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rosuvastatin (CUI C0965129) Suggest changes to this concept
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Terms & Properties Synonym Details Relationships Sources View All  
Terms & Properties

Concept Unique Identifier (CUI): C0965129

NCI Thesaurus Code: C66523  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.

Synonyms & Abbreviations: (see Synonym Details)
(3R,5S,6e)-7-(4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(ethyl(methylsulfonyl)amino)-5-pyrimidinyl)-3,5-dihydroxy-6-heptenoic acid
(3R,5S,6e)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
Rosuvastatin
Rosuvastatin (product)
Rosuvastatin (substance)

External Source Codes: 
NCI Thesaurus Code C66523 (see NCI Thesaurus info)
CAS Registry Number 287714-41-4 (see NLM ChemIDplus info)
FDA UNII Code 413KH5ZJ73
PDQ Closed Trial Search ID 654583
PDQ Open Trial Search ID 654583 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:38545 NCI
Chemical_Formula C22H28FN3O6S NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID bxk.. SNOMEDCT_US
CTV3ID XUmqo SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20040131 SNOMEDCT_US
EFFECTIVE_TIME 20140731 SNOMEDCT_US
FDA_UNII_CODE 413KH5ZJ73 DRUGBANK
FDA_UNII_CODE 413KH5ZJ73 NDFRT
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NUI N0000148821 NDFRT
RN 413KH5ZJ73 MSH
RXAUI 1386783 RXNORM
RXAUI 1386788 RXNORM
RXAUI 3228742 RXNORM
RXAUI 3228743 RXNORM
RXAUI 6395870 RXNORM
RXAUI 8238205 RXNORM
RXCUI 301542 RXNORM
SID APRD00546 DRUGBANK
SNOMEDID C-8082B SNOMEDCT_US
SNOMEDID R-FB637 SNOMEDCT_US
SPL_SET_ID 11e75623-88f2-4456-84cd-4a10067d7398 MTHSPL
SPL_SET_ID 134c5455-5171-66f3-e0c4-c475978ffb22 MTHSPL
SPL_SET_ID 1a69848d-95d7-41e8-a3a0-aa5367d4f03b MTHSPL
SPL_SET_ID 1fd0ba23-962e-427f-8b9d-2cf8f64d0f95 MTHSPL
SPL_SET_ID 20c6225c-9afe-387b-e054-00144ff88e88 MTHSPL
SPL_SET_ID 2c1a3c18-fa77-401b-8784-8e18b0d862f1 MTHSPL
SPL_SET_ID 392657a9-955c-42c2-814c-1890ece45afa MTHSPL
SPL_SET_ID 3bc20553-4f42-4a1d-8075-69d885446212 MTHSPL
SPL_SET_ID 3ec57aa3-4399-46c9-9292-567d2a09df4f MTHSPL
SPL_SET_ID 47924917-bbd5-45de-96cb-c7ff9754da97 MTHSPL
SPL_SET_ID 480fbe20-6b58-4504-99d0-6e0cf2170e5a MTHSPL
SPL_SET_ID 4979a072-b63a-9d03-f606-50040b0c2e58 MTHSPL
SPL_SET_ID 4f2f91bb-f119-4e29-8499-f36f436707b3 MTHSPL
SPL_SET_ID 5c992d3d-d754-48b6-a267-1451208352ed MTHSPL
SPL_SET_ID 5dfefed9-5b84-41f7-a8a4-e118f9518d3e MTHSPL
SPL_SET_ID 61aad0b2-0ea9-cddb-e58e-e9bc83bf0f94 MTHSPL
SPL_SET_ID 664870d8-64cf-49b0-bd7a-15a16d95e4c8 MTHSPL
SPL_SET_ID 778b1225-3c5d-4683-9888-8b3306a6e49d MTHSPL
SPL_SET_ID 861f5730-9b6a-4d8a-9258-dee552dc3fc0 MTHSPL
SPL_SET_ID 9735c934-3e2c-4294-9127-fe9904c003c7 MTHSPL
SPL_SET_ID a16450f1-77ea-4017-b4ed-a3c5401f9dbf MTHSPL
SPL_SET_ID a9ed7843-2a77-4f60-a703-b36585f5fd51 MTHSPL
SPL_SET_ID ab9f816e-df48-4d90-b8ca-98477659531a MTHSPL
SPL_SET_ID bb0f3b5e-4bc6-41c9-66b9-6257e2513512 MTHSPL
SPL_SET_ID c5b121bc-cb72-4411-856d-aa71b40bb660 MTHSPL
SPL_SET_ID c5f46f1b-3594-4ff4-b208-a7b9f830e87e MTHSPL
SPL_SET_ID dde48e6f-1dd0-41f1-a1a5-01aa9a7459ba MTHSPL
SPL_SET_ID e498b80d-7177-4f9d-8471-2e8f913196af MTHSPL
SPL_SET_ID e51b64ad-b33b-4015-9388-ce95f7c71f5d MTHSPL
SPL_SET_ID ee975379-9578-4f94-8783-8bb9684dced0 MTHSPL
SPL_SET_ID ef243da2-d388-40e4-a1cb-a5e0688efc49 MTHSPL
SPL_SET_ID f510884e-fb40-44b5-9eb4-9fc898c5e626 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~bxk.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUmqo SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-8082B SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~R-FB637 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T000877042 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (2001) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4081^Active/Master NDFRT
VANDF_RECORD 50.6^3899^Active/Master NDFRT
VUID 4021405 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0965129

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