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limonene (CUI C0064992) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0064992

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

PDQ Definition: An oral dietary supplement containing a natural cyclic monoterpene and major component of the oil extracted from citrus peels with potential chemopreventive and antitumor activities. Although the mechanism of action has yet to be fully elucidated, limonene and its metabolites perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol may inhibit tumor growth through inhibition of p21-dependent signaling and may induce apoptosis via the induction of the transforming growth factor beta-signaling pathway. In addition, they inhibit post-translational modification of signal transduction proteins, resulting in G1 cell cycle arrest as well as differential expression of cell cycle- and apoptosis-related genes. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonyms & Abbreviations: (see Synonym Details)
1-methyl-4-(1-methylethenyl)cyclohexene
1-methyl-4-prop-1-en-2-yl-cyclohexene
4-mentha-1,8-diene
4R)-1-methyl-4-prop-1-en-2-yl-cyclohexene
di-Limonene
Dipentene (limonene)
dipentene
Limonene (product)
Limonene (substance)
limonene [Chemical/Ingredient]
limonene, (+-)-isomer
limonene

External Source Codes:  (none)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID X79EZ SNOMEDCT_US
CTV3ID XUbiE SNOMEDCT_US
DATE_FIRST_PUBLISHED 2010-01-19 PDQ
DATE_LAST_MODIFIED 2010-09-20 PDQ
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040731 SNOMEDCT_US
FDA_UNII_CODE 9MC3I34447 NDFRT
FR 986 MSH
HM D013729 MSH
HM D053138 MSH
II D000894 MSH
II D002273 MSH
II D012997 MSH
II D016588 MSH
LEVEL Ingredient NDFRT
MDA 19690101 MSH
MESH_DUI C008281 NDFRT
MESH_NAME limonene NDFRT
MESH_UI M0051997 NDFRT
MMR 20140117 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000146762 NDFRT
NUI N0000179167 NDFRT
ORIG_STY Drug/agent PDQ
RN 9MC3I34447 MSH
RR 138-86-3 (limonene) MSH
RR 47MAJ1Y2NE MSH
RR 5989-54-8 ((S)-isomer) MSH
RR 7705-14-8 ((+-)-isomer) MSH
RR GFD7C86Q1W MSH
RXAUI 2070240 RXNORM
RXAUI 3091531 RXNORM
RXAUI 3093763 RXNORM
RXAUI 3141234 RXNORM
RXAUI 3141235 RXNORM
RXAUI 3260120 RXNORM
RXAUI 3261129 RXNORM
RXAUI 3261130 RXNORM
RXAUI 3261131 RXNORM
RXAUI 433243 RXNORM
RXCUI 28730 RXNORM
RXN_ACTIVATED 01/28/2010 RXNORM
RXN_OBSOLETED 08/30/2007 RXNORM
SC 1 MSH
SOS colorless liquid with a citrus-like odor; found in large number of oils; the most common terpene and is produced by hundreds of plants; dissolving agent for gall stones & gutta-percha; used in surfactant as a penetration enhancer; structure MSH
SRC Digest Dis 21(11):926;1976 MSH
SRC Food Cosmet Toxicol 12(5-6):703;1974 MSH
SRC J Med Entomol 11(5):617;1974 MSH
SRC Life Sci 19:1559;1976 MSH
SRC Xenobiot 5(1):33;1975 MSH
SRC Xenobiot 6(6):377;1976 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~X79EZ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUbiE SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T081996 MSH
TERMUI T081997 MSH
TERMUI T081999 MSH
TERMUI T082000 MSH
TERMUI T340233 MSH
TH FDA SRS (2013) MSH
TH NLM (1969) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1034^Active/Master NDFRT
VUID 4018436 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0064992

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