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Rosuvastatin (CUI C0965129) Suggest changes to this concept
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Terms & Properties Synonym Details Relationships Sources View All  
Terms & Properties

Concept Unique Identifier (CUI): C0965129

NCI Thesaurus Code: C66523  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A statin with antilipidemic and potential antineoplastic activities. Rosuvastatin selectively and competitively binds to and inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. This leads to a decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. In addition, rosuvastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cell types; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.

Synonyms & Abbreviations: (see Synonym Details)
ROSUVASTATIN
Rosuvastatin (product)
Rosuvastatin (substance)

External Source Codes: 
NCI Thesaurus Code C66523 (see NCI Thesaurus info)
CAS Registry Number 287714-41-4 (see NLM ChemIDplus info)
FDA UNII Code 413KH5ZJ73
PDQ Closed Trial Search ID 654583
PDQ Open Trial Search ID 654583 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHEBI_ID CHEBI:38545 NCI
Chemical_Formula C22H28FN3O6S NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID bxk.. SNOMEDCT_US
CTV3ID XUmqo SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20040131 SNOMEDCT_US
EFFECTIVE_TIME 20140731 SNOMEDCT_US
FDA_UNII_CODE 413KH5ZJ73 NDFRT
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
NDFRT_KIND DRUG_KIND NDFRT
NUI N0000148821 NDFRT
RN 413KH5ZJ73 MSH
RXAUI 1386783 RXNORM
RXAUI 1386788 RXNORM
RXAUI 3228742 RXNORM
RXAUI 3228743 RXNORM
RXAUI 6395870 RXNORM
RXCUI 301542 RXNORM
SNOMEDID C-8082B SNOMEDCT_US
SNOMEDID R-FB637 SNOMEDCT_US
SPL_SET_ID 11e75623-88f2-4456-84cd-4a10067d7398 MTHSPL
SPL_SET_ID 1a69848d-95d7-41e8-a3a0-aa5367d4f03b MTHSPL
SPL_SET_ID 1fd0ba23-962e-427f-8b9d-2cf8f64d0f95 MTHSPL
SPL_SET_ID 20c6225c-9afe-387b-e054-00144ff88e88 MTHSPL
SPL_SET_ID 2c1a3c18-fa77-401b-8784-8e18b0d862f1 MTHSPL
SPL_SET_ID 3ec57aa3-4399-46c9-9292-567d2a09df4f MTHSPL
SPL_SET_ID 3ff3ed01-e4ed-437d-90b0-cae7ba23c342 MTHSPL
SPL_SET_ID 4f2f91bb-f119-4e29-8499-f36f436707b3 MTHSPL
SPL_SET_ID 5dfefed9-5b84-41f7-a8a4-e118f9518d3e MTHSPL
SPL_SET_ID 778b1225-3c5d-4683-9888-8b3306a6e49d MTHSPL
SPL_SET_ID a16450f1-77ea-4017-b4ed-a3c5401f9dbf MTHSPL
SPL_SET_ID ab9f816e-df48-4d90-b8ca-98477659531a MTHSPL
SPL_SET_ID bb0f3b5e-4bc6-41c9-66b9-6257e2513512 MTHSPL
SPL_SET_ID c5b121bc-cb72-4411-856d-aa71b40bb660 MTHSPL
SPL_SET_ID c5f46f1b-3594-4ff4-b208-a7b9f830e87e MTHSPL
SPL_SET_ID e498b80d-7177-4f9d-8471-2e8f913196af MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~bxk.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUmqo SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-8082B SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~R-FB637 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T000877042 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (2001) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4081^Active/Master NDFRT
VANDF_RECORD 50.6^3899^Active/Master NDFRT
VUID 4021405 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0965129

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