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| Terms & Properties |
Concept Unique Identifier (CUI): C0206085
NCI Thesaurus Code: C84800 (see NCI Thesaurus info)
Semantic Type: Disease or Syndrome
NCIt Definition: A rare disorder characterized by episodes of excessive sleep and behavioral alterations while awake. It affects predominantly males. The individuals exhibit normal behavior between episodes.
GARD Definition: Kleine Levin syndrome is a rare disorder characterized by episodes of excessive sleep. Affected individuals may sleep for up to 20 hours per day during an episode. These episodes usually last for a few days to a few weeks. An episode may start abruptly and is sometimes associated with flu-like symptoms. During an episode, people with Kleine Levin syndrome can also display abnormal behavior, such as excessive food intake, irritability, childishness, disorientation, hallucinations, and an abnormally uninhibited sex drive. Affected individuals do not experience any of these features between episodes, and they may not be able to remember everything that happened during an episode. The time between episodes varies among individuals with this condition. Kleine Levin syndrome primarily affects adolescent males, but it also affects females. It may be caused by abnormal function of the hypothalamus and thalamus, parts of the brain that control appetite and sleep. Episodes usually decrease in frequency and intensity after about eight to 12 years. - this information is from GARD/ORDR/NCATS.
MSH Definition: A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569)
Synonyms & Abbreviations: (see Synonym Details)
| Hibernation Syndrome, Kleine-Levin |
| Hypersomnia, Periodic |
| Hypersomnia-bulimia syndrome |
| Kleine Levin Critchley Syndrome |
| Kleine Levin Hibernation Syndrome |
| Kleine Levin syndrome |
| Kleine-Levin hibernation syndrome |
| Kleine-Levin syndrome (disorder) |
| Kleine-Levin Syndrome [Disease/Finding] |
| Kleine-Levin syndrome |
| Kleine-Levin-Critchley Syndrome |
| Periodic Hypersomnias |
| Periodic Hypersomnia |
| Syndrome, Kleine-Levin Hibernation |
| Syndrome, Kleine-Levin-Critchley |
| Syndrome, Kleine-Levin |
External Source Codes:
| NCI Thesaurus Code | C84800 (see NCI Thesaurus info) |
Other Properties:
| Name | Value | Source |
|---|---|---|
| ACTIVE | 1 | SNOMEDCT_US |
| AQL | BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI | MSH |
| CASE_SIGNIFICANCE_ID | 900000000000017005 | SNOMEDCT_US |
| CTV3ID | X008E | SNOMEDCT_US |
| DATE_CREATED | 2013-01-09T00:04:00 | GARD |
| DATE_CREATED | 2015-01-22T00:04:00 | GARD |
| DATE_LAST_MODIFIED | 2013-01-09T00:04:00 | GARD |
| DC | 1 | MSH |
| DEFINITION_STATUS_ID | 900000000000074008 | SNOMEDCT_US |
| DISEASE_IDENTIFIER_ID | 11167 | GARD |
| DISEASE_IDENTIFIER_ID | 32754 | GARD |
| DX | 19940101 | MSH |
| EFFECTIVE_TIME | 20020131 | SNOMEDCT_US |
| HAS_GARD_PAGE | true | GARD |
| HN | 94 | MSH |
| IDENTIFIER_SOURCE | Orp | GARD |
| IDENTIFIER_TYPE_ID | 1 | GARD |
| IS_ACTIVE | true | GARD |
| IS_RARE | true | GARD |
| IS_SPANISH | false | GARD |
| LAST_REVIEW_DATE | 2008-10-10T00:00:00 | GARD |
| MDA | 19921228 | MSH |
| MESH_DEFINITION | A rare condition characterized by recurrent hypersomnias associated with hyperphagia, occurring primarily in males in the second to third decade of life. Clinical features include mental confusion, excessive sleep requirements (approximately 18 hours per day), restlessness, and in some cases hallucinations. Episodes have a duration of days to weeks, and may recur several times per year. This condition may resolve spontaneously over several years. (From Adams, et al., Principles of Neurology, 6th ed, p569) | NDFRT |
