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Ewings sarcoma (CUI C0553580) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0553580

NCI Thesaurus Code: C4817  (see NCI Thesaurus info)

Semantic Type: Neoplastic Process

NCIt Definition: A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms.

GARD Definition: Ewing's sarcoma is a malignant (cancerous) bone tumor that affects children. It can occur any time during childhood and young adulthood, but usually develops during puberty, when bones are growing rapidly. The tumor may arise anywhere in the body, usually in the long bones of the arms and legs, the pelvis, or the chest. It may also develop in the skull or the flat bones of the trunk. There are few symptoms. The most common is pain and occasionally swelling at the site of the tumor. Fever may also be present. The tumor often spreads (metastasis) to the lungs and other bones. The cause of Ewing's sarcoma is unknown. - this information is from GARD/ORDR/NCATS.

PDQ Definition: A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation. It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor. It affects mostly males under age 20, and it can occur in soft tissue or bone. Pain and the presence of a mass are the most common clinical symptoms. -- 2004 Check for active clinical trials using this agent. (NCI Thesaurus)

HPO Definition: A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. [HPO:probinson, pmid:17272319]

NICHD Definition: A malignant neoplasm of the bone, or the soft tissue adjacent to bone, that is comprised of primitive neuroectodermal cells.

NCI-GLOSS Definition: A type of cancer that forms in bone or soft tissue.

CSP Definition: malignant tumor of bones which always arises in medullary tissue, occurring more often in cylindrical bones, with pain, fever, and leukocytosis.

MSH Definition: A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.

Synonyms & Abbreviations: (see Synonym Details)
ES
Ewing Sarcoma
Ewing Sarkom
EWING TUMOR
Ewing's sarcoma (morphologic abnormality)
Ewing's sarcoma NOS
Ewing's sarcoma stage unspecified
Ewing's Sarcoma
Ewing's tumor
Ewing's tumour
Ewings Sarcoma
Ewings Tumor
Sarcoma, Ewing [Disease/Finding]
Sarcoma, Ewing's
Sarcoma, Ewings
SARCOMA, EWING
Tumor, Ewing's
Tumor, Ewing

External Source Codes: 
NCI Thesaurus Code C4817 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate IM with BONE NEOPLASMS (IM) or specific bone/neoplasm term (IM) or specific bone (IM) + BONE NEOPLASMS (IM) MSH
AQL BL BS CF CH CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SC SE SU TH UL UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
Contributing_Source CTRP NCI
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID BBY0. SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2013-04-07T01:54:14Z HPO
DATE_FIRST_PUBLISHED 2007-05-04 PDQ
DATE_LAST_MODIFIED 2007-05-02 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2008-4746 CSP
DISEASE_IDENTIFIER_ID 18402 GARD
DISEASE_IDENTIFIER_ID 18403 GARD
DISEASE_IDENTIFIER_ID 18404 GARD
DISEASE_IDENTIFIER_ID 18405 GARD
DX 20120101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D018241 MSH
GENELOCUS ,2,2,q,1,2, OMIM
GENESYMBOL EWSR1 OMIM
GENESYMBOL EWS OMIM
HAS_GARD_PAGE true GARD
HN 2012 (1963) MSH
HPO_COMMENT Histologically, Ewing's sarcoma is composed of a homogeneous population of small round cells with high nuclear to cytoplasmic ratios that are arrayed in sheets. There is scant cytoplasms, which is pale, vacuolated and characterized by faded boundaries. In contrast, the nuclei are clearly visualized by their intense color. Mitotic activity is typically low. HPO
ICD-O-3_Code 9260/3 NCI
ICD-O-3_CODE 9260/3 SNOMEDCT_US
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. NDFRT
MESH_DUI D012512 NDFRT
MESH_NAME Sarcoma, Ewing NDFRT
MESH_UI M0019433 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20130708 MSH
MN C04.557.450.565.575.650.800 MSH
MN C04.557.450.795.620.800 MSH
NCI_THESAURUS_CODE C4817 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
Neoplastic_Status Malignant NCI
NICHD_Hierarchy_Term Ewing Sarcoma NCI
NUI N0000002674 NDFRT
ORIG_STY Neoplasm diagnosis PDQ
PM 2012; use SARCOMA, EWING'S 1963-2011 MSH
PRIMARY_PATH 10015560$10039498$10040778$10029104$Ewing's sarcoma$Bone sarcomas$Skeletal neoplasms malignant and unspecified$Neoplasms benign, malignant and unspecified (incl cysts and polyps) MDR
PRIMARY_SOC 10029104 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6390/ewings-sarcoma/resources/1 GARD
RXAUI 3156152 RXNORM
RXAUI 4222799 RXNORM
RXAUI 4223820 RXNORM
RXAUI 4223821 RXNORM
RXAUI 4223822 RXNORM
RXAUI 5930860 RXNORM
RXAUI 5930861 RXNORM
RXCUI 1023147 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 20.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 76909002 NDFRT
SUBSET_MEMBER 446608001~MAPTARGET~9260/3 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~BBY0. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERM_LEVEL 4 ICDO
TERM_LEVEL Synonym ICDO
TERMUI T037123 MSH
TERMUI T037124 MSH
TERMUI T786162 MSH
TERMUI T786163 MSH
TERMUI T841349 MSH
TERMUI T841350 MSH
TH GHR (2014) MSH
TH NLM (1966) MSH
TH NLM (2012) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0553580

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