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Modafinil (CUI C0066677) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0066677

NCI Thesaurus Code: C26661  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. (NCI04)

PDQ Definition: A synthetic central nervous system stimulant with wakefulness-promoting activity. Modafinil appears to inhibit dopamine reuptake, resulting in an increase in extracellular dopamine. This agent exhibits pronounced wakefulness-promoting activity (without sympathomimetic activity) and may improve cognitive function in certain clinical settings. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A drug that is being studied as a treatment for fatigue in patients with cancer. It belongs to the family of drugs called stimulants.

Synonyms & Abbreviations: (see Synonym Details)
2-((diphenylmethyl)sulfinyl)acetamide
Alertec
benzhydrylsulfinylacetamide
CEPA brand of modafinil
Cephalon brand of modafinil
Draxis brand of modafinil
Lafon brand of modafinil
Merckle brand of modafinil
Modafinil (substance)
modafinil [Chemical/Ingredient]
Modafinilo
Modafinilum
Modafinil
Moderateafinil
Modiodal
Nourypharma brand of modafinil
Product containing modafinil (medicinal product)
Product containing modafinil
Provigil
Vigil

External Source Codes: 
NCI Thesaurus Code C26661 (see NCI Thesaurus info)
CAS Registry Number 68693-11-8 (see NLM ChemIDplus info)
FDA UNII Code R3UK8X3U3D
PDQ Closed Trial Search ID 256449
PDQ Open Trial Search ID 256449 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Narcolepsy NCI
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C15H15NO2S NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID dz1.. SNOMEDCT_US
CTV3ID XUWpK SNOMEDCT_US
DATE_LAST_MODIFIED 2006-05-10 PDQ
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE R3UK8X3U3D DRUGBANK
FDA_UNII_CODE R3UK8X3U3D NDFRT
FR 1029 MSH
HM D001559 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19860813 MSH
MESH_DUI C048833 NDFRT
MESH_NAME modafinil NDFRT
MESH_UI M0140282 NDFRT
MMR 20141101 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C26661 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005978 NDFRT
NUI N0000148602 NDFRT
ORIG_STY Drug/agent PDQ
PA D064690 MSH
PA D065701 MSH
PID 11399 PDQ
RN R3UK8X3U3D MSH
RR 68693-11-8 (modafinil) MSH
RXAUI 1182466 RXNORM
RXAUI 2072392 RXNORM
RXAUI 2725004 RXNORM
RXAUI 3052102 RXNORM
RXAUI 3194883 RXNORM
RXAUI 3194884 RXNORM
RXAUI 3258774 RXNORM
RXAUI 3261369 RXNORM
RXAUI 3261370 RXNORM
RXAUI 438965 RXNORM
RXAUI 6342860 RXNORM
RXCUI 219484 RXNORM
RXCUI 30125 RXNORM
RXN_BN_CARDINALITY single RXNORM
SC 1 MSH
SID APRD00534 DRUGBANK
SOS metabolite of adrafinyl; armodafinil is the (R)-isomer MSH
SPL_SET_ID 01f6690c-1410-42ad-8eb3-e7df32eab3ba MTHSPL
SPL_SET_ID 0c634b7a-cce6-4c3d-9c49-63593755f49c MTHSPL
SPL_SET_ID 108a276f-b07b-d94f-4488-c3e3b6683d4f MTHSPL
SPL_SET_ID 120cd2f0-7021-4036-a4c3-2e06f0252d74 MTHSPL
SPL_SET_ID 1f89a085-c937-4e77-9e90-fb04536cb460 MTHSPL
SPL_SET_ID 299a585f-fed1-49f2-8750-657b1c5e0c70 MTHSPL
SPL_SET_ID 2b57c771-0041-4226-999c-7a788cf73552 MTHSPL
SPL_SET_ID 2cc86071-bc4b-446c-9b65-37b1ff43770f MTHSPL
SPL_SET_ID 3107e636-ad6f-4125-a90d-f16511b86f8d MTHSPL
SPL_SET_ID 3674f6e0-1e58-423f-aea6-9585e90977d7 MTHSPL
SPL_SET_ID 3bf643a3-ca5d-43bd-9b83-865fa5d4eb08 MTHSPL
SPL_SET_ID 4790bbe9-d753-1067-02ee-9536011650d9 MTHSPL
SPL_SET_ID 4b63aac6-4385-44a3-8390-cdbb0b4b5fe0 MTHSPL
SPL_SET_ID 5053c113-69df-4ade-a186-02bc054c23d1 MTHSPL
SPL_SET_ID 514d242d-48c9-4162-a85a-a433b41107ac MTHSPL
SPL_SET_ID 5bc33938-2717-471b-b066-c6c67317d4e0 MTHSPL
SPL_SET_ID 5e6fb6ac-ba3e-4002-9521-07193b7b8255 MTHSPL
SPL_SET_ID 6a8a2185-52f9-4952-a361-514e44b1cd44 MTHSPL
SPL_SET_ID 7207a87d-1bca-b7b5-6df2-605812b7c295 MTHSPL
SPL_SET_ID 8b79d52e-e6e5-4aaf-8835-242c72d6ee38 MTHSPL
SPL_SET_ID 91d2f78d-8501-45d8-b6ff-33b393f75079 MTHSPL
SPL_SET_ID 928a3ab6-b53c-4924-882c-9f2f49aba0f1 MTHSPL
SPL_SET_ID 944daf47-49a6-93ca-e348-4a0f1b6d937e MTHSPL
SPL_SET_ID 9f3b0bd2-72a3-411f-aeec-b533373f1a97 MTHSPL
SPL_SET_ID a85d5629-748d-4920-b0d6-3012a0ace1a3 MTHSPL
SPL_SET_ID ca740635-df30-46af-9202-55af9204f381 MTHSPL
SPL_SET_ID cad4201c-133c-4a61-9d93-3c5e51695430 MTHSPL
SPL_SET_ID e16c26ad-7bc2-d155-3a5d-da83ad6492c8 MTHSPL
SPL_SET_ID eba3a655-074b-46b3-88cf-3e6b2c0c8b15 MTHSPL
SPL_SET_ID f3b3097f-80b8-4410-af21-dcdea144e3c3 MTHSPL
SPL_SET_ID f51ca007-3955-4540-a88a-0ddae8d8e8ab MTHSPL
SPL_SET_ID fd75a8a7-a8ab-4141-9af9-989a220b9c19 MTHSPL
SRC Rev Electroencephalogr Neurophysiol Clin 1986;16(1):39 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~dz1.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWpK SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T170286 MSH
TERMUI T170287 MSH
TERMUI T462683 MSH
TERMUI T614611 MSH
TERMUI T614612 MSH
TERMUI T614613 MSH
TERMUI T614614 MSH
TERMUI T614615 MSH
TERMUI T614616 MSH
TERMUI T614617 MSH
TERMUI T614618 MSH
TERMUI T614619 MSH
TERMUI T840248 MSH
TH CA MSH
TH DE MSH
TH ES MSH
TH FR MSH
TH INN (19XX) MSH
TH NLM (1986) MSH
TH NLM (2004) MSH
TH NLM (2014) MSH
TH NL MSH
TH UK MSH
TH USAN (1986) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3821^Active/Master NDFRT
VANDF_RECORD 50.6^3549^Active/Master NDFRT
VUID 4021149 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0066677

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