| MESH_DUI | D017593 | NDFRT |
| MESH_NAME | Kleine-Levin Syndrome | NDFRT |
| MESH_UI | M0026659 | NDFRT |
| MIMTYPE | 5 | OMIM |
| MIMTYPEMEANING | Mendelian phenotype or locus, molecular basis unknown. | OMIM |
| MIMTYPEVALUE | perc | OMIM |
| MMR | 20120703 | MSH |
| MN | C10.886.425.800.200.500 | MSH |
| MN | F03.870.400.800.200.500 | MSH |
| NDFRT_KIND | DISEASE_KIND | NDFRT |
| NUI | N0000003612 | NDFRT |
| PM | 94 | MSH |
| PRIMARY_PATH | 10053712$10040993$10040991$10037175$Hypersomnia-bulimia syndrome$Sleep disorders NEC$Sleep disorders and disturbances$Psychiatric disorders | MDR |
| PRIMARY_SOC | 10037175 | MDR |
| PT_IN_VERSION | 10.0 | MDR |
| PT_IN_VERSION | 10.1 | MDR |
| PT_IN_VERSION | 11.0 | MDR |
| PT_IN_VERSION | 11.1 | MDR |
| PT_IN_VERSION | 12.0 | MDR |
| PT_IN_VERSION | 12.1 | MDR |
| PT_IN_VERSION | 13.0 | MDR |
| PT_IN_VERSION | 13.1 | MDR |
| PT_IN_VERSION | 14.0 | MDR |
| PT_IN_VERSION | 14.1 | MDR |
| PT_IN_VERSION | 15.0 | MDR |
| PT_IN_VERSION | 15.1 | MDR |
| PT_IN_VERSION | 16.0 | MDR |
| PT_IN_VERSION | 16.1 | MDR |
| PT_IN_VERSION | 17.0 | MDR |
| PT_IN_VERSION | 17.1 | MDR |
| PT_IN_VERSION | 18.0 | MDR |
| PT_IN_VERSION | 18.1 | MDR |
| PT_IN_VERSION | 19.0 | MDR |
| PT_IN_VERSION | 19.1 | MDR |
| PT_IN_VERSION | 20.0 | MDR |
| PT_IN_VERSION | 20.1 | MDR |
| PT_IN_VERSION | 8.0 | MDR |
| PT_IN_VERSION | 8.1 | MDR |
| PT_IN_VERSION | 9.0 | MDR |
| PT_IN_VERSION | 9.1 | MDR |
| RARE_DISEASE_URL | http://rarediseases.info.nih.gov/gard/3117/kleine-levin-syndrome/resources/1 | GARD |
| RXAUI | 3174541 | RXNORM |
| RXAUI | 3184942 | RXNORM |
| RXAUI | 3184943 | RXNORM |
| RXAUI | 3184944 | RXNORM |
| RXAUI | 3606001 | RXNORM |
| RXCUI | 987772 | RXNORM |
| SNOMED_CID | 111488004 | NDFRT |
| SUBSET_MEMBER | 447562003~CORRELATIONID~447561005 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPADVICE~ALWAYS G47.8 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPCATEGORYID~447637006 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPGROUP~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPPRIORITY~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPRULE~TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 447562003~MAPTARGET~G47.8 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~CORRELATIONID~447561005 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPADVICE~ALWAYS G47.13 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPCATEGORYID~447637006 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPGROUP~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPPRIORITY~1 | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPRULE~TRUE | SNOMEDCT_US |
| SUBSET_MEMBER | 6011000124106~MAPTARGET~G47.13 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000497000~MAPTARGET~X008E | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000508004~ACCEPTABILITYID~900000000000549004 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000548007 | SNOMEDCT_US |
| SUBSET_MEMBER | 900000000000509007~ACCEPTABILITYID~900000000000549004 | SNOMEDCT_US |
| TERMUI | T052754 | MSH |
| TERMUI | T052755 | MSH |
| TERMUI | T052756 | MSH |
| TERMUI | T769530 | MSH |
| TH | NLM (1994) | MSH |
| TH | NLM (2011) | MSH |
| TH | OMIM (2013) | MSH |
| TH | ORD (2010) | MSH |
| TYPE_ID | 900000000000003001 | SNOMEDCT_US |
| TYPE_ID | 900000000000013009 | SNOMEDCT_US |
Additional Concept Data: (none)
URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0206085
