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coenzyme Q10 (CUI C0056077) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0056077

NCI Thesaurus Code: C916  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

Semantic Type: Biologically Active Substance

NCIt Definition: A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04)

PDQ Definition: A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme-Q functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme-Q may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A nutrient that the body needs in small amounts to function and stay healthy. Coenzyme Q10 helps mitochondria (small structures in the cell) make energy. It is an antioxidant that helps prevent cell damage caused by free radicals (highly reactive chemicals). Coenzyme Q10 is fat-soluble (can dissolve in fats and oils) and is found in fatty fish, beef, soybeans, peanuts, and spinach. It is being studied in the prevention and treatment of some types of cancer and heart disease and in the relief of side effects caused by some cancer treatments.

CSP Definition: family of isoprenoid quinones which serve as mitochondrial electron transport cofactors.

MSH Definition: A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.

Synonyms & Abbreviations: (see Synonym Details)
140865
2,3-dimethoxy-5-methyl-6-decaprenylbenzoquinone
2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecanyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
303-98-0
Bio-Quinone Q10
co-enzyme Q10
Co-Q10
Coenzyme Q10 (product)
Coenzyme Q10 (substance)
coenzyme Q10 [Chemical/Ingredient]
Coenzyme Q10
coenzyme Q
coenzyme-Q10
coenzyme-Q
CoQ 10
CoQ10
Q10
Ubidecarenone
Ubiquinone 10
ubiquinone 50
Ubiquinone [Chemical/Ingredient]
ubiquinone Q10
ubiquinones
ubiquinone
vitamin Q10

