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Metabolic Syndrome X (CUI C0524620) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0524620

NCI Thesaurus Code: C84442  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A combination of medical conditions that, when present, increase the risk of heart attack, stroke, and diabetes mellitus. It includes the following medical conditions: increased blood pressure, central obesity, abnormal cholesterol levels, and elevated fasting glucose.

HL7V3.0 Definition: 

A collection of metabolic risk factors in one individual. The root causes of metabolic syndrome are overweight / obesity, physical inactivity, and genetic factors. Various risk factors have been included in metabolic syndrome. Factors generally accepted as being characteristic of this syndrome include abdominal obesity, atherogenic dyslipidemia, raised blood pressure, insulin resistence with or without glucose intolerance, prothrombotic state, and proinflammatory state.

MEDLINEPLUS Definition: 

Metabolic syndrome is a group of conditions that put you at risk for heart disease and diabetes. These conditions are

Not all doctors agree on the definition or cause of metabolic syndrome. The cause might be insulin resistance. Insulin is a hormone your body produces to help you turn sugar from food into energy for your body. If you are insulin resistant, too much sugar builds up in your blood, setting the stage for disease.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

NCI-GLOSS Definition: A condition is marked by extra fat around the abdomen, high levels of blood glucose (sugar) when not eating, high levels of triglycerides (a type of fat) in the blood, low levels of high-density lipoproteins (a type of protein that carries fats) in the blood, and high blood pressure. People with metabolic syndrome are at increased risk of diabetes mellitus and diseases of the heart and blood vessels.

CSP Definition: a multifaceted syndrome characterized by clustering of insulin resistance and hyperinsulinemia, associated with dyslipidemia, essential hypertension, abdominal obesity, glucose intolerance or noninsulin dependent diabetes mellitus, and an increased risk of cardiovascular events.

MSH Definition: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)

Synonyms & Abbreviations: (see Synonym Details)
Cardiovascular Syndrome, Metabolic
Cardiovascular Syndromes, Metabolic
dysmetabolic syndrome X
Dysmetabolic syndrome
Insulin Resistance Syndrome X
Insulin resistance syndrome
Metabolic Cardiovascular Syndrome
Metabolic syndrome X (disorder)
Metabolic Syndrome X [Disease/Finding]
metabolic syndrome X
metabolic syndrome
Metabolic X Syndrome
Reaven syndrome X
Reaven's syndrome
Syndrome X (Metabolic)
Syndrome X, Dysmetabolic
Syndrome X, Insulin Resistance
Syndrome X, Metabolic
Syndrome X, Reaven
Syndrome, Metabolic Cardiovascular
Syndrome, Metabolic X
X Syndrome, Metabolic

External Source Codes: 
NCI Thesaurus Code C84442 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with SYNDROME X, CARDIAC or X SYNDROME, ANGINA see MICROVASCULAR ANGINA MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
Contributing_Source CTRP NCI
CTV3ID X40JE SNOMEDCT_US
DATE_CREATED 07/21/2003 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_FIRST_PUBLISHED 2009-06-11 PDQ
DATE_LAST_MODIFIED 2009-06-11 PDQ
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 5003-0027 CSP
DISEASE_IDENTIFIER_ID 3763 GARD
DX 20020101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D003924 MSH
FX D017566 MSH
HL7AI false HL7V3.0
HL7CC false HL7V3.0
HL7CO Sponsor HL7V3.0
HL7MI false HL7V3.0
HL7NO Is NOT in UMLS. HL7V3.0
HL7RD 2015-07-31 HL7V3.0
HL7RG WHICH HL7V3.0
HL7SL en HL7V3.0
HN 2002; for REAVEN SYNDROME X use INSULIN RESISTANCE 1998-2001 MSH
ICA Use additional code for associated manifestation, such as: {cardiovascular disease (414.00-414.07); obesity (278.00-278.03)} ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
MDA 20010725 MSH
MESH_DEFINITION A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556) NDFRT
MESH_DUI D024821 NDFRT
MESH_NAME Metabolic Syndrome X NDFRT
MESH_UI M0011433 NDFRT
MMR 20120703 MSH
MN C18.452.394.968.500.570 MSH
MN C18.452.625 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/metabolicsyndrome.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/metabolicsyndrome.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Diabetes and Digestive and Kidney Diseases http://www.niddk.nih.gov/ MEDLINEPLUS
NCI_THESAURUS_CODE C84442 PDQ
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000010963 NDFRT
ORDER_NO 04790 ICD10CM
ORIG_STY Secondary related condition PDQ
PM 2002; for REAVEN SYNDROME X see INSULIN RESISTANCE 1998-2001 MSH
PRIMARY_PATH 10052066$10027428$10000546$10027433$Metabolic syndrome$Metabolic disorders NEC$Metabolism disorders NEC$Metabolism and nutrition disorders MDR
PRIMARY_SOC 10027433 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3149537 RXNORM
RXAUI 3181678 RXNORM
RXAUI 3197934 RXNORM
RXAUI 3197961 RXNORM
RXAUI 3197962 RXNORM
RXAUI 3197963 RXNORM
RXAUI 3229152 RXNORM
RXAUI 3242057 RXNORM
RXAUI 3242058 RXNORM
RXCUI 1023698 RXNORM
SMQ_TERM_ADDVERSION 11.1 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 237602007 NDFRT
SNOMEDID DB-61052 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS E88.8 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~E88.8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS E88.81 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~E88.81 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X40JE SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DB-61052 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T021958 MSH
TERMUI T427848 MSH
TERMUI T427850 MSH
TERMUI T427851 MSH
TERMUI T427908 MSH
TERMUI T533768 MSH
TERMUI T533769 MSH
TERMUI T535798 MSH
TH NLM (1998) MSH
TH NLM (2002) MSH
TH NLM (2004) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL codes for associated manifestations, such as: ICD10CM
USE_ADDITIONAL obesity (E66.-) ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0524620

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