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| Terms & Properties |
Concept Unique Identifier (CUI): C0600327
NCI Thesaurus Code: C35498 (see NCI Thesaurus info)
Semantic Type: Disease or Syndrome
NCIt Definition: A rare acute life-threatening systemic bacterial noncontagious illness caused by any of several related staphylococcal exotoxins. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.
FDA Definition: A severe illness caused by infection with staphylococcus aureus and characterized by high fever of sudden onset, vomiting, diarrhea, and myalgia, followed by hypotension and in severe cases, shock; a sunburn-like rash with peeling of the skin, especially of the palms and soles, occurs during the acute phase.
NICHD Definition: Profoundly reduced blood flow that results in impaired tissue perfusion and possible end organ damage resulting from an exotoxin released from certain bacteria, most often Staphylococcus aureus, or Streptococcus pyogenes.
CSP Definition: syndrome characterized by high fever, vomiting, diarrhea, confusion, and skin rash; almost all cases have been related to an infection with toxin-producing Staphylococcus aureus.
Synonyms & Abbreviations: (see Synonym Details)
| Shock Syndrome (TSS), Toxic |
| Shock Syndrome, Toxic |
| Shock Syndromes, Toxic |
| SHOCK TOX |
| Shock, Toxic |
| Syndrome (TSS), Toxic Shock |
| SYNDROME TOXIC SHOCK |
| Syndrome, Toxic Shock |
| Syndromes, Toxic Shock |
| TOX SHOCK SYNDROME |
| Toxic shock syndrome (disorder) |
| Toxic shock syndrome NOS |
| Toxic Shock Syndrome, (TSS) |
| Toxic Shock Syndromes |
| toxic shock syndrome |
| toxic shock |
| TOXIC-SHOCK SYNDROME |
| TSS - Toxic shock syndrome |
| TSS, Toxic Shock Syndrome |
| TSS |
External Source Codes:
| NCI Thesaurus Code | C35498 (see NCI Thesaurus info) |
Other Properties:
| Name | Value | Source |
|---|---|---|
| ACTIVE | 1 | SNOMEDCT_US |
| CASE_SIGNIFICANCE_ID | 900000000000017005 | SNOMEDCT_US |
| CASE_SIGNIFICANCE_ID | 900000000000448009 | SNOMEDCT_US |
| CHARACTERISTIC_TYPE_ID | 900000000000011006 | SNOMEDCT_US |
| Contributing_Source | FDA | NCI |
| Contributing_Source | MedDRA | NCI |
| Contributing_Source | NICHD | NCI |
| CTV3ID | A3Ay1 | SNOMEDCT_US |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DID | 0368-3426 | CSP |
| EFFECTIVE_TIME | 20020131 | SNOMEDCT_US |
| EXCLUDES1 | endotoxic shock NOS (R57.8) | ICD10CM |
| EXCLUDES1 | sepsis NOS (A41.9) | ICD10CM |
| FDA_Table | Patient Code (Appendix B) | NCI |
| IAN | DEFAULT | ICD10 |
| ICA | Use additional code to identify the organism | ICD9CM |
| MODIFIER_ID | 900000000000451002 | SNOMEDCT_US |
| NICHD_Hierarchy_Term | Toxic Shock Syndrome | NCI |
| ORDER_NO | 00339 | ICD10CM |
| PRIMARY_PATH | 10044248$10021902$10021879$10021881$Toxic shock syndrome$Infections NEC$Infections - pathogen unspecified$Infections and infestations | MDR |
| PRIMARY_SOC | 10021881 | MDR |
| PT_IN_VERSION | 10.0 | MDR |
| PT_IN_VERSION | 10.1 | MDR |
| PT_IN_VERSION | 11.0 | MDR |
| PT_IN_VERSION | 11.1 | MDR |
| PT_IN_VERSION | 12.0 | MDR |
| PT_IN_VERSION | 12.1 | MDR |
| PT_IN_VERSION | 13.0 | MDR |
| PT_IN_VERSION | 13.1 | MDR |
| PT_IN_VERSION | 14.0 | MDR |
| PT_IN_VERSION | 14.1 | MDR |
| PT_IN_VERSION | 15.0 | MDR |
| PT_IN_VERSION | 15.1 | MDR |
| PT_IN_VERSION | 16.0 | MDR |
| PT_IN_VERSION | 16.1 | MDR |
| PT_IN_VERSION | 17.0 | MDR |
| PT_IN_VERSION | 17.1 | MDR |
| PT_IN_VERSION | 18.0 | MDR |
| PT_IN_VERSION | 18.1 | MDR |
| PT_IN_VERSION | 19.0 | MDR |
| PT_IN_VERSION | 19.1 | MDR |
| PT_IN_VERSION | 20.0 | MDR |
| PT_IN_VERSION | 20.1 | MDR |
| PT_IN_VERSION | 8.0 | MDR |
| PT_IN_VERSION | 8.1 | MDR |
| PT_IN_VERSION | 9.0 | MDR |
| PT_IN_VERSION | 9.1 | MDR |
| SMQ_TERM_ADDVERSION | 9.1 | MDR |
| SMQ_TERM_CAT | A | MDR |
| SMQ_TERM_LEVEL | 4 | MDR |
| SMQ_TERM_LEVEL | 5 | MDR |
| SMQ_TERM_LMVERSION | 9.1 | MDR |
| SMQ_TERM_SCOPE | 2 | MDR |
| SMQ_TERM_STATUS | A | MDR |
| SMQ_TERM_WEIGHT | 0 | MDR |
| SUBSET_MEMBER | 447562003~CORRELATIONID~447561005 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPADVICE~ALWAYS A48.3 | POSSIBLE REQUIREMENT FOR CAUSATIVE AGENT CODE | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPCATEGORYID~447637006 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPGROUP~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPPRIORITY~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPRULE~TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPTARGET~A48.3 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~CORRELATIONID~447561005 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~ALWAYS A48.3 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~IF STAPHYLOCOCCAL TOXIC SHOCK SYNDROME CHOOSE B95.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~IF STREPTOCOCCAL TOXIC SHOCK SYNDROME CHOOSE B95.5 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~IF TOXIC SHOCK SYNDROME DUE TO METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION CHOOSE B95.62 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~IF TOXIC SHOCK SYNDROME DUE TO METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS CHOOSE B95.61 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447637006 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447638001 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447639009 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPGROUP~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPGROUP~2 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~2 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~3 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~4 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~5 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~IFA 127411000119102 | Toxic shock syndrome due to methicillin susceptible Staphylococcus aureus | | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~IFA 127421000119109 | Toxic shock syndrome due to methicillin resistant Staphylococcus aureus infection | | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~IFA 240450004 | Staphylococcal toxic shock syndrome | | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~IFA 240451000 | Streptococcal toxic shock syndrome | | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~OTHERWISE TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~A48.3 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~B95.5 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~B95.61 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~B95.62 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~B95.8 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~ | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~A3Ay1 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000549004 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000549004 | SNOMEDCT_US |
| TERMUI | T037701 | MSH |
| TERMUI | T037702 | MSH |
| TH | POPLINE (1986) | MSH |
| TH | UNK (19XX) | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
| USE_ADDITIONAL | code to identify the organism (B95, B96) | ICD10CM |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0600327
