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Resveratrol (CUI C0073096) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0073096

NCI Thesaurus Code: C1215  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. (NCI05)

PDQ Definition: A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A substance found in the skins of grapes and in certain other plants, fruits, and seeds. It is made by various plants to help defend against invading fungi, stress, injury, infection, and too much sunlight. It is being studied in the prevention of cancer and heart disease. It is a type of antioxidant and a type of polyphenol.

Synonyms & Abbreviations: (see Synonym Details)
(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
3,4',5-stilbenetriol
3,5,4'-trihydroxystilbene
Resveratrol (substance)
resveratrol [Chemical/Ingredient]
resveratrol
RESV

External Source Codes: 
NCI Thesaurus Code C1215 (see NCI Thesaurus info)
CAS Registry Number 501-36-0 (see NLM ChemIDplus info)
FDA UNII Code Q369O8926L
NSC Code 327430 (see NCI DTP info)
PDQ Closed Trial Search ID 405819
PDQ Open Trial Search ID 405819 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CHEBI_ID CHEBI:27881 NCI
CHEBI_ID CHEBI:45713 NCI
Chemical_Formula C14H12O3 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUOgR SNOMEDCT_US
DATE_FIRST_PUBLISHED 2004-11-22 PDQ
DATE_LAST_MODIFIED 2008-10-13 PDQ
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE Q369O8926L NDFRT
FR 5724 MSH
HM D013267 MSH
HN Introduced 2000. AOD
II D010636 MSH
II D012264 MSH
II D014665 MSH
II D020533 MSH
LEVEL Ingredient NDFRT
MDA 19890613 MSH
MESH_DUI C059514 NDFRT
MESH_NAME resveratrol NDFRT
MESH_UI M0165532 NDFRT
MMR 20130531 MSH
NCI_THESAURUS_CODE C1215 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000176093 NDFRT
NUI N0000179228 NDFRT
ORIG_STY Drug/agent PDQ
PA D000894 MSH
PA D000972 MSH
PA D000975 MSH
PA D004791 MSH
PA D010975 MSH
PA D016587 MSH
PA D016588 MSH
RN Q369O8926L MSH
RR 501-36-0 (resveratrol) MSH
RXAUI 2655906 RXNORM
RXAUI 3227706 RXNORM
RXAUI 3227707 RXNORM
RXAUI 3262483 RXNORM
RXAUI 3262484 RXNORM
RXAUI 3283975 RXNORM
RXAUI 3546587 RXNORM
RXAUI 3546588 RXNORM
RXAUI 4236200 RXNORM
RXCUI 1000492 RXNORM
SC 1 MSH
SPL_SET_ID 041c1f97-d20d-4bb8-be66-5c2fefe8a720 MTHSPL
SPL_SET_ID 062fb73e-f927-4fa9-a474-daa58d3a266d MTHSPL
SPL_SET_ID 1bf5cf24-88eb-1ade-e054-00144ff8d46c MTHSPL
SPL_SET_ID 2acc9d1e-11c3-3848-e054-00144ff88e88 MTHSPL
SPL_SET_ID 3a2c0e7d-a9af-4d83-8339-280df9aa70f9 MTHSPL
SPL_SET_ID 4317c393-9b9f-478a-b505-2dee3b640eb7 MTHSPL
SPL_SET_ID 54ecfc52-8c81-422f-b3b1-5538ac3d9687 MTHSPL
SPL_SET_ID 64ad21f7-a65d-40af-8c5b-73e0a789f58d MTHSPL
SPL_SET_ID 6aa6ad3f-2c52-4031-9e6c-7526c42de71d MTHSPL
SPL_SET_ID 72d3b3d8-61bd-493d-8d63-807b60fccb3b MTHSPL
SPL_SET_ID 83c86e06-ca84-44b1-8a27-61f8ad8f7dd3 MTHSPL
SPL_SET_ID 8611fa93-56c8-4294-9af5-7b54ce7ef37c MTHSPL
SPL_SET_ID 86693adc-70f8-4a6a-8935-f2564971e78a MTHSPL
SPL_SET_ID 91cdadde-c7a0-4060-9457-4b116dbc79a3 MTHSPL
SPL_SET_ID 9cc3ac55-aec1-4f6b-8c44-6f0d84bfa2a2 MTHSPL
SPL_SET_ID a01122d9-2c61-482e-aa7d-b033d63126ea MTHSPL
SPL_SET_ID a29a0e6b-f9fd-48e3-8e33-7ead0133d5a4 MTHSPL
SPL_SET_ID af7de88b-4ed2-416c-bc60-cfc5e85f9477 MTHSPL
SPL_SET_ID b0a99964-d906-4c1d-8256-8c18dd9f88a6 MTHSPL
SPL_SET_ID b7e5132a-fcfd-4d51-996a-e75a2e8d767a MTHSPL
SPL_SET_ID b8eddaa8-3bd8-44d8-b210-9f00273cfccc MTHSPL
SPL_SET_ID d658fdc7-9dac-47bf-8e83-1433a29a6cf6 MTHSPL
SPL_SET_ID f24598c3-f060-43ff-91b8-bff634af77ac MTHSPL
SRC Pharmacol Res Commun 1988;20 Suppl 5:79 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUOgR SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T195535 MSH
TERMUI T195536 MSH
TERMUI T195537 MSH
TH FDA SRS (2013) MSH
TH NLM (1989) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^4454^Active/Master NDFRT
VANDF_RECORD 50.6^4240^Active/Master NDFRT
VUID 4026034 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0073096

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