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fomepizole (CUI C0048504) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0048504

NCI Thesaurus Code: C47538  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol dehydrogenase, thereby inhibiting the formation of their toxic metabolites, glycolate and oxalate (from ethylene glycol), and formic acid (from methanol). Fomepizole is indicated for use as an antidote in ethylene glycol and methanol poisoning. (NCI05)

Synonyms & Abbreviations: (see Synonym Details)
1H-Pyrazole, 4-methyl-
4-methylpyrazole
4-Methylpyrazol
Antizol
Fomepizole (substance)
fomepizole [Chemical/Ingredient]
Fomepizole
Fomepizolum
Fomepizol
Product containing fomepizole (medicinal product)
Product containing fomepizole

External Source Codes: 
NCI Thesaurus Code C47538 (see NCI Thesaurus info)
CAS Registry Number 7554-65-6 (see NLM ChemIDplus info)
FDA UNII Code 83LCM6L2BY

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:5141 NCI
Chemical_Formula C4H6N2 NCI
Contributing_Source FDA NCI
CTV3ID x053y SNOMEDCT_US
CTV3ID XUWom SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE 83LCM6L2BY DRUGBANK
FDA_UNII_CODE 83LCM6L2BY NDFRT
FR 482 MSH
HM D011720 MSH
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
MDA 19750101 MSH
MESH_DUI C010238 NDFRT
MESH_NAME fomepizole NDFRT
MESH_UI M0055591 NDFRT
MMR 20141027 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006381 NDFRT
NUI N0000148539 NDFRT
PA D000931 MSH
RN 0 MSH
RN 83LCM6L2BY MSH
RR 56010-88-9 (mono-HCl) MSH
RR 7554-65-6 (fomepizole) MSH
RXAUI 1016567 RXNORM
RXAUI 2629745 RXNORM
RXAUI 2987673 RXNORM
RXAUI 3021633 RXNORM
RXAUI 3093766 RXNORM
RXAUI 3158820 RXNORM
RXAUI 3158821 RXNORM
RXAUI 3260509 RXNORM
RXAUI 3260510 RXNORM
RXAUI 376642 RXNORM
RXAUI 376646 RXNORM
RXCUI 15226 RXNORM
RXCUI 157817 RXNORM
RXN_BN_CARDINALITY single RXNORM
SC 1 MSH
SID APRD00985 DRUGBANK
SOS alcohol dehyrogenase inhibitor MSH
SPL_SET_ID 463d32d2-56c0-43a6-b4da-6a5edce578b3 MTHSPL
SPL_SET_ID 7C6CA6E4-BE08-4BEA-8553-6B3374991A9E MTHSPL
SPL_SET_ID 911312e2-3a7c-4c97-88a8-b8d92cd12923 MTHSPL
SPL_SET_ID a306cd11-9acf-45f1-91ec-9fef2b08fdb1 MTHSPL
SPL_SET_ID c045b5a8-b220-4f0a-a831-155b29c19454 MTHSPL
SPL_SET_ID f82eb104-ac36-4908-96fe-9d64318597e8 MTHSPL
SRC Arch Biochem Biophys 1980;199(2):591 MSH
SRC Biochem Med 12(3):205;1975 MSH
SRC Biochem Pharmacol 27(1):7;1977 MSH
SRC Biochim Biophys Acta 1980;606(2):338 MSH
SRC Eur J Clin Invest 7(6):487;1977 MSH
SRC J Pharmacol Exp Ther 1979;211(1):135 MSH
SRC J Pharmacol Exp Ther 1980;213(1):70 MSH
SRC Metabolism 27(6):631;1978 MSH
SRC Proc Natl Acad Sci USA 1979;76(7):3499 MSH
SUBSET_MEMBER 900000000000497000~MAPTARGET~x053y SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWom SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T085592 MSH
TERMUI T085593 MSH
TERMUI T085594 MSH
TH CA MSH
TH NLM (1975) MSH
TH NLM (1987) MSH
TH UK MSH
TH USAN (1990) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3749^Active/Master NDFRT
VANDF_RECORD 50.6^3473^Active/Master NDFRT
VUID 4021081 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0048504

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