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Cefditoren (CUI C0287573) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0287573

NCI Thesaurus Code: C72625  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A semisynthetic, broad-spectrum, beta-lactamase-resistant, third-generation cephalosporin with antibacterial activity. Cefditoren binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Synonyms & Abbreviations: (see Synonym Details)
Cefditoren (substance)
cefditoren [Chemical/Ingredient]
Cefditoren
Product containing cefditoren (medicinal product)
Product containing cefditoren

External Source Codes: 
NCI Thesaurus Code C72625 (see NCI Thesaurus info)
CAS Registry Number 104145-95-1 (see NLM ChemIDplus info)
FDA UNII Code 81QS09V3YW

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:59343 NCI
Chemical_Formula C19H18N6O5S3 NCI
Contributing_Source FDA NCI
CTV3ID XUr1P SNOMEDCT_US
CTV3ID XUUWq SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20150731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 81QS09V3YW DRUGBANK
FDA_UNII_CODE 81QS09V3YW NDFRT
FR 107 MSH
HM D002511 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19920411 MSH
MESH_DUI C073460 NDFRT
MESH_NAME cefditoren NDFRT
MESH_UI M0198635 NDFRT
MMR 20121105 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000010085 NDFRT
NUI N0000022252 NDFRT
PA D000900 MSH
RN 81QS09V3YW MSH
RR 104145-95-1 (cefditoren) MSH
RR 104146-53-4 (Na salt (6R-(3(Z),6alpha,7beta(Z)))-isomer) MSH
RXAUI 2627485 RXNORM
RXAUI 3122599 RXNORM
RXAUI 3122600 RXNORM
RXAUI 3259682 RXNORM
RXAUI 3259683 RXNORM
RXAUI 6395117 RXNORM
RXAUI 676614 RXNORM
RXCUI 83682 RXNORM
SC 1 MSH
SID APRD00850 DRUGBANK
SOS structure given in first source; RN given refers to the (6R-(3(Z),6alpha,7beta(Z)))-isomer MSH
SPL_SET_ID 1c90b649-5536-417c-82cb-89663137f14f MTHSPL
SPL_SET_ID d5050d0e-81d1-4707-a38a-e80de2aebf09 MTHSPL
SRC Diagn Microbiol Infect Dis 1991 Sep-Oct;14(5):417-24 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUr1P SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUUWq SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T228640 MSH
TH FDA SRS (2013) MSH
TH INN (19XX) MSH
TH USAN (1995) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.6^3744^Active/Master NDFRT
VUID 4024247 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0287573

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