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Toxic Shock Syndrome (CUI C0600327) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0600327

NCI Thesaurus Code: C35498  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A rare acute life-threatening systemic bacterial noncontagious illness caused by any of several related staphylococcal exotoxins. It is characterized by high fever, hypotension, rash, multi-organ dysfunction, and cutaneous desquamation during the early convalescent period. The toxins affect the host immune system, causing an exuberant and pathological host inflammatory response. Laboratory findings include leukocytosis, elevated prothrombin time, hypoalbuminemia, hypocalcemia, and pyuria.

FDA Definition: A severe illness caused by infection with staphylococcus aureus and characterized by high fever of sudden onset, vomiting, diarrhea, and myalgia, followed by hypotension and in severe cases, shock; a sunburn-like rash with peeling of the skin, especially of the palms and soles, occurs during the acute phase.

NICHD Definition: Profoundly reduced blood flow that results in impaired tissue perfusion and possible end organ damage resulting from an exotoxin released from certain bacteria, most often Staphylococcus aureus, or Streptococcus pyogenes.

CSP Definition: syndrome characterized by high fever, vomiting, diarrhea, confusion, and skin rash; almost all cases have been related to an infection with toxin-producing Staphylococcus aureus.

Synonyms & Abbreviations: (see Synonym Details)
Shock Syndrome (TSS), Toxic
Shock Syndrome, Toxic
Shock Syndromes, Toxic
SHOCK TOX
Shock, Toxic
Syndrome (TSS), Toxic Shock
SYNDROME TOXIC SHOCK
Syndrome, Toxic Shock
Syndromes, Toxic Shock
TOX SHOCK SYNDROME
Toxic shock syndrome (disorder)
Toxic shock syndrome NOS
Toxic Shock Syndrome, (TSS)
Toxic Shock Syndromes
toxic shock syndrome
toxic shock
TOXIC-SHOCK SYNDROME
TSS - Toxic shock syndrome
TSS, Toxic Shock Syndrome
TSS

External Source Codes: 
NCI Thesaurus Code C35498 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source FDA NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID A3Ay1 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0368-3426 CSP
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 endotoxic shock NOS (R57.8) ICD10CM
EXCLUDES1 sepsis NOS (A41.9) ICD10CM
FDA_Table Patient Code (Appendix B) NCI
IAN DEFAULT ICD10
ICA Use additional code to identify the organism ICD9CM
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NICHD_Hierarchy_Term Toxic Shock Syndrome NCI
ORDER_NO 00339 ICD10CM
PRIMARY_PATH 10044248$10021902$10021879$10021881$Toxic shock syndrome$Infections NEC$Infections - pathogen unspecified$Infections and infestations MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
SMQ_TERM_ADDVERSION 9.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 9.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS A48.3 | POSSIBLE REQUIREMENT FOR CAUSATIVE AGENT CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~A48.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS A48.3 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF STAPHYLOCOCCAL TOXIC SHOCK SYNDROME CHOOSE B95.8 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF STREPTOCOCCAL TOXIC SHOCK SYNDROME CHOOSE B95.5 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF TOXIC SHOCK SYNDROME DUE TO METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION CHOOSE B95.62 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF TOXIC SHOCK SYNDROME DUE TO METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS CHOOSE B95.61 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 127411000119102 | Toxic shock syndrome due to methicillin susceptible Staphylococcus aureus | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 127421000119109 | Toxic shock syndrome due to methicillin resistant Staphylococcus aureus infection | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 240450004 | Staphylococcal toxic shock syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 240451000 | Streptococcal toxic shock syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~A48.3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B95.5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B95.61 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B95.62 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B95.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~A3Ay1 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T037701 MSH
TERMUI T037702 MSH
TH POPLINE (1986) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code to identify the organism (B95, B96) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0600327

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