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Cefdinir (CUI C0060405) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0060405

NCI Thesaurus Code: C28914  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefdinir inhibits bacterial septum and cell wall synthesis formation.

Synonyms & Abbreviations: (see Synonym Details)
(6R,7R)-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R,Z)-7-(2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-(2 (2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid
Cefdinir (substance)
cefdinir [Chemical/Ingredient]
Cefdinirum
Cefdinir
CFDN
Product containing cefdinir (medicinal product)
Product containing cefdinir

External Source Codes: 
NCI Thesaurus Code C28914 (see NCI Thesaurus info)
CAS Registry Number 91832-40-5 (see NLM ChemIDplus info)
FDA UNII Code CI0FAO63WC

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3485 NCI
Chemical_Formula C14H13N5O5S2 NCI
Contributing_Source FDA NCI
CTV3ID XU2BM SNOMEDCT_US
CTV3ID XUUWG SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE CI0FAO63WC DRUGBANK
FDA_UNII_CODE CI0FAO63WC NDFRT
FR 228 MSH
HM D002511 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19880914 MSH
MESH_DUI C056814 NDFRT
MESH_NAME cefdinir NDFRT
MESH_UI M0159248 NDFRT
MMR 20141103 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000004492 NDFRT
NUI N0000148556 NDFRT
PA D000900 MSH
RN CI0FAO63WC MSH
RR 91832-40-5 MSH
RXAUI 2981243 RXNORM
RXAUI 3094526 RXNORM
RXAUI 3122585 RXNORM
RXAUI 3122586 RXNORM
RXAUI 3123482 RXNORM
RXAUI 3259680 RXNORM
RXAUI 3259681 RXNORM
RXAUI 415760 RXNORM
RXAUI 415765 RXNORM
RXCUI 25037 RXNORM
SC 1 MSH
SID APRD00644 DRUGBANK
SOS synthetic antibiotic; structure in first source MSH
SPL_SET_ID 06fbdb63-d32f-4212-9962-f1de15597dda MTHSPL
SPL_SET_ID 1165564d-025e-460d-a1bd-1ca5300ae3fe MTHSPL
SPL_SET_ID 1181a59e-a433-20d0-e054-00144ff88e88 MTHSPL
SPL_SET_ID 11a8f19e-a6f6-4fb9-9565-98fa78cb6304 MTHSPL
SPL_SET_ID 11c56998-b4d4-48d9-99b0-ecaeba7ec54c MTHSPL
SPL_SET_ID 145e4a41-286e-4033-97c4-92d674d7bb89 MTHSPL
SPL_SET_ID 2c3705f2-0b44-4d38-a7f9-4b392d0a1a45 MTHSPL
SPL_SET_ID 38f6adf7-e26c-4764-8ec9-360813874dd4 MTHSPL
SPL_SET_ID 417d5645-ea57-4a07-a21d-31a7132721cd MTHSPL
SPL_SET_ID 542fb9ea-f289-43c3-81fa-555a632e6a45 MTHSPL
SPL_SET_ID 54cbdd39-8ae6-4618-b417-de03db410476 MTHSPL
SPL_SET_ID 57f258ef-59c0-432c-a843-1e4375762f63 MTHSPL
SPL_SET_ID 5fb3c464-ab1a-4e2f-ba7a-9aa59b94ca00 MTHSPL
SPL_SET_ID 6f76b0f7-2b50-4d14-8bec-010597ae2880 MTHSPL
SPL_SET_ID 7216bbce-8e20-4b2e-af56-e520e0d5d2c7 MTHSPL
SPL_SET_ID 7490df67-56c0-4a1c-8533-2107f3e8aea5 MTHSPL
SPL_SET_ID 77e061e8-d3e2-4955-9f65-59510b5afc70 MTHSPL
SPL_SET_ID 7d3c6011-db72-40bb-bb66-bf04f3ec7119 MTHSPL
SPL_SET_ID 831f04e4-4566-49f8-9552-2378307a10c8 MTHSPL
SPL_SET_ID 8640931e-317a-42b4-806a-146f00ddf2a6 MTHSPL
SPL_SET_ID a056eb8b-04e8-42fb-a4ff-42f017a113cb MTHSPL
SPL_SET_ID a1f49fe1-b511-4f6b-a912-8ae8662d95a5 MTHSPL
SPL_SET_ID a3262279-1f9e-401b-9b02-6da3ef374b46 MTHSPL
SPL_SET_ID a4587ea9-c06b-4603-beea-1ef926a4d0be MTHSPL
SPL_SET_ID a5594006-8e37-459e-8e85-7e2a83d7a57e MTHSPL
SPL_SET_ID a78a68a4-5425-43c4-81cc-7733b72445b8 MTHSPL
SPL_SET_ID a84712bf-221d-4366-9cf0-b8c19428c276 MTHSPL
SPL_SET_ID a9c339ac-14a5-465e-a4fe-1d361d017ccf MTHSPL
SPL_SET_ID bcf04f49-8d0b-4563-9d0f-93939cdf6a6c MTHSPL
SPL_SET_ID befe82b9-e822-4917-9774-b4cbd0c66a1e MTHSPL
SPL_SET_ID c2d25379-bec7-4583-a8bc-8c03cdb893ed MTHSPL
SPL_SET_ID c2e19cf4-d7cf-4adc-86de-0bc0144af88d MTHSPL
SPL_SET_ID c36c0d83-583b-4448-97a3-00169fcbdf75 MTHSPL
SPL_SET_ID c3ca8720-8e27-47ed-9829-a42ae9eb885d MTHSPL
SPL_SET_ID cb7366ce-1778-451f-aba5-65cf73c9b87a MTHSPL
SPL_SET_ID d4fd4773-1bd8-48b0-b749-3f83d1ed25d0 MTHSPL
SPL_SET_ID d9243be5-bd27-4f37-ba8b-9f6f55f8b3e4 MTHSPL
SPL_SET_ID de3441e3-7fd2-4d29-a8b7-0f9b66e35c9c MTHSPL
SPL_SET_ID df26edb0-9bd6-449c-a187-0be0c9e2600c MTHSPL
SPL_SET_ID e49b6477-4c64-41a5-b3a3-37461757a6fd MTHSPL
SPL_SET_ID eb3b3440-95f4-450a-af9c-a87aca480bad MTHSPL
SPL_SET_ID ee96536a-cd94-45aa-a5bb-60425b557be7 MTHSPL
SPL_SET_ID f22acd90-5dc4-406d-af78-5f9c3a674647 MTHSPL
SPL_SET_ID f910ec1a-3896-45b9-b8b2-df50a50064a1 MTHSPL
SRC J Antibiot (Tokyo) 1988;41(6):828 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU2BM SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUUWG SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T189244 MSH
TERMUI T189245 MSH
TERMUI T189253 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (1988) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3768^Active/Master NDFRT
VANDF_RECORD 50.6^3492^Active/Master NDFRT
VUID 4021100 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0060405

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