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Microglia (CUI C0206116) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0206116

NCI Thesaurus Code: C12616  (see NCI Thesaurus info)

Semantic Type: Cell

NCIt Definition: A type of glial cell that mediates immune responses by clearing cellular debris and dead neurons from nervous tissue through phagocytosis.

CSP Definition: small, mobile, phagocytic neuroglila of the CNS derived from mesodermal progenitor cells of the monocyte-macrophage type.

MSH Definition: The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.

Synonyms & Abbreviations: (see Synonym Details)
gitter cell
Hortega cell
mesoglia
Microglial cells set
microglial cell
microglia
Microgliocyte (cell)
microgliocyte
perivascular glial cell
Set of microglial cells
small glial cell

External Source Codes: 
NCI Thesaurus Code C12616 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN a type of neuroglia; A 11 qualif MSH
AQL CH CL CY DE EN IM ME MI PA PH PS RE SE TR UL VI MSH
AUTHORITY Gray's 99:938 fig.8.41;1414 FMA
AUTHORITY Gray's 99:942 FMA
AUTHORITY Nomina Anatomica 1989 FMA
AUTHORITY Rosse MD FMA
AUTHORITY Unified Medical Language System FMA
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000227009 SNOMEDCT_US
Contributing_Source CTRP NCI
CTV3ID XUHyK SNOMEDCT_US
DATE_LAST_MODIFIED Fri Jun 09 13:28:15 PDT 2000 FMA
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2047-3495 CSP
DX 19940101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HN 94 MSH
MDA 19930618 MSH
MN A08.637.400 MSH
MN A11.650.400 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
PM 94 MSH
SOS Small cells of nonectodermal origin that form the third of the three major families of neuroglia in the central nervous system. Microglia are believed to be of mesodermal origin and may have several sources, such as circulating monocytes and perivascular pericytes. Following infection or damage to brain tissue, they become actively phagocytic (gitter cells), rounded with phagocytized material, and are usually carried away and destroyed. AOD
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUHyK SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T052818 MSH
TH NLM (1994) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UWT Anatomical Structure UWDA

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0206116

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