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Neurofibrillary degeneration (morphologic abnormality) (CUI C0085400) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0085400

Semantic Type: Acquired Abnormality

HPO Definition: Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form. [HPO:sdoelken]

CSP Definition: intracellular knots or clumps of neurofibrils seen in various parts of the brain in Alzheimer's disease; composed of dense arrays of paired helical filaments (neurofilaments and microtubules) and incorporating the following proteins: intermediate filaments, medium and high molecular weight neurofilaments, microtubule associated proteins, map2 and tau, actin, and ubiquitins.

MSH Definition: Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease.

Synonyms & Abbreviations: (see Synonym Details)
Alzheimer's neurofibrillary change
Alzheimer's neurofibrillary degeneration
Argentophilic neuronal inclusion
Neurofibrillary degeneration (morphologic abnormality)
Neurofibrillary degeneration
Neurofibrillary tangles composed of disordered microtubules in neurons
Neurofibrillary tangles
neurofibrillary tangle
NFT
Paired helical filaments
Tangle, Neurofibrillary
Tangles, Neurofibrillary

External Source Codes:  (none)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN "one of the hallmarks of Alzheimer disease"; A 11 qualif except /cytol; /genet permitted MSH
AQL CH CL DE EN GE IM ME MI PA PH PS RE SE TR UL VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CTV3ID XUMQ9 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2042-3269 CSP
DX 19920101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D009454 MSH
FX D016900 MSH
FX D024801 MSH
FX D055956 MSH
HN 92 MSH
MDA 19910502 MSH
MMR 20140613 MSH
MN A08.675.609.520 MSH
MN A11.284.430.214.190.750.640.520 MSH
MN A11.671.573.520 MSH
PM 92 MSH
SID HP:0003132 HPO
SID HP:0007070 HPO
SMQ_TERM_ADDVERSION 18.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 18.1 MDR
SMQ_TERM_SCOPE 1 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUMQ9 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T050513 MSH
TH NLM (1992) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0085400

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