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Ceftibuten (CUI C0055014) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0055014

NCI Thesaurus Code: C61666  (see NCI Thesaurus info)

Semantic Type: Antibiotic

Semantic Type: Organic Chemical

NCIt Definition: A semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Synonyms & Abbreviations: (see Synonym Details)
(+)-(6R,7R)-7-((Z)-2-(2-amino-4-Thiazolyl)-4-carboxycrotonamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
7-(2-(2-amino-4-thiazolyl)-4-carboxy-2-butenoylamino)-3-cephem-4-carboxylic acid
Ceftibuten (substance)
ceftibuten [Chemical/Ingredient]
Ceftibutene
Ceftibuteno
Ceftibutenum
Ceftibuten
cis-Ceftibuten
Product containing ceftibuten (medicinal product)
Product containing ceftibuten

External Source Codes: 
NCI Thesaurus Code C61666 (see NCI Thesaurus info)
CAS Registry Number 97519-39-6 (see NLM ChemIDplus info)
FDA UNII Code IW71N46B4Y

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:3510 NCI
Chemical_Formula C15H14N4O6S2 NCI
Contributing_Source FDA NCI
CTV3ID e6n.. SNOMEDCT_US
CTV3ID XUWxy SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE IW71N46B4Y DRUGBANK
FDA_UNII_CODE IW71N46B4Y NDFRT
FR 205 MSH
HM D002511 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19880120 MSH
MESH_DUI C054360 NDFRT
MESH_NAME ceftibuten NDFRT
MESH_UI M0153553 NDFRT
MMR 20061215 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000004503 NDFRT
NUI N0000148426 NDFRT
PA D000900 MSH
PI *ANTIBIOTICS, LACTAM (88-89) MSH
RN 97519-39-6 MSH
RXAUI 3094527 RXNORM
RXAUI 3122862 RXNORM
RXAUI 3122863 RXNORM
RXAUI 3259695 RXNORM
RXAUI 3259696 RXNORM
RXAUI 396807 RXNORM
RXAUI 396816 RXNORM
RXAUI 6395127 RXNORM
RXAUI 6395193 RXNORM
RXCUI 20492 RXNORM
SC 1 MSH
SOS synthetic antibiotic; structure given in first source MSH
SPL_SET_ID 13229b1a-c1db-4303-8e73-f83fa1e5677c MTHSPL
SPL_SET_ID 2dd58c88-142f-41ad-bc31-0a4fff074970 MTHSPL
SPL_SET_ID 756d627b-021d-4609-aa08-af6cab80a812 MTHSPL
SRC J Antibiot (Tokyo) 1987;40(10):1468 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~e6n.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWxy SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T183550 MSH
TERMUI T183558 MSH
TH NLM (1988) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3608^Active/Master NDFRT
VANDF_RECORD 50.6^3313^Active/Master NDFRT
VUID 4020946 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0055014

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