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Fluorescein (CUI C0060520) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0060520

NCI Thesaurus Code: C61766  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Indicator, Reagent, or Diagnostic Aid

NCIt Definition: An organic compound that has wide use as a synthetic coloring agent. It is prepared by heating phthalic anhydride and resorcinol over a zinc catalyst, and it crystallizes as a deep red powder. This agent emits an intense green fluorescence in the presence of alkaline solutions and therefore is used as a label when conjugated to antibodies or as a contrast agent for ophthalmic angiography.

MSH Definition: A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.

CSP Definition: phthalic yellow-green dye used as an indicator and diagnostic aid; used therapeutically as a diagnostic aid in corneal injuries and corneal trauma; also used to label antibodies for fluorescence.

Synonyms & Abbreviations: (see Synonym Details)
3',6'-dihydroxyfluoran
3,6-fluorandiol
9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone
9-(o-carboxyphenyl)-6-hydroxy-3H-xanthen-3-one
C.I. Solvent Yellow 94
Fluorescein [Chemical/Ingredient]
Fluorescein acid
Fluorescein stain (substance)
Fluorescein stain
Fluoresceine
fluorescein
Fluoreszein
Japan Yellow 201
Product containing fluorescein (medicinal product)
Product containing fluorescein
Resorcinolphthalein
Solvent Yellow 94
Yellow fluorescein

External Source Codes: 
NCI Thesaurus Code C61766 (see NCI Thesaurus info)
CAS Registry Number 2321-07-5 (see NLM ChemIDplus info)
FDA UNII Code TPY09G7XIR

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AD AE AN CH CL CS CT EC HI IP ME PD PK PO RE SD ST TO TU MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:31624 NCI
Chemical_Formula C20H12O5 NCI
Contributing_Source FDA NCI
CTV3ID x01Ga SNOMEDCT_US
CTV3ID X79Cb SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0396-3486 CSP
DX 19980101 MSH
EC analogs & derivatives:Fluoresceins MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE TPY09G7XIR DRUGBANK
FDA_UNII_CODE TPY09G7XIR NDFRT
HN 98; see FLUORESCEIN (NM) 1981-97 MSH
LEVEL Ingredient NDFRT
MDA 19970702 MSH
MESH_DEFINITION A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor. NDFRT
MESH_DUI D019793 NDFRT
MESH_NAME Fluorescein NDFRT
MESH_UI M0029368 NDFRT
MMR 20160531 MSH
MN D02.455.426.779.347.390 MSH
MN D03.633.300.953.275.390 MSH
MN D04.711.347.390 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006902 NDFRT
NUI N0000147851 NDFRT
PA D003287 MSH
PA D005456 MSH
PM 98; see FLUORESCEINS 1969-97 MSH
RN TPY09G7XIR MSH
RR 13182-27-9 (mono-Na salt) MSH
RR 2321-07-5 MSH
RR 518-47-8 (di-Na salt) MSH
RR 6417-85-2 (di-K salt) MSH
RR 93X55PE38X MSH
RXAUI 2071005 RXNORM
RXAUI 3158091 RXNORM
RXAUI 3158092 RXNORM
RXAUI 3160991 RXNORM
RXAUI 3160995 RXNORM
RXAUI 416128 RXNORM
RXAUI 6395387 RXNORM
RXAUI 6395413 RXNORM
RXAUI 6396245 RXNORM
RXCUI 25138 RXNORM
RXN_ACTIVATED 01/28/2010 RXNORM
RXN_OBSOLETED 12/04/2009 RXNORM
SID APRD00979 DRUGBANK
SID DB07777 DRUGBANK
SID EXPT01447 DRUGBANK
SPL_SET_ID 04866053-f973-471e-b3bc-241fb76303a2 MTHSPL
SPL_SET_ID 1c5a620f-7083-4fee-99e2-c9380541c368 MTHSPL
SPL_SET_ID 36009e1e-4b69-4cb0-bd3a-3c6115c1fcf9 MTHSPL
SPL_SET_ID 71a652d5-ba61-4f0e-8f62-1dc2b8d3b231 MTHSPL
SPL_SET_ID 7ddca6b6-ce58-4c05-a71b-b7c62519ab95 MTHSPL
SPL_SET_ID 88ced9b3-60af-492b-9aca-1046efed17cb MTHSPL
SPL_SET_ID 900ec4c1-e5e3-e940-5b02-cf2589955e20 MTHSPL
SPL_SET_ID a1823be3-a739-48bc-a3ea-ceb7cc5105ce MTHSPL
SPL_SET_ID b297d7a1-2fc4-4e4f-9821-2a1985b61ae0 MTHSPL
SPL_SET_ID b8cd0372-88f4-4f21-8991-3fec828537ef MTHSPL
SPL_SET_ID d06a4432-c76c-4e2a-abec-6bc5b4e82d51 MTHSPL
SPL_SET_ID dae037ad-dcb8-42e6-8996-e575922d7631 MTHSPL
SPL_SET_ID ebb3883c-71f6-4fd0-a7e6-0ba8e1136dd9 MTHSPL
SPL_SET_ID f5dbf66b-068d-4408-989b-4f29b3c48738 MTHSPL
SPL_SET_ID f72b68c7-a52f-40df-a47d-8e2d8174091d MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01Ga SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X79Cb SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T058856 MSH
TH BAN (19XX) MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH JAN (19XX) MSH
TH NLM (1998) MSH
TH USAN (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2380^Active/Master NDFRT
VANDF_RECORD 50.6^897^Active/Master NDFRT
VUID 4019760 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0060520

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