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Nephrogenic Diabetes Insipidus (CUI C0162283) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0162283

NCI Thesaurus Code: C84919  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone.

MSH Definition: A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.

GARD Definition: Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. Nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (ADH) or vasopressin. ADH normally tells the kidneys to make the urine more concentrated. As a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.

Nephrogenic diabetes insipidus can be either acquired or hereditary. The acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. The hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life.
- this information is from GARD/ORDR/NCATS.

HPO Definition: A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP). [HPO:curators]

NICHD Definition: Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone (vasopressin), which is caused by mutation(s) in the AVPR2 gene, encoding the vasopressin V2 receptor (antidiuretic hormone receptor), or by mutation(s) in the AQP2 gene, encoding aquaporin-2. Inheritance may by X-linked (AVPR2) or autosomal dominant or recessive (AQP2).

CSP Definition: polyuric disorder characterized by normal rates of renal filtration and solute excretion, but a persistent hypotonic urine due to the failure of renal tubules to respond to antidiuretic hormones, such as vasopressin, to reduce urine volume; tubular insensitivity to vasopressin can result from genetic defects, diseases, drug effects, or may occur with pregnancy.

Synonyms & Abbreviations: (see Synonym Details)
ADH resistant diabetes insipidus
ADH-resistant diabetes insipidus
Adiuretin-resistant diabetes insipidus
DIABETES INSIPIDUS NEPHROGENIC
Diabetes Insipidus, Nephrogenic [Disease/Finding]
DIABETES INSIPIDUS, NEPHROGENIC
DIABETES INSIPIDUS, VASOPRESSIN-RESISTANT
NDI - Nephrogenic diabetes insipidus
NDI
Nephrogen diabetes insip
Nephrogenic diabetes insipidus (disorder)
Nephrogenic Diabetes Insipidus
Renal diabetes insipidus
vasopressin resistant diabetes insipidus
Vasopressin-resistant diabetes insipidus
Vasopressin-resistant hyposthenuria
Vasopressin-unresponsiveness hyposthenuria

External Source Codes: 
NCI Thesaurus Code C84919 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with DIABETIC NEPHROPATHIES which refers to diabetes mellitus or with DIABETES INSIPIDUS, NEUROGENIC MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID K081. SNOMEDCT_US
DATE_CREATED 2009-02-16T11:23:28Z HPO
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1849-2659 CSP
DISEASE_IDENTIFIER_ID 4577 GARD
DISEASE_IDENTIFIER_ID 4579 GARD
DISEASE_IDENTIFIER_ID 4580 GARD
DX 19950101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 diabetes insipidus NOS (E23.2) ICD10CM
FX D017483 MSH
FX D051399 MSH
HAS_GARD_PAGE true GARD
HN 95 MSH
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19940416 MSH
MESH_DEFINITION A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY. NDFRT
MESH_DUI D018500 NDFRT
MESH_NAME Diabetes Insipidus, Nephrogenic NDFRT
MESH_UI M0027741 NDFRT
MMR 20130708 MSH
MN C12.777.419.135.500 MSH
MN C13.351.968.419.135.500 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Nephrogenic Diabetes Insipidus NCI
NUI N0000003831 NDFRT
ORDER_NO 23361 ICD10CM
PM 95 MSH
PRIMARY_PATH 10029147$10029150$10029149$10038359$Nephrogenic diabetes insipidus$Nephropathies and tubular disorders NEC$Nephropathies$Renal and urinary disorders MDR
PRIMARY_SOC 10038359 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7178/nephrogenic-diabetes-insipidus/resources/1 GARD
RXAUI 3146285 RXNORM
RXAUI 3146286 RXNORM
RXAUI 3205591 RXNORM
RXCUI 1025854 RXNORM
SMQ_TERM_ADDVERSION 17.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 17.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 111395007 NDFRT
SOS Excludes: diabetes insipidus NOS (253.5) ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS N25.1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~N25.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS N25.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DRUG-INDUCED NEPHROGENIC DIABETES INSIPIDUS CHOOSE N25.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DRUG-INDUCED NEPHROGENIC DIABETES INSIPIDUS CHOOSE T50.905? | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | EPISODE OF CARE INFORMATION NEEDED | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF SCHOFER BEETZ BOHL SYNDROME CHOOSE G93.89 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 118951003 | Drug-induced nephrogenic diabetes insipidus | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 716200002 | Schofer Beetz Bohl syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G93.89 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~N25.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~T50.905? SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~K081. SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T055100 MSH
TERMUI T605421 MSH
TH GHR (2014) MSH
TH NLM (1995) MSH
TH NLM (2006) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0162283

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