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Lewy Body Disease (CUI C0752347) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0752347

NCI Thesaurus Code: C84826  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A progressive form of dementia characterized by the presence of protein deposits called Lewy bodies in the midbrain and cerebral cortex, and loss of cholinergic and dopaminergic neurons. The signs and symptoms overlap with Alzheimer and Parkinson disease.

RADLEX Definition: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, muscle rigidity, and other extrapyramidal signs. delusions and visual hallucinations are relatively frequent in this condition. Histologic examination reveals lewy bodies in the cerebral cortex and brain stem. senile plaques and other pathologic features characteristic of alzheimer disease may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124) [MeSH]

GARD Definition: Lewy bodies dementia is one of the most common types of dementia. The central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. Although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called Lewy bodies, inside the brain. This condition usually occurs sporadically, in people with no known family history of the disease. However, rare familial cases have been reported. - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental functions severe enough to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build up in areas of the brain. The disease may cause a wide range of symptoms, including

  • Changes in alertness and attention
  • Hallucinations
  • Problems with movement and posture
  • Muscle stiffness
  • Confusion
  • Loss of memory

Lewy body disease can be hard to diagnose, because Parkinson's disease and Alzheimer's disease cause similar symptoms. Scientists think that Lewy body disease might be related to these diseases, or that they sometimes happen together.

Lewy body disease usually begins between the ages of 50 and 85. The disease gets worse over time. There is no cure. Treatment focuses on drugs to help symptoms.

NIH: National Institute of Neurological Disorders and Stroke

MSH Definition: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)

Synonyms & Abbreviations: (see Synonym Details)
CLBD - Cortical Lewy body disease
Cortical Lewy Body Disease
CORTICAL LEWY BODY DIS
Dementia of the Lewy body type
Dementia w Lewy bodies
Dementia with Lewy bodies
Dementia, Lewy Body
Diffuse Lewy body disease (disorder)
Diffuse Lewy body disease
DIFFUSE LEWY BODY DIS
DLBD - Diffuse Lewy body disease
DLB
LBD - Lewy body disease
Lewy body dementia
LEWY BODY DIS CORTICAL
LEWY BODY DIS DIFFUSE
Lewy Body Disease [Disease/Finding]
Lewy Body Disease, Cortical
Lewy Body Disease, Diffuse
Lewy body disease
LEWY BODY DIS
Lewy Body Type Senile Dementia
Lewy body variant of Alzheimer's disease
Lewy-Körperchen-Demenz
SDLT - Senile dementia of the Lewy body type
Senile dementia of the Lewy body type (disorder)
Senile dementia of the Lewy body type

External Source Codes: 
NCI Thesaurus Code C84826 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN LEWY BODY PARKINSON DISEASE see PARKINSON DISEASE is also available MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CTV3ID X003A SNOMEDCT_US
CTV3ID XaE74 SNOMEDCT_US
DATE_CREATED 02/01/2005 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DISEASE_IDENTIFIER_ID 11422 GARD
DISEASE_IDENTIFIER_ID 11423 GARD
DISEASE_IDENTIFIER_ID 11424 GARD
DX 20000101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D016631 MSH
GENELOCUS ,1,q,2,1, OMIM
GENESYMBOL GBA OMIM
HAS_GARD_PAGE true GARD
HN 2000; use PARKINSON DISEASE 1992-1999; for DIFFUSE LEWY BODY DISEASE & LEWY BODY DISEASE, DIFFUSE use PARKINSON DISEASE 1992-1999 MSH
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19991108 MSH
MESH_DEFINITION A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124) NDFRT
MESH_DUI D020961 NDFRT
MESH_NAME Lewy Body Disease NDFRT
MESH_UI M0015964 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20150623 MSH
MN C10.228.140.079.862.400 MSH
MN C10.228.140.380.422 MSH
MN C10.228.662.600.200 MSH
MN C10.574.531 MSH
MN F03.615.400.512 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/lewybodydisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/lewybodydisease.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000004234 NDFRT
ORDER_NO 05885 ICD10CM
PM 2000; see PARKINSON DISEASE 1992-1999; for DIFFUSE LEWY BODY DISEASE & LEWY BODY DISEASE, DIFFUSE see PARKINSON DISEASE 1992-1999 MSH
PRIMARY_PATH 10067889$10012268$10057167$10029205$Dementia with Lewy bodies$Dementia (excl Alzheimer's type)$Mental impairment disorders$Nervous system disorders MDR
PRIMARY_SOC 10029205 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/3243/lewy-body-dementia/resources/1 GARD
RXAUI 3135878 RXNORM
RXAUI 3145417 RXNORM
RXAUI 3146829 RXNORM
RXAUI 3189399 RXNORM
RXAUI 3189400 RXNORM
RXAUI 3189401 RXNORM
RXAUI 3189402 RXNORM
RXAUI 3189405 RXNORM
RXAUI 5039584 RXNORM
RXCUI 1022348 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 11.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.0 MDR
SMQ_TERM_LMVERSION 13.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_STATUS I MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 312991009 NDFRT
SNOMED_CID 80098002 NDFRT
SNOMEDID DA-21036 SNOMEDCT_US
SNOMEDID DA-21038 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS F02.8 | THIS CODE MAY BE USED IN THE PRIMARY POSITION WHEN THE MANIFESTATION IS THE PRIMARY FOCUS OF CARE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G31.8 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~F02.8 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G31.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS F02.80 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G31.83 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF LEWY BODY DEMENTIA WITH BEHAVIORAL DISTURBANCE CHOOSE F02.81 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 135811000119107 | Lewy body dementia with behavioral disturbance (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F02.80 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F02.81 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G31.83 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X003A SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XaE74 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-21036 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-21038 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T030421 MSH
TERMUI T030422 MSH
TERMUI T030423 MSH
TERMUI T364488 MSH
TERMUI T364489 MSH
TERMUI T364490 MSH
TERMUI T364497 MSH
TERMUI T812501 MSH
TH NLM (1992) MSH
TH NLM (2000) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0752347

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