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| Terms & Properties |
Concept Unique Identifier (CUI): C0242770
NCI Thesaurus Code: C62586 (see NCI Thesaurus info)
Semantic Type: Disease or Syndrome
NCIt Definition: A form of organizing pneumonia with a non-infectious etiology. Excessive proliferation of granulation tissue occurs in alveolar ducts and alveoli and primarily causes injury to alveolar walls, but bronchioles may be affected.
RADLEX Definition: A disease formerly considered a form of interstitial pneumonia. Its etiology is obscure but it may be associated with toxic fumes, infection, and connective tissue disease. Clinical symptoms include cough, dyspnea and influenza-like symptoms with the development of the usual interstitial pneumonia in many cases. Obstructive symptoms are limited to smokers. There are patchy polypoid masses of intra-alveolar granulation tissue in small airway lumina and alveolar ducts. ""Organizing"" refers to unresolved pneumonia (in which the alveolar exudate persists and eventually undergoes fibrosis) in which fibrous tissue forms in the alveoli. (From Segen, Dictionary of Modern Medicine, 1992; Stedman, 25th ed) [MeSH]Pathology. - Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias (5), but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Radiographs and CT scans. - Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal (Fig 45) and sometimes bronchocentric (96). Other manifestations of organizing pneumonia include ground-glass opacity, tree-in-bud pattern, and nodular opacities (37). [Fleischner Society]
GARD Definition: Cryptogenic organizing pneumonia (COP) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. COP often affects adults in midlife (40 to 60 years of age). No predisposing factors have been identified and the cause is often unknown. Diagnosis may be made through computed tomography (CT) scan or lung biopsy. Response to treatment with corticosteroids is generally favorable. - this information is from GARD/ORDR/NCATS.
GARD Definition: Bronchiolitis obliterans organizing pneumonia (BOOP) is a lung disease that causes inflammation in the small air tubes (bronchioles) and air sacs (alveoli). The signs and symptoms of BOOP often include shortness of breath, a dry cough, and fever. BOOP can be caused by viral infections, various drugs, and other medical conditions. If the cause is known, the condition is called secondary BOOP. In many cases, the underlying cause of BOOP is unknown. These cases are called idiopathic BOOP or cryptogenic organizing pneumonia. Treatment often includes corticosteroid medications. - this information is from GARD/ORDR/NCATS.
HPO Definition: Bronchiolitis obliterans organizing pneumonia (BOOP) is and interstitial lung abnormalitiy characterized histopathologically by plugs of granulation tissue lying within small airways, alveolar ducts, and alveoli and by chronic inflammatory cell infiltration in alveolar walls. Patients with BOOP generally present with subacute illness, including shortness of breath, fever, malaise, and weight loss. [DDD:tkuijpers, HPO:probinson, pmid:20858818]
MSH Definition: An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Synonyms & Abbreviations: (see Synonym Details)
| BOOP - Bronchiolitis obliterans organising pneumonia |
| BOOP - Bronchiolitis obliterans organizing pneumonia |
| BOOP |
| Bronchiolitis obliterans organising pneumonia |
| Bronchiolitis obliterans organizing pneumonia (disorder) |
| Bronchiolitis obliterans organizing pneumonia |
| Bronchiolitis obliterans with obstructive pulmonary disease |
| Bronchiolitis obliterans with organising pneumonia |
| Bronchiolitis obliterans with organizing pneumonia |
| COP - Cryptogenic organising pneumonitis |
| COP - Cryptogenic organizing pneumonitis |
| COP |
| Cryptogenic organising pneumonia |
| Cryptogenic organiz pneu |
| Cryptogenic organizing pneumonia (disorder) |
| Cryptogenic Organizing Pneumonia [Disease/Finding] |
| Cryptogenic Organizing Pneumonias |
| Cryptogenic organizing pneumonia |
| Idiopathic BOOP |
| Idiopathic bronchiolitis obliterans organizing pneumonia |
| Kryptogene organisierende Pneumonie |
| Organizing Pneumonia, Cryptogenic |
| Organizing Pneumonias, Cryptogenic |
| Pneumonia, Cryptogenic Organizing |
| Pneumonias, Cryptogenic Organizing |
External Source Codes:
| NCI Thesaurus Code | C62586 (see NCI Thesaurus info) |
Other Properties:
| Name | Value | Source |
|---|---|---|
| ACTIVE | 1 | SNOMEDCT_US |
| AN | note entry term BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA: do not confuse with BRONCHIOLITIS OBLITERANS | MSH |
| AQL | BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI | MSH |
| CASE_SIGNIFICANCE_ID | 900000000000017005 | SNOMEDCT_US |
| CASE_SIGNIFICANCE_ID | 900000000000020002 | SNOMEDCT_US |
| CITE | Fleischner Society | RADLEX |
| CTV3ID | X102j | SNOMEDCT_US |
| CTV3ID | XUttX | SNOMEDCT_US |
| DATE_CREATED | 2012-06-18T07:55:41Z | HPO |
| DATE_CREATED | 2013-01-09T00:04:00 | GARD |
