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Lithium Carbonate (CUI C0085217) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0085217

NCI Thesaurus Code: C1318  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Inorganic Chemical

NCIt Definition: The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.

PDQ Definition: The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells. Check for active clinical trials using this agent. (NCI Thesaurus)

MSH Definition: A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.

Synonyms & Abbreviations: (see Synonym Details)
Carbonate, Dilithium
Carbonate, Lithium
Carbonic acid, dilithium salt
Dilithium Carbonate
Escalith
Eskalith
Lithane
Lithium carbonate (product)
Lithium carbonate (substance)
Lithium Carbonate [Chemical/Ingredient]
Lithium carbonate preparation
Lithium carbonate
Lithium
Lithobid
Lithonate
Lithotabs

External Source Codes: 
NCI Thesaurus Code C1318 (see NCI Thesaurus info)
CAS Registry Number 554-13-2 (see NLM ChemIDplus info)
FDA UNII Code 2BMD2GNA4V
NSC Code 16895 (see NCI DTP info)
PDQ Closed Trial Search ID 39491
PDQ Open Trial Search ID 39491 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:6504 NCI
Chemical_Formula CO3.2Li NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID d61.. SNOMEDCT_US
CTV3ID XUWqp SNOMEDCT_US
DATE_LAST_MODIFIED 2008-02-15 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19920101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE 2BMD2GNA4V NDFRT
HN 92; was LITHIUM CARBONATE (NM) 1969-91 MSH
LEVEL Ingredient NDFRT
LEVEL Salts/Esters USPMG
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19910125 MSH
MESH_DEFINITION A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems. NDFRT
MESH_DUI D016651 NDFRT
MESH_NAME Lithium Carbonate NDFRT
MESH_UI M0025374 NDFRT
MMR 20150623 MSH
MN D01.045.125.500 MSH
MN D01.200.275.150.550 MSH
MN D01.510.475 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C1318 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006445 NDFRT
NUI N0000146351 NDFRT
OL use LITHIUM CARBONATE (NM) to search LITHIUM CARBONATE 1977-91 MSH
ORIG_STY Drug/agent PDQ
PA D000928 MSH
PA D004791 MSH
PA D018692 MSH
PID 2124 PDQ
PM 92; LITHIUM CARBONATE was indexed under LITHIUM 1969-91 MSH
RN 0 MSH
RN 2BMD2GNA4V MSH
RR 10377-37-4 (mono-Li salt) MSH
RR 554-13-2 (Lithium Carbonate) MSH
RXAUI 1137728 RXNORM
RXAUI 1140319 RXNORM
RXAUI 1140323 RXNORM
RXAUI 1140329 RXNORM
RXAUI 2072077 RXNORM
RXAUI 2599702 RXNORM
RXAUI 2605926 RXNORM
RXAUI 2719760 RXNORM
RXAUI 2990243 RXNORM
RXAUI 3130095 RXNORM
RXAUI 3147087 RXNORM
RXAUI 3187238 RXNORM
RXAUI 3187239 RXNORM
RXAUI 3189904 RXNORM
RXAUI 3189905 RXNORM
RXAUI 492575 RXNORM
RXAUI 5033481 RXNORM
RXCUI 203056 RXNORM
RXCUI 203320 RXNORM
RXCUI 203321 RXNORM
RXCUI 203322 RXNORM
RXCUI 203323 RXNORM
RXCUI 42351 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
RXN_OBSOLETED 09/30/2013 RXNORM
SNOMEDID C-15402 SNOMEDCT_US
SNOMEDID C-63C11 SNOMEDCT_US
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SPL_SET_ID fdc9c733-2a03-44f4-9df2-c1f520fd0ff1 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~d61.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWqp SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-15402 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-63C11 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T049861 MSH
TERMUI T049862 MSH
TERMUI T049863 MSH
TERMUI T049864 MSH
TERMUI T049865 MSH
TERMUI T049869 MSH
TERMUI T049871 MSH
TH FDA SRS (2014) MSH
TH NLM (1992) MSH
TH NLM (1996) MSH
TH USAN (1968) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^604^Active/Master NDFRT
VUID 4018007 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0085217

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