|Terms & Properties|
Concept Unique Identifier (CUI): C0206116
NCI Thesaurus Code: C12616 (see NCI Thesaurus info)
Semantic Type: Cell
NCIt Definition: A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis.
CSP Definition: small, mobile, phagocytic neuroglila of the CNS derived from mesodermal progenitor cells of the monocyte-macrophage type.
MSH Definition: The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Synonyms & Abbreviations: (see Synonym Details)
|Microglial cells set|
|perivascular glial cell|
|Set of microglial cells|
|small glial cell|
External Source Codes:
|NCI Thesaurus Code||C12616 (see NCI Thesaurus info)|
|AN||a type of neuroglia; A 11 qualif||MSH|
|AQL||CH CL CY DE EN IM ME MI PA PH PS RE SE TR UL VI||MSH|
|AUTHORITY||Gray's 99:938 fig.8.41;1414||FMA|
|AUTHORITY||Nomina Anatomica 1989||FMA|
|AUTHORITY||Unified Medical Language System||FMA|
|DATE_LAST_MODIFIED||Fri Jun 09 13:28:15 PDT 2000||FMA|
|SOS||Small cells of nonectodermal origin that form the third of the three major families of neuroglia in the central nervous system. Microglia are believed to be of mesodermal origin and may have several sources, such as circulating monocytes and perivascular pericytes. Following infection or damage to brain tissue, they become actively phagocytic (gitter cells), rounded with phagocytized material, and are usually carried away and destroyed.||AOD|
Additional Concept Data: (none)