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Bronchiolitis Obliterans Organizing Pneumonia (CUI C0242770) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0242770

NCI Thesaurus Code: C62586  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A form of organizing pneumonia with a non-infectious etiology. Excessive proliferation of granulation tissue occurs in alveolar ducts and alveoli and primarily causes injury to alveolar walls, but bronchioles may be affected.

RADLEX Definition: A disease formerly considered a form of interstitial pneumonia. Its etiology is obscure but it may be associated with toxic fumes, infection, and connective tissue disease. Clinical symptoms include cough, dyspnea and influenza-like symptoms with the development of the usual interstitial pneumonia in many cases. Obstructive symptoms are limited to smokers. There are patchy polypoid masses of intra-alveolar granulation tissue in small airway lumina and alveolar ducts. ""Organizing"" refers to unresolved pneumonia (in which the alveolar exudate persists and eventually undergoes fibrosis) in which fibrous tissue forms in the alveoli. (From Segen, Dictionary of Modern Medicine, 1992; Stedman, 25th ed) [MeSH]Pathology. - Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias (5), but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Radiographs and CT scans. - Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal (Fig 45) and sometimes bronchocentric (96). Other manifestations of organizing pneumonia include ground-glass opacity, tree-in-bud pattern, and nodular opacities (37). [Fleischner Society]

GARD Definition: Cryptogenic organizing pneumonia (COP) is a rapidly developing inflammatory lung disease characterized by flu-like symptoms including cough, fever, malaise, fatigue and weight loss. COP often affects adults in midlife (40 to 60 years of age). No predisposing factors have been identified and the cause is often unknown. Diagnosis may be made through computed tomography (CT) scan or lung biopsy. Response to treatment with corticosteroids is generally favorable. - this information is from GARD/ORDR/NCATS.

GARD Definition: Bronchiolitis obliterans organizing pneumonia (BOOP) is a lung disease that causes inflammation in the small air tubes (bronchioles) and air sacs (alveoli). The signs and symptoms of BOOP often include shortness of breath, a dry cough, and fever. BOOP can be caused by viral infections, various drugs, and other medical conditions. If the cause is known, the condition is called secondary BOOP. In many cases, the underlying cause of BOOP is unknown. These cases are called idiopathic BOOP or cryptogenic organizing pneumonia. Treatment often includes corticosteroid medications. - this information is from GARD/ORDR/NCATS.

HPO Definition: Bronchiolitis obliterans organizing pneumonia (BOOP) is and interstitial lung abnormalitiy characterized histopathologically by plugs of granulation tissue lying within small airways, alveolar ducts, and alveoli and by chronic inflammatory cell infiltration in alveolar walls. Patients with BOOP generally present with subacute illness, including shortness of breath, fever, malaise, and weight loss. [DDD:tkuijpers, HPO:probinson, pmid:20858818]

MSH Definition: An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.

Synonyms & Abbreviations: (see Synonym Details)
BOOP - Bronchiolitis obliterans organising pneumonia
BOOP - Bronchiolitis obliterans organizing pneumonia
BOOP
Bronchiolitis obliterans organising pneumonia
Bronchiolitis obliterans organizing pneumonia (disorder)
Bronchiolitis obliterans organizing pneumonia
Bronchiolitis obliterans with obstructive pulmonary disease
Bronchiolitis obliterans with organising pneumonia
Bronchiolitis obliterans with organizing pneumonia
COP - Cryptogenic organising pneumonitis
COP - Cryptogenic organizing pneumonitis
COP
Cryptogenic organising pneumonia
Cryptogenic organiz pneu
Cryptogenic organizing pneumonia (disorder)
Cryptogenic Organizing Pneumonia [Disease/Finding]
Cryptogenic Organizing Pneumonias
Cryptogenic organizing pneumonia
Idiopathic BOOP
Idiopathic bronchiolitis obliterans organizing pneumonia
Kryptogene organisierende Pneumonie
Organizing Pneumonia, Cryptogenic
Organizing Pneumonias, Cryptogenic
Pneumonia, Cryptogenic Organizing
Pneumonias, Cryptogenic Organizing

External Source Codes: 
NCI Thesaurus Code C62586 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN note entry term BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA: do not confuse with BRONCHIOLITIS OBLITERANS MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CITE Fleischner Society RADLEX
CTV3ID X102j SNOMEDCT_US
CTV3ID XUttX SNOMEDCT_US
DATE_CREATED 2012-06-18T07:55:41Z HPO
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DISEASE_IDENTIFIER_ID 17592 GARD
DISEASE_IDENTIFIER_ID 30530 GARD
DISEASE_IDENTIFIER_ID 30531 GARD
DISEASE_IDENTIFIER_ID 8773 GARD
DISEASE_IDENTIFIER_ID 8774 GARD
DISEASE_IDENTIFIER_ID 8775 GARD
DX 19950101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20170131 SNOMEDCT_US
EXCLUDES1 organizing pneumonia NOS, or due to known underlying cause (J84.89) ICD10CM
HAS_GARD_PAGE true GARD
HN 2009 (1995) MSH
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19940125 MSH
MESH_DEFINITION An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts. NDFRT
MESH_DUI D018549 NDFRT
MESH_NAME Cryptogenic Organizing Pneumonia NDFRT
MESH_UI M0027812 NDFRT
MMR 20080708 MSH
MN C08.127.446.135.140.200 MSH
MN C08.381.483.487.249 MSH
MN C08.381.495.146.135.140.200 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000003833 NDFRT
ORDER_NO 12683 ICD10CM
PM 2009; see BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA 1995-2008 MSH
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/1620/cryptogenic-organizing-pneumonia/resources/1 GARD
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5961/bronchiolitis-obliterans-organizing-pneumonia/resources/1 GARD
RXAUI 3115434 RXNORM
RXAUI 3286816 RXNORM
RXAUI 3287025 RXNORM
RXAUI 3287026 RXNORM
RXCUI 1026228 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 12.0 MDR
SMQ_TERM_ADDVERSION 9.0 MDR
SMQ_TERM_ADDVERSION 9.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT C MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.0 MDR
SMQ_TERM_LMVERSION 11.1 MDR
SMQ_TERM_LMVERSION 12.0 MDR
SMQ_TERM_LMVERSION 9.0 MDR
SMQ_TERM_LMVERSION 9.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 129458007 NDFRT
SNOMEDID D2-60651 SNOMEDCT_US
SNOMEDID R0-00308 SNOMEDCT_US
SOS Excludes: organizing pneumonia NOS, or due to known underlying cause (516.8) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS J84.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~J84.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS J84.89 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SEASONAL CRYPTOGENIC ORGANIZING PNEUMONIA WITH BIOCHEMICAL CHOLESTASIS CHOOSE J84.116 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SEASONAL CRYPTOGENIC ORGANIZING PNEUMONIA WITH BIOCHEMICAL CHOLESTASIS CHOOSE K71.0 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 233713004 | Seasonal cryptogenic organizing pneumonia with biochemical cholestasis (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~J84.116 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~J84.89 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~K71.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X102j SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUttX SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D2-60651 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~R0-00308 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T055217 MSH
TERMUI T055218 MSH
TERMUI T703060 MSH
TH NLM (1995) MSH
TH NLM (2009) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0242770

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