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Azelaic Acid (CUI C0052761) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0052761

NCI Thesaurus Code: C47407  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A naturally occurring dicarboxylic acid produced by Malassezia furfur and found in whole grain cereals, rye, barley and animal products. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. This drug is used topically to reduce inflammation associated with acne and rosacea.

Synonyms & Abbreviations: (see Synonym Details)
1,7-Dicarboxyheptane
1,7-Heptanedicarboxylic acid
1,9-Nonanedioic acid
Acide azélaïque
Acidum acelaicum
Acidum azelaicum
Anchoic acid
Azelaic acid (product)
Azelaic acid (substance)
azelaic acid [Chemical/Ingredient]
Azelaic acid
Azelainsaeure
Azelainsäure
Azelex
Finacea
Heptanedicarboxylic Acid
Lepargylic acid
N-Nonanedioic acid
Nonandisaeure
Nonandisäure
Nonanedioic acid
ZK 62498
Ácido azelaico

External Source Codes: 
NCI Thesaurus Code C47407 (see NCI Thesaurus info)
CAS Registry Number 123-99-9 (see NLM ChemIDplus info)
FDA UNII Code F2VW3D43YT
NSC Code 19493 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:48131 NCI
Chemical_Formula C9H16O4 NCI
Contributing_Source FDA NCI
CTV3ID m6A.. SNOMEDCT_US
CTV3ID XUWoE SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE F2VW3D43YT DRUGBANK
FDA_UNII_CODE F2VW3D43YT NDFRT
FR 326 MSH
HM D003998 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
MDA 19690101 MSH
MESH_DUI C010038 NDFRT
MESH_NAME azelaic acid NDFRT
MESH_UI M0055275 NDFRT
MMR 20141031 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006287 NDFRT
NUI N0000148416 NDFRT
PA D000970 MSH
PA D003879 MSH
RN F2VW3D43YT MSH
RR 0P4H8NH3UJ MSH
RR 123-99-9 MSH
RR 17265-13-3 (di-Na salt) MSH
RR 17356-30-8 (mono-Na salt) MSH
RR 19619-43-3 (unspecified K salt) MSH
RR 27825-99-6 (unspecified Na salt) MSH
RR 38900-29-7 (di-Li salt) MSH
RR 52457-54-2 (di-K salt) MSH
RR C98170693J MSH
RXAUI 1175217 RXNORM
RXAUI 1551731 RXNORM
RXAUI 2068012 RXNORM
RXAUI 2622202 RXNORM
RXAUI 3104186 RXNORM
RXAUI 3104187 RXNORM
RXAUI 3258686 RXNORM
RXAUI 3258687 RXNORM
RXAUI 3261521 RXNORM
RXAUI 3298395 RXNORM
RXAUI 388381 RXNORM
RXAUI 4230907 RXNORM
RXCUI 18602 RXNORM
RXCUI 215499 RXNORM
RXCUI 352645 RXNORM
RXN_BN_CARDINALITY single RXNORM
SC 1 MSH
SID APRD00812 DRUGBANK
SID EXPT00598 DRUGBANK
SNOMEDID C-90005 SNOMEDCT_US
SNOMEDID F-61B45 SNOMEDCT_US
SOS RN given refers to parent cpd; structure MSH
SPL_SET_ID 0a6e9d2d-a13b-4fea-b0de-bd47dbc2ea2b MTHSPL
SPL_SET_ID 0d5269d5-6555-4d2c-bc3b-df862b014275 MTHSPL
SPL_SET_ID 1482d448-0f34-4aa6-b461-cb145404f6bc MTHSPL
SPL_SET_ID 28b8c519-8417-427e-8d4f-94da44a69d9f MTHSPL
SPL_SET_ID 2b3b6b62-364f-4aba-8024-3a73752b4c56 MTHSPL
SPL_SET_ID 487a7d1c-0f98-4d36-bfe9-c12bcda8d0b3 MTHSPL
SPL_SET_ID 62901840-4d72-4324-b89f-335022d2e5c0 MTHSPL
SPL_SET_ID 63773349-0295-4d56-a72e-0d7cade88ddb MTHSPL
SPL_SET_ID 675b60c8-573f-4863-9406-cd6caa11a2d1 MTHSPL
SPL_SET_ID 6c5e836c-2851-4524-b91d-12ffadffd9ba MTHSPL
SPL_SET_ID 94728fd8-9a86-4bd9-929c-7387765e604c MTHSPL
SPL_SET_ID 97bd2033-2cf0-4e5d-81e2-c453a1e3a65e MTHSPL
SPL_SET_ID b086c825-401e-48e7-a6dd-2ad7423e86a0 MTHSPL
SPL_SET_ID b0bf5462-bd6f-4233-aa03-344532f94271 MTHSPL
SPL_SET_ID b2d9b887-8e8e-4f12-a260-2f47e0f3870e MTHSPL
SPL_SET_ID c24a9fd8-1fb5-4643-92df-b268479a35e5 MTHSPL
SPL_SET_ID c4a3b80a-26d8-430c-9b7c-2e6de0fb2e7b MTHSPL
SPL_SET_ID c7c5af9c-935e-440d-a625-567936e0bae7 MTHSPL
SPL_SET_ID cc81df32-d949-4aac-9757-e1175005732a MTHSPL
SPL_SET_ID d0f5c24d-fee2-4a0c-9018-082d9f1bd54b MTHSPL
SPL_SET_ID d3f44051-9a13-4bcf-9783-f09286d86f4f MTHSPL
SPL_SET_ID d87ce1b1-1fed-4d8c-85d0-e1f687f634fc MTHSPL
SPL_SET_ID ebb71001-b324-4da0-bfc8-7403b8574778 MTHSPL
SPL_SET_ID ec6e2256-a9cb-4b5a-940e-fb2f4a340064 MTHSPL
SPL_SET_ID fc729ca5-3846-48fd-8d8c-d2b6a7563741 MTHSPL
SRC J Chromatogr 104(1):105;1975 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~m6A.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWoE SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-90005 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-61B45 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T085277 MSH
TERMUI T085278 MSH
TERMUI T461039 MSH
TERMUI T535456 MSH
TH FDA SRS (2015) MSH
TH INN (19XX) MSH
TH NLM (1969) MSH
TH NLM (2001) MSH
TH NLM (2003) MSH
TH USAN (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3596^Active/Master NDFRT
VANDF_RECORD 50.6^3312^Active/Master NDFRT
VUID 4020935 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0052761

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