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Pick Disease of the Brain (CUI C0236642) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0236642

NCI Thesaurus Code: C85008  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A rare neurodegenerative disorder leading to dementia. It is characterized by frontotemporal lobar degeneration with accumulation of tau proteins which form Pick bodies.

GARD Definition: Pick's disease is a neurological condition characterized by a slowly progressive deterioration of behavior, personality, or language. People with Pick's disease have abnormal substances (called Pick bodies) inside nerve cells in the damaged areas of the brain. Pick bodies contain an abnormal form of a protein called tau. This protein is found in all nerve cells, but people with Pick's disease have an abnormal amount or type of this protein. Symptoms often present sometime in the 50s, though it can occur as early as age 20 or as late as age 80. The course of the disease varies from person to person. The underlying cause of Pick's disease is unknown. In some cases, the disease runs in families. While there is no treatment to slow the progression of the disease, medications can be used to treat individual symptoms. - this information is from GARD/ORDR/NCATS.

MSH Definition: A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)

Synonyms & Abbreviations: (see Synonym Details)
Atrophies, Lobar (Brain)
Atrophy, Lobar (Brain)
Brain Atrophy, Circumscribed Lobar
Circumscribed cerebral atrophy
Circumscribed Lobar Atrophy of the Brain
Dementia due to Pick's disease
Dementia in Pick's disease
Dementia with lobar atrophy and neuronal cytoplasmic inclusions
Disease, Pick's
Disease, Pick
Lobar Atrophies (Brain)
Lobar Atrophy (Brain)
Lobar Atrophy Of Brain
Lobar atrophy of the brain
PICK DIS OF THE BRAIN
Pick Disease Of Brain
Pick Disease of the Brain [Disease/Finding]
Pick disease of the brain
PICK DISEASE
PICK DIS
Pick's disease (disorder)
Pick's disease
PICKS DIS OF BRAIN
Picks Disease of Brain
Picks Disease
PICKS DIS

External Source Codes: 
NCI Thesaurus Code C85008 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CO DG DH DI DT EC EH EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH SU TH UR VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID F111. SNOMEDCT_US
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0485-6612 CSP
DISEASE_IDENTIFIER_ID 5406 GARD
DISEASE_IDENTIFIER_ID 5407 GARD
DISEASE_IDENTIFIER_ID 5408 GARD
DX 20000101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
GENELOCUS ,1,7,q,2,1,.,1, OMIM
GENESYMBOL DDPAC OMIM
GENESYMBOL MAPT OMIM
GENESYMBOL MSTD OMIM
GENESYMBOL MTBT1 OMIM
HAS_GARD_PAGE true GARD
HN 2000; for PICKS DISEASE OF BRAIN use DEMENTIA 1992-1999 MSH
IAN ASTERISK ICD10
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2009-12-30T00:00:00 GARD
MDA 19991105 MSH
MESH_DEFINITION A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9) NDFRT
MESH_DUI D020774 NDFRT
MESH_NAME Pick Disease of the Brain NDFRT
MESH_UI M0005800 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20150623 MSH
MN C10.228.140.380.266.299.500 MSH
MN F03.615.400.380.299.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000004183 NDFRT
ORDER_NO 05878 ICD10CM
PM 2000; for PICKS DISEASE OF BRAIN see DEMENTIA 1992-1999 MSH
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7392/picks-disease/resources/1 GARD
RXAUI 3118624 RXNORM
RXAUI 3133632 RXNORM
RXAUI 3189999 RXNORM
RXAUI 3220886 RXNORM
RXAUI 3220888 RXNORM
RXAUI 3220889 RXNORM
RXAUI 3220891 RXNORM
RXAUI 3220894 RXNORM
RXAUI 3287871 RXNORM
RXAUI 4222685 RXNORM
RXAUI 5039601 RXNORM
RXAUI 5039810 RXNORM
RXCUI 1022721 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.0 MDR
SMQ_TERM_LMVERSION 12.0 MDR
SMQ_TERM_LMVERSION 13.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_STATUS I MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 13092008 NDFRT
SOS Atrophy of frontal and temporal lobes from unknown causes. AOD
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G31.0 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G31.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G31.01 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ALTERED BEHAVIOR CO-OCCURRENT AND DUE TO PICK'S DISEASE CHOOSE F02.81 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 82351000119105 | Altered behavior co-occurrent and due to Pick's disease | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F02.81 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G31.01 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F111. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T010821 MSH
TERMUI T010822 MSH
TERMUI T369917 MSH
TERMUI T369918 MSH
TERMUI T369919 MSH
TERMUI T369920 MSH
TERMUI T369921 MSH
TERMUI T750418 MSH
TERMUI T781527 MSH
TERMUI T812127 MSH
TERMUI T812128 MSH
TH NLM (1992) MSH
TH NLM (2000) MSH
TH NLM (2010) MSH
TH NLM (2012) MSH
TH OMIM (2013) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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