External Source Codes: 
NCI Thesaurus Code C916 (see NCI Thesaurus info)
CAS Registry Number 303-98-0 (see NLM ChemIDplus info)
FDA UNII Code EJ27X76M46
NSC Code 140865 (see NCI DTP info)
PDQ Closed Trial Search ID 39187
PDQ Open Trial Search ID 39187 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Chronic heart failure; mitochondrial cytopathies NCI
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AI AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UL UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:46245 NCI
Chemical_Formula C59H90O4 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XUbwb SNOMEDCT_US
CTV3ID XUbwc SNOMEDCT_US
DATE_LAST_MODIFIED 2006-07-31 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2532-4451 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20040731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE EJ27X76M46 NDFRT
FR 2385 MSH
HM D014451/Q000031 MSH
II D019161/Q000031 MSH
II D045222/Q000031 MSH
LEVEL Ingredient NDFRT
MDA 19800715 MSH
MDA 19990101 MSH
MESH_DEFINITION A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals. NDFRT
MESH_DUI C024989 NDFRT
MESH_DUI D014451 NDFRT
MESH_NAME coenzyme Q10 NDFRT
MESH_NAME Ubiquinone NDFRT
MESH_UI M0022211 NDFRT
MESH_UI M0083834 NDFRT
MMR 20070709 MSH
MMR 20141103 MSH
MN D02.806.250.900 MSH
MN D08.211.935 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C916 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000010094 NDFRT
NUI N0000011446 NDFRT
NUI N0000148739 NDFRT
ORIG_STY Drug/agent PDQ
PA D014815 MSH
PA D018977 MSH
PI *COENZYMES (1980-2008) MSH
PID 1806 PDQ
RN 1339-63-5 MSH
RN EJ27X76M46 MSH
RR 27696-12-4 MSH
RR 303-98-0 MSH
RR 40819-90-7 MSH
RXAUI 1856625 RXNORM
RXAUI 1860578 RXNORM
RXAUI 1860582 RXNORM
RXAUI 3092231 RXNORM
RXAUI 3117731 RXNORM
RXAUI 3127267 RXNORM
RXAUI 3127268 RXNORM
RXAUI 3134049 RXNORM
RXAUI 3134050 RXNORM
RXAUI 3134252 RXNORM
RXAUI 3252373 RXNORM
RXAUI 3252376 RXNORM
RXAUI 3259829 RXNORM
RXAUI 3259830 RXNORM
RXAUI 3263130 RXNORM
RXAUI 3263131 RXNORM
RXAUI 3263132 RXNORM
RXAUI 3548984 RXNORM
RXAUI 4239651 RXNORM
RXAUI 4241382 RXNORM
RXAUI 7243782 RXNORM
RXCUI 10975 RXNORM
RXCUI 21406 RXNORM
SC 1 MSH
SOS Ubiquinone ring with a chain of 10 isoprene units; redox equilibrium with ubiqunol serving in mitochondrial inner membrane to transfer electrons; presence during reconstitution of acetylcholine receptor into phospholipid vesicles yields vesicles active in catalyzing carbamylcholine-sensitive Na+ flux; RN refers to (all-E)-isomer; coenzyme Q10 depletion has been noted with use of statins MSH
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SPL_SET_ID e83b2dd3-a9a0-40bc-ade4-6cd4db433b06 MTHSPL
SPL_SET_ID e891d868-be87-4f70-8a2c-79c2b611917d MTHSPL
SPL_SET_ID e9861169-c6b2-41e2-a0d3-0fcf8794a4e6 MTHSPL
SPL_SET_ID ea25e869-c8e5-4b74-8de5-9ee2ca663f6b MTHSPL
SPL_SET_ID eb4e343b-dbc8-43d3-93aa-042869de090c MTHSPL
SPL_SET_ID ebb8e3e4-db9d-484a-927c-e38b05e6e35f MTHSPL
SPL_SET_ID ece189a4-cc3e-44a7-8ec5-923d833c2488 MTHSPL
SPL_SET_ID ed382263-5346-4c0e-a652-3d9ed41d41cb MTHSPL
SPL_SET_ID ee3c1801-87e2-44a9-b55d-91f5ecfd7e9d MTHSPL
SPL_SET_ID eea6de39-1c18-4935-86e9-d7e4252eaec7 MTHSPL
SPL_SET_ID eef16915-e2cf-4483-9b99-9efcf012904a MTHSPL
SPL_SET_ID ef35e299-f244-4ff8-be75-6362290a4251 MTHSPL
SPL_SET_ID ef4d54bf-25f5-4261-9d3d-c42b0d892275 MTHSPL
SPL_SET_ID efdd0974-61bf-454c-9104-58156e80181a MTHSPL
SPL_SET_ID eff7e264-97f0-4a27-866e-7bfff3071da7 MTHSPL
SPL_SET_ID f0c53be7-01ac-40ed-b3cd-8911ba704346 MTHSPL
SPL_SET_ID f208dd0c-721a-4bf6-a725-b55e0817735d MTHSPL
SPL_SET_ID f26ecaab-d3fc-47de-a0ef-b0a3f0f4f71f MTHSPL
SPL_SET_ID f4923279-ebae-4565-88d7-5423945aac0f MTHSPL
SPL_SET_ID f5d78335-b78d-4909-a88b-9daa3c18ba15 MTHSPL
SPL_SET_ID f710269b-f1e2-4c43-9a31-7b67bdaf1254 MTHSPL
SPL_SET_ID f9cb3088-02fe-4dee-8e12-b9deb60d6460 MTHSPL
SPL_SET_ID faa803e6-453c-4d86-85dd-5a5dcdd72d02 MTHSPL
SPL_SET_ID fb1693cb-c2c3-4c8d-8394-03601c67867a MTHSPL
SPL_SET_ID fd5e45ae-403f-44a2-abc0-343b9f550bdf MTHSPL
SPL_SET_ID fd6d7db6-ccbd-4e4c-bee4-0a4777b476e2 MTHSPL
SPL_SET_ID fecb9fca-9a24-4c47-85ca-6e028f3c2c3d MTHSPL
SRC Biochem Biophys Res Commun 1980;93(2):409 MSH
SRC Biochim Biophys Acta 462:501;1977 MSH
SRC Biokhimiia 1979;44(10):1884 MSH
SRC J Biol Chem 1980;255(8):3278 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUbwb SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUbwc SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T042277 MSH
TERMUI T042278 MSH
TERMUI T113829 MSH
TERMUI T113830 MSH
TERMUI T113831 MSH
TERMUI T113832 MSH
TERMUI T113833 MSH
TERMUI T113834 MSH
TERMUI T113837 MSH
TERMUI T748255 MSH
TERMUI T856282 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TH NLM (1980) MSH
TH NLM (2009) MSH
TH NLM (2015) MSH
TH UNK (19XX) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3975^Active/Master NDFRT
VANDF_RECORD 50.6^3765^Active/Master NDFRT
VUID 4021303 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0056077

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