07d1 MTHSPL
SPL_SET_ID 1f71920c-0e54-46e8-82c8-3ea5d212d469 MTHSPL
SPL_SET_ID 34c30372-08b0-4060-8aba-779b5bc1e5dd MTHSPL
SPL_SET_ID 3cded133-c2a9-41fa-94e2-6f468fa8b9a1 MTHSPL
SPL_SET_ID 4e66ad5c-572c-4819-8b6e-6930c33cc210 MTHSPL
SPL_SET_ID 517fbb02-8793-4647-83c7-25a91be49622 MTHSPL
SPL_SET_ID 8f935afa-f845-46cd-b61a-db7a48e559c0 MTHSPL
SPL_SET_ID a01def95-c0ef-43b9-bd9e-5565b2385ad3 MTHSPL
SPL_SET_ID b3bbc16e-8305-469a-9dc3-8e698339a98b MTHSPL
SPL_SET_ID be38b325-3a6f-4569-9ae0-a03feff8535d MTHSPL
SPL_SET_ID f18a82f7-ce44-4f9c-ae69-d3ad1d375564 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~gh8.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUaAJ SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T000878258 MSH
TERMUI T447214 MSH
TH FDA SRS (2013) MSH
TH INN (19XX) MSH
TH NLM (2001) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4080^Active/Master NDFRT
VANDF_RECORD 50.6^3898^Active/Master NDFRT
VUID 4021404 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0971579

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