| DATE_CREATED | 2015-01-22T00:04:00 | GARD |
| DATE_LAST_MODIFIED | 2013-01-09T00:04:00 | GARD |
| DC | 1 | MSH |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DISEASE_IDENTIFIER_ID | 17592 | GARD |
| DISEASE_IDENTIFIER_ID | 30530 | GARD |
| DISEASE_IDENTIFIER_ID | 30531 | GARD |
| DISEASE_IDENTIFIER_ID | 8773 | GARD |
| DISEASE_IDENTIFIER_ID | 8774 | GARD |
| DISEASE_IDENTIFIER_ID | 8775 | GARD |
| DX | 19950101 | MSH |
| EFFECTIVE_TIME | 20020131 | SNOMEDCT_US |
| EFFECTIVE_TIME | 20170131 | SNOMEDCT_US |
| EXCLUDES1 | organizing pneumonia NOS, or due to known underlying cause (J84.89) | ICD10CM |
| HAS_GARD_PAGE | true | GARD |
| HN | 2009 (1995) | MSH |
| IDENTIFIER_SOURCE | Orp | GARD |
| IDENTIFIER_TYPE_ID | 1 | GARD |
| IS_ACTIVE | true | GARD |
| IS_RARE | true | GARD |
| IS_SPANISH | false | GARD |
| MDA | 19940125 | MSH |
| MESH_DEFINITION | An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts. | NDFRT |
| MESH_DUI | D018549 | NDFRT |
| MESH_NAME | Cryptogenic Organizing Pneumonia | NDFRT |
| MESH_UI | M0027812 | NDFRT |
| MMR | 20080708 | MSH |
| MN | C08.127.446.135.140.200 | MSH |
| MN | C08.381.483.487.249 | MSH |
| MN | C08.381.495.146.135.140.200 | MSH |
| NDFRT_KIND | DISEASE_KIND | NDFRT |
| NUI | N0000003833 | NDFRT |
| ORDER_NO | 12683 | ICD10CM |
| PM | 2009; see BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA 1995-2008 | MSH |
| PT_IN_VERSION | 10.0 | MDR |
| PT_IN_VERSION | 10.1 | MDR |
| PT_IN_VERSION | 11.0 | MDR |
| PT_IN_VERSION | 8.0 | MDR |
| PT_IN_VERSION | 8.1 | MDR |
| PT_IN_VERSION | 9.0 | MDR |
| PT_IN_VERSION | 9.1 | MDR |
| RARE_DISEASE_URL | http://rarediseases.info.nih.gov/gard/1620/cryptogenic-organizing-pneumonia/resources/1 | GARD |
| RARE_DISEASE_URL | http://rarediseases.info.nih.gov/gard/5961/bronchiolitis-obliterans-organizing-pneumonia/resources/1 | GARD |
| RXAUI | 3115434 | RXNORM |
| RXAUI | 3286816 | RXNORM |
| RXAUI | 3287025 | RXNORM |
| RXAUI | 3287026 | RXNORM |
| RXCUI | 1026228 | RXNORM |
| SMQ_TERM_ADDVERSION | 10.0 | MDR |
| SMQ_TERM_ADDVERSION | 12.0 | MDR |
| SMQ_TERM_ADDVERSION | 9.0 | MDR |
| SMQ_TERM_ADDVERSION | 9.1 | MDR |
| SMQ_TERM_CAT | A | MDR |
| SMQ_TERM_CAT | C | MDR |
| SMQ_TERM_LEVEL | 5 | MDR |
| SMQ_TERM_LMVERSION | 10.0 | MDR |
| SMQ_TERM_LMVERSION | 11.1 | MDR |
| SMQ_TERM_LMVERSION | 12.0 | MDR |
| SMQ_TERM_LMVERSION | 9.0 | MDR |
| SMQ_TERM_LMVERSION | 9.1 | MDR |
| SMQ_TERM_SCOPE | 1 | MDR |
| SMQ_TERM_STATUS | A | MDR |
| SMQ_TERM_WEIGHT | 0 | MDR |
| SNOMED_CID | 129458007 | NDFRT |
| SNOMEDID | D2-60651 | SNOMEDCT_US |
| SNOMEDID | R0-00308 | SNOMEDCT_US |
| SOS | Excludes: organizing pneumonia NOS, or due to known underlying cause (516.8) | ICD9CM |
| SUBSET_MEMBER | 447562003~CORRELATIONID~447561005 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPADVICE~ALWAYS J84.1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPCATEGORYID~447637006 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPGROUP~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPPRIORITY~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPRULE~TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPTARGET~J84.1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~CORRELATIONID~447561005 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~ALWAYS J84.89 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~IF SEASONAL CRYPTOGENIC ORGANIZING PNEUMONIA WITH BIOCHEMICAL CHOLESTASIS CHOOSE J84.116 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~IF SEASONAL CRYPTOGENIC ORGANIZING PNEUMONIA WITH BIOCHEMICAL CHOLESTASIS CHOOSE K71.0 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447637006 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447638001 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447639009 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPGROUP~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPGROUP~2 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~2 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~IFA 233713004 | Seasonal cryptogenic organizing pneumonia with biochemical cholestasis (disorder) | | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~OTHERWISE TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~J84.116 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~J84.89 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~K71.0 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~ | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~X102j | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~XUttX | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000498005~MAPTARGET~D2-60651 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000498005~MAPTARGET~R0-00308 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000549004 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000549004 | SNOMEDCT_US |
| TERMUI | T055217 | MSH |
| TERMUI | T055218 | MSH |
| TERMUI | T703060 | MSH |
| TH | NLM (1995) | MSH |
| TH | NLM (2009) | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0242770
