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Necrotizing fasciitis (CUI C0238124) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0238124

NCI Thesaurus Code: C84916  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Infection of the deep skin and subcutaneous tissues and necrosis of the fascia. It is caused by bacteria including group A streptococcus, Staphylococcus aureus and Clostridium perfringens. It may develop following trauma and invasive procedures.

RADLEX Definition: A fulminating group A streptococcal infection beginning with severe or extensive cellulitis that spreads to involve the superficial and deep fascia, producing thrombosis of the subcutaneous vessels and gangrene of the underlying tissues. A cutaneous lesion usually serves as a portal of entry for the infection, but sometimes no such lesion is found. (Dorland, 28th ed) [MeSH]

GARD Definition: Necrotizing fasciitis is a serious bacterial infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. The infection can be sudden and fast-spreading. The bacteria involved enters the body through an external injury and attacks the surrounding tissues, eventually causing them to die. Early signs include flu-like symptoms and redness or pain around the infection site, followed by very high fever, severe pain, swelling and blistering. If the infection is not treated promptly, it may cause multiple organ failure and death. Treatment typically includes intravenous antibiotics; surgery to remove infected and dead tissue; hyperbaric oxygen therapy; and intravenous immune globulin therapy. - this information is from GARD/ORDR/NCATS.

NICHD Definition: Infection and necrosis of the fascia and adjoining tissues.

MSH Definition: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.

Synonyms & Abbreviations: (see Synonym Details)
Fasciitides, Necrotizing
Fasciitis necrotising
Fasciitis necrotizing
Fasciitis, Necrotizing [Disease/Finding]
FASCIITIS, NECROTIZING
Fascitides, Necrotizing
Fascitis, Necrotizing
GANGRENE, HEMOLYTIC STREPTOCOCCUS
Necrotising cellulitis
Necrotising fasciitis NOS
Necrotising fasciitis
Necrotising myositis
Necrotizing cellulitis
Necrotizing Fasciitides
Necrotizing fasciitis (disorder)
Necrotizing fasciitis NOS
Necrotizing fasciitis
Necrotizing Fascitides
Necrotizing Fascitis
Necrotizing myositis
Nekrotisierende Fasziitis

External Source Codes: 
NCI Thesaurus Code C84916 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate IM with specific bacterial infection term (IM), often Streptococcal infection caused by Streptococcus pyogenes MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID X5013 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DX 19960101 MSH
EFFECTIVE_TIME 20160131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 96 MSH
IAN DEFAULT ICD10
ICA Use additional code to identify: {infectious organism (041.00-041.89); gangrene (785.4), if applicable} ICD9CM
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-01-19T00:00:00 GARD
MDA 19950605 MSH
MESH_DEFINITION A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common. NDFRT
MESH_DUI D019115 NDFRT
MESH_NAME Fasciitis, Necrotizing NDFRT
MESH_UI M0028525 NDFRT
MMR 20090706 MSH
MN C01.252.825.340 MSH
MN C05.321.550 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Necrotizing Fasciitis NCI
NUI N0000003896 NDFRT
ORDER_NO 19955 ICD10CM
PM 96 MSH
PRIMARY_PATH 10028885$10057192$10021879$10021881$Necrotising fasciitis$Muscle and soft tissue infections$Infections - pathogen unspecified$Infections and infestations MDR
PRIMARY_PATH 10074769$10028640$10028302$10028395$Necrotising myositis$Myopathies$Muscle disorders$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10021881 MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6454/necrotizing-fasciitis/resources/1 GARD
RXAUI 3159896 RXNORM
RXAUI 3159897 RXNORM
RXAUI 3159912 RXNORM
RXCUI 1021934 RXNORM
SMQ_TERM_ADDVERSION 17.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_CAT C MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 17.0 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 52486002 NDFRT
SNOMEDID DE-14230 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M72.69 | POSSIBLE REQUIREMENT FOR CAUSATIVE AGENT CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M72.69 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M72.6 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF NECROTIZING FASCIITIS CAUSED BY STREPTOCOCCUS PYOGENES CHOOSE B95.5 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 449900006 | Necrotizing fasciitis caused by Streptococcus pyogenes (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B95.5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M72.6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X5013 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DE-14230 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T057074 MSH
TERMUI T057075 MSH
TH NLM (1996) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
USE_ADDITIONAL code (B95.-, B96.-) to identify causative organism ICD10CM

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0238124

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