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Exfoliation Syndrome (CUI C0206368) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0206368

NCI Thesaurus Code: C129025  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An autosomal dominant disorder caused by mutations in the LOXL1 gene, encoding lysyl oxidase homolog 1. The condition is characterized by abnormal fibrillar extracellular material in anterior segment tissues, and may lead to glaucoma.

MSH Definition: The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)

Synonyms & Abbreviations: (see Synonym Details)
Exfoliation glaucoma
Exfoliation Syndrome [Disease/Finding]
Exfoliation Syndromes
EXFOLIATION SYNDROME
Exfoliative Syndromes
Exfoliative Syndrome
GLAUCOMA CAPSULARE
PEXG
PEXS
Pseudo Exfoliation Syndrome
Pseudo-Exfoliation Syndromes
Pseudo-Exfoliation Syndrome
Pseudoexfoliat glaucoma
Pseudoexfoliation glaucoma (disorder)
Pseudoexfoliation glaucoma
Pseudoexfoliation Of The Lens
Pseudoexfoliation Syndromes
Pseudoexfoliation syndrome
Secondary open-angle glaucoma with pseudoexfoliation
Syndrome, Exfoliation
Syndrome, Exfoliative
Syndrome, Pseudo-Exfoliation
Syndrome, Pseudoexfoliation
Syndromes, Exfoliation
Syndromes, Exfoliative
Syndromes, Pseudo-Exfoliation
Syndromes, Pseudoexfoliation
XFG
XFS

External Source Codes: 
NCI Thesaurus Code C129025 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN shedding of pigment from the iris MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CTV3ID F4551 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19940101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D005902 MSH
GENELOCUS ,1,5,q,2,4,.,1, OMIM
GENESYMBOL LOXL1 OMIM
GENESYMBOL LOXL OMIM
HN 94 MSH
ICA Use additional code to identify glaucoma stage (365.70-365.74) ICD9CM
MDA 19930603 MSH
MESH_DEFINITION The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380) NDFRT
MESH_DUI D017889 NDFRT
MESH_NAME Exfoliation Syndrome NDFRT
MESH_UI M0027032 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN C11.941.375.285 MSH
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000003646 NDFRT
PM 94 MSH
PRIMARY_PATH 10074026$10018305$10018307$10015919$Exfoliation glaucoma$Glaucomas (excl congenital)$Glaucoma and ocular hypertension$Eye disorders MDR
PRIMARY_PATH 10074027$10002685$10002693$10015919$Exfoliation syndrome$Anterior chamber structural change, deposit and degeneration$Anterior eye structural change, deposit and degeneration$Eye disorders MDR
PRIMARY_SOC 10015919 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
RXAUI 3156208 RXNORM
RXAUI 3156209 RXNORM
RXAUI 3156213 RXNORM
RXAUI 3165510 RXNORM
RXAUI 3225686 RXNORM
RXAUI 3225736 RXNORM
RXAUI 5039332 RXNORM
RXAUI 5039868 RXNORM
RXCUI 1024800 RXNORM
SMQ_TERM_ADDVERSION 11.0 MDR
SMQ_TERM_ADDVERSION 15.1 MDR
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 11.0 MDR
SMQ_TERM_LMVERSION 16.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 111514006 NDFRT
SNOMEDID DA-73321 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS H40.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~H40.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS H40.1490 | CONSIDER LATERALITY SPECIFICATION | CONSIDER STAGE OF GLAUCOMA SPECIFICATION SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~H40.1490 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F4551 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-73321 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T053478 MSH
TERMUI T053479 MSH
TERMUI T053480 MSH
TERMUI T053481 MSH
TERMUI T053482 MSH
TERMUI T812100 MSH
TERMUI T812101 MSH
TH NLM (1994) MSH
TH OMIM (2013) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0206368

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