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linezolid (CUI C0663241) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0663241

NCI Thesaurus Code: C29158  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: A synthetic oxazolidinone derivative, Linezolid selectively inhibits an early step in bacterial protein synthesis and affects blood pressure through monoamine oxidase inhibition. It is effective against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus strains, coagulase-negative Staphylococci, vancomycin-resistant Enterococci, and penicillin-resistant Streptococcus pneumoniae strains. (NCI04)

PDQ Definition: A synthetic oxazolidinone derivative, linezolid selectively inhibits an early step in bacterial protein synthesis and affects blood pressure through monoamine oxidase inhibition. It is effective against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus strains, coagulase-negative Staphylococci, vancomycin-resistant Enterococci, and penicillin-resistant Streptococcus pneumoniae strains. Check for active clinical trials using this agent. (NCI Thesaurus)

MSH Definition: An oxazolidinone and acetamide derived ANTI-BACTERIAL AGENT and PROTEIN SYNTHESIS INHIBITOR that is used in the treatment of GRAM-POSITIVE BACTERIAL INFECTIONS of the skin and respiratory tract.

Synonyms & Abbreviations: (see Synonym Details)
165800-03-3
Linezolid (substance)
Linezolid [Chemical/Ingredient]
Linezolide
Linezolidum
Linezolid
N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide
N-((3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide
Product containing linezolid (medicinal product)
Product containing linezolid
Zyvox

External Source Codes: 
NCI Thesaurus Code C29158 (see NCI Thesaurus info)
CAS Registry Number 165800-03-3 (see NLM ChemIDplus info)
FDA UNII Code ISQ9I6J12J
PDQ Closed Trial Search ID 735710
PDQ Open Trial Search ID 735710 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:63607 NCI
Chemical_Formula C16H20FN3O4 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID ebB.. SNOMEDCT_US
CTV3ID XUWqB SNOMEDCT_US
DATE_FIRST_PUBLISHED 2012-06-19 PDQ
DATE_LAST_MODIFIED 2012-06-20 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 20160101 MSH
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE ISQ9I6J12J DRUGBANK
FDA_UNII_CODE ISQ9I6J12J NDFRT
HN 2016 (1996) MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 20150701 MSH
MESH_DEFINITION An oxazolidinone and acetamide derived ANTI-BACTERIAL AGENT and PROTEIN SYNTHESIS INHIBITOR that is used in the treatment of GRAM-POSITIVE BACTERIAL INFECTIONS of the skin and respiratory tract. NDFRT
MESH_DUI D000069349 NDFRT
MESH_NAME Linezolid NDFRT
MESH_UI M0257529 NDFRT
MMR 20160531 MSH
MN D02.065.064.463 MSH
MN D02.241.081.018.110.525 MSH
MN D03.383.129.462.600.550 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C29158 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006027 NDFRT
NUI N0000148664 NDFRT
ORIG_STY Drug/agent PDQ
PA D000900 MSH
PA D011500 MSH
PM 2016; LINEZOLID was indexed under ACETAMIDES and OXAZOLIDINONES 2000-2015; and under OXAZOLES 1996-2000 MSH
RN 0 MSH
RN ISQ9I6J12J MSH
RR 165800-03-3 MSH
RXAUI 1078127 RXNORM
RXAUI 1313007 RXNORM
RXAUI 2072065 RXNORM
RXAUI 2599685 RXNORM
RXAUI 3186988 RXNORM
RXAUI 3186989 RXNORM
RXAUI 3201340 RXNORM
RXAUI 5084335 RXNORM
RXAUI 7715028 RXNORM
RXAUI 7715029 RXNORM
RXAUI 7715030 RXNORM
RXAUI 8219587 RXNORM
RXCUI 190376 RXNORM
RXCUI 261710 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD01073 DRUGBANK
SID DB08769 DRUGBANK
SPL_SET_ID 122faa9e-c71a-4597-9552-5fb330b7d8b9 MTHSPL
SPL_SET_ID 14fde65e-b510-443c-bc67-08c599d02499 MTHSPL
SPL_SET_ID 16007ca5-7956-4414-af38-406a6623400e MTHSPL
SPL_SET_ID 2a02e028-263f-4673-ae85-19b784bd118c MTHSPL
SPL_SET_ID 2b5fe133-8100-4129-e054-00144ff88e88 MTHSPL
SPL_SET_ID 374af2a7-d994-40bd-a86a-cd9038d0b72c MTHSPL
SPL_SET_ID 3e5e9975-6f36-42e4-ab46-0e75dda83592 MTHSPL
SPL_SET_ID 50630775-7f76-413e-9278-ba298dd7f187 MTHSPL
SPL_SET_ID 545fde66-8402-41d4-8369-cae351c72296 MTHSPL
SPL_SET_ID 5ec10db9-6026-41fa-8abf-c86449392033 MTHSPL
SPL_SET_ID 6e70e63b-bfd5-478d-a8ee-8ba22c9efabd MTHSPL
SPL_SET_ID 7402aa01-50de-46c8-a341-d30da5b32b1c MTHSPL
SPL_SET_ID 7d39e73e-5088-4e92-8dad-72db613d478b MTHSPL
SPL_SET_ID 83a84897-ccca-42a1-ab1a-bbf1d43a982b MTHSPL
SPL_SET_ID 90bec4b1-d5c3-4880-8027-788b72d8e1fc MTHSPL
SPL_SET_ID a287cdf4-47a8-459f-8890-86181af5e836 MTHSPL
SPL_SET_ID b239458e-9a3e-49ac-9ac7-a4badc53dff6 MTHSPL
SPL_SET_ID b65ee68a-c50d-4d5e-955b-dde0214e861b MTHSPL
SPL_SET_ID b66216dd-e36d-c714-6a4f-3547fc676e87 MTHSPL
SPL_SET_ID b721756c-3b5e-456d-a2f6-0d8a56cc7f35 MTHSPL
SPL_SET_ID bef116a8-427d-4855-86de-0017e01430b0 MTHSPL
SPL_SET_ID c157eaea-ffe7-422c-a1ee-e696e3c13dd5 MTHSPL
SPL_SET_ID c401f1a8-cc37-461b-bfef-f2e156629bf8 MTHSPL
SPL_SET_ID ca930576-62ab-4af5-ac3e-27ca376baca6 MTHSPL
SPL_SET_ID cc3e3ea4-50aa-49ee-a8bc-fb48bfc8e014 MTHSPL
SPL_SET_ID d76293c8-2642-4bfc-97bf-59e37251723d MTHSPL
SPL_SET_ID dd26b439-35c6-4c6b-ba38-c1f4d2bf098a MTHSPL
SPL_SET_ID deb8287e-e06e-4d15-af18-75d2540332ac MTHSPL
SPL_SET_ID e57716ab-7697-46cc-b612-e0e81414128f MTHSPL
SPL_SET_ID f01caef0-61d4-42f9-890f-f2c776856f44 MTHSPL
SPL_SET_ID fc88377c-6580-4d03-befe-0c0b42d167ab MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~ebB.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWqB SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T000879628 MSH
TERMUI T000879629 MSH
TERMUI T287532 MSH
TERMUI T404097 MSH
TH BAN (19XX) MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (1996) MSH
TH NLM (2001) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3890^Active/Master NDFRT
VANDF_RECORD 50.6^3649^Active/Master NDFRT
VUID 4021218 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0663241

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