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Bupropion (CUI C0085208) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0085208

NCI Thesaurus Code: C62012  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: An aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine.

NCI-GLOSS Definition: A substance that is used to treat depression, and to help people quit smoking. It belongs to the family of drugs called antidepressants.

CSP Definition: unicyclic, aminoketone antidepressant; appears to block dopamine uptake; the hydrochloride is used as an aid to smoking cessation treatment.

MSH Definition: A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.

Synonyms & Abbreviations: (see Synonym Details)
(+-)-1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-1-propanone
1-Propanone, 1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-
amfebutamone
Amfebutamon
Bupropion (substance)
Bupropion [Chemical/Ingredient]
bupropion
Product containing bupropion (medicinal product)
Product containing bupropion

External Source Codes: 
NCI Thesaurus Code C62012 (see NCI Thesaurus info)
CAS Registry Number 34911-55-2 (see NLM ChemIDplus info)
FDA UNII Code 01ZG3TPX31

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN do not confuse with Zyban fungicide MSH
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3219 NCI
Chemical_Formula C13H18ClNO NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUOdn SNOMEDCT_US
CTV3ID XUWyR SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 4008-0018 CSP
DX 19920101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE 01ZG3TPX31 DRUGBANK
FDA_UNII_CODE 01ZG3TPX31 NDFRT
FX D016540 MSH
HN 92; was BUPROPION (NM) 1978-91 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19910124 MSH
MESH_DEFINITION A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. NDFRT
MESH_DUI D016642 NDFRT
MESH_NAME Bupropion NDFRT
MESH_UI M0025361 NDFRT
MMR 20160701 MSH
MN D02.522.818.110 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006417 NDFRT
NUI N0000147738 NDFRT
OL use BUPROPION (NM) to search BUPROPION 1980-91 MSH
PA D018687 MSH
PA D018765 MSH
PA D065690 MSH
PM 92; BUPROPION was indexed under PROPIOPHENONES 1978-91 MSH
RN 01ZG3TPX31 MSH
RR 31677-93-7 (HCl(+-)-isomer) MSH
RR 34841-36-6 (HCl) MSH
RR 34841-39-9 (Bupropion) MSH
RR 34911-55-2 ((+-)-isomer) MSH
RR ZG7E5POY8O MSH
RXAUI 2068710 RXNORM
RXAUI 3090800 RXNORM
RXAUI 3091486 RXNORM
RXAUI 3108080 RXNORM
RXAUI 3116086 RXNORM
RXAUI 3116087 RXNORM
RXAUI 3119358 RXNORM
RXAUI 3119361 RXNORM
RXAUI 3723646 RXNORM
RXAUI 492449 RXNORM
RXAUI 6395060 RXNORM
RXAUI 6395096 RXNORM
RXAUI 6396119 RXNORM
RXCUI 42347 RXNORM
SID APRD00621 DRUGBANK
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SPL_SET_ID d705cacb-5c5e-4f6a-becb-bace1a5a0a0b MTHSPL
SPL_SET_ID d7c0dfda-2e49-4a9e-8fbb-cc40217ccc28 MTHSPL
SPL_SET_ID d8aa531b-f0bf-4d3a-88a1-00838ec37f64 MTHSPL
SPL_SET_ID d9f2fa07-1447-499f-abee-ea4dc3ae0554 MTHSPL
SPL_SET_ID da0b194b-13ba-4437-9409-7c4aae80067e MTHSPL
SPL_SET_ID dbc0f86b-55e7-4667-a26e-47b948f608bd MTHSPL
SPL_SET_ID dee3f124-bc24-4a37-b2eb-501a66fef064 MTHSPL
SPL_SET_ID df777f28-cf31-4b73-b4ab-249479619566 MTHSPL
SPL_SET_ID df923448-4f81-47af-8e55-f7359746b05f MTHSPL
SPL_SET_ID e2eaf21d-0589-484e-9dba-82b3cd2299ac MTHSPL
SPL_SET_ID e3fb04de-2a55-456f-8ecc-ac44dc8e5b5a MTHSPL
SPL_SET_ID e43f5550-bdcb-49de-9b13-50b193ae4282 MTHSPL
SPL_SET_ID e4e38abf-ef67-405b-af2d-3d8e4533654d MTHSPL
SPL_SET_ID e537ed50-6677-45eb-9e62-af62d3831f19 MTHSPL
SPL_SET_ID e57451fd-aba5-47d6-9892-ffe2a6021b6f MTHSPL
SPL_SET_ID e962fb9a-d9fb-49c5-a8b4-0b355b8f829b MTHSPL
SPL_SET_ID e9cef726-267e-4e4f-ac12-d92a8664bf20 MTHSPL
SPL_SET_ID ecba926d-1ab6-4267-974f-bcea2f712043 MTHSPL
SPL_SET_ID ed2da3a6-0614-4bea-8e82-962cbaae6428 MTHSPL
SPL_SET_ID efae7a52-cd67-484c-a9b4-3edca3ec476e MTHSPL
SPL_SET_ID f0a4cdfd-0aa3-4dd9-ac5e-2d758d528b1f MTHSPL
SPL_SET_ID f0ace3e1-9823-41a0-9fd7-81979c840a65 MTHSPL
SPL_SET_ID f0c3cafa-8985-4dac-9be1-a92454a4ef6e MTHSPL
SPL_SET_ID f117f33d-b112-4ecc-a908-6ef3d2823294 MTHSPL
SPL_SET_ID f243483e-7b6f-4e6f-9584-73642008ece8 MTHSPL
SPL_SET_ID f2b2bbd5-720b-4871-9785-a60df6e2e00a MTHSPL
SPL_SET_ID f3b1c335-2562-4b10-b33e-e740fd633030 MTHSPL
SPL_SET_ID f4b8c21a-d5af-4520-b43e-cbc940072547 MTHSPL
SPL_SET_ID f676f4fc-7802-49c2-89de-513343105302 MTHSPL
SPL_SET_ID f7364c33-09f8-4113-8cdb-fb8f2aec71de MTHSPL
SPL_SET_ID f800ac11-136e-4f5c-a04f-b1c8d441433c MTHSPL
SPL_SET_ID f9166a47-71ee-4e0b-b0e5-045df043d908 MTHSPL
SPL_SET_ID f9378e0d-f502-4f8c-b953-713e4b36cf02 MTHSPL
SPL_SET_ID f972a548-aa1f-4031-ba54-3994eb441562 MTHSPL
SPL_SET_ID fb118c90-41b7-4bc9-a82f-a4a415faabbb MTHSPL
SPL_SET_ID fdd1fa5e-9dbf-4951-a8e9-33d06e05bdba MTHSPL
SPL_SET_ID fddc9630-2f9a-4104-888f-3714587d4fe7 MTHSPL
SPL_SET_ID fe3b3c55-c5d1-413f-a42e-2aaefcc2c029 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUOdn SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWyR SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T049827 MSH
TERMUI T049828 MSH
TERMUI T049829 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1992) MSH
TH NLM (1995) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2264^Active/Master NDFRT
VANDF_RECORD 50.6^2119^Active/Master NDFRT
VUID 4019645 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0085208

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