|Terms & Properties|
Concept Unique Identifier (CUI): C0042900
NCI Thesaurus Code: C26915 (see NCI Thesaurus info)
Semantic Type: Disease or Syndrome
NCIt Definition: Generalized well circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes.
GARD Definition: Vitiligo is a pigmentation disorder in which melanocytes (the cells that make pigment) in the skin are destroyed. As a result, white patches appear on the skin in different parts of the body, and sometimes also on both the mucous membranes and the retina. The average age of onset is in the mid-20s. It is generally considered to be an autoimmune disorder, and about 20-25 percent of people with vitiligo also have at least one other autoimmune disorder. In the absence of other conditions, vitiligo does not affect general health; however, concerns about appearance and ethnic identity are significant issues for many affected individuals. The exact cause of vitiligo is not known, but there are several different theories. There is strong evidence that people with vitiligo inherit a group of genes that make them susceptible to depigmentation. The main goal of treating vitiligo is to improve appearance; current treatment options include medication, surgery, and adjunctive therapies (used along with surgical or medical treatments). - this information is from GARD/ORDR/NCATS.
Vitiligo causes white patches on your skin. It can also affect your eyes, mouth, and nose. It occurs when the cells that give your skin its color are destroyed. No one knows what destroys them. It is more common in people with autoimmune diseases, and it might run in families. It usually starts before age 40.
The white patches are more common where your skin is exposed to the sun. In some cases, the patches spread. Vitiligo can cause your hair to gray early. If you have dark skin, you may lose color inside your mouth.
Using sunscreen will help protect your skin, and cosmetics can cover up the patches. Treatments for vitiligo include medicines, light therapy, and surgery. Not every treatment is right for everyone. Many have side effects. Some take a long time. Some do not always work.
NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases
NICHD Definition: Generalized well circumscribed patches of leukoderma that is generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes.
CSP Definition: usually progressive, chronic pigmentary anomaly of the skin manifested by depigmented white patches that may be surrounded by a hyperpigmented border.
MSH Definition: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
Synonyms & Abbreviations: (see Synonym Details)
|Blotchy loss of skin color|
External Source Codes:
|NCI Thesaurus Code||C26915 (see NCI Thesaurus info)|
|AQL||BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI||MSH|
|EXCLUDES2||vitiligo of eyelids (H02.73-)||ICD10CM|
|EXCLUDES2||vitiligo of vulva (N90.89)||ICD10CM|
|MESH_DEFINITION||A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.||NDFRT|
|MP_PRIMARY_INSTITUTE_URL||National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov/||MEDLINEPLUS|
|PRIMARY_PATH||10047642$10021064$10035023$10040785$Vitiligo$Hypopigmentation disorders$Pigmentation disorders$Skin and subcutaneous tissue disorders||MDR|
|SUBSET_MEMBER||6011000124106~MAPADVICE~ALWAYS L80 | DESCENDANTS NOT EXHAUSTIVELY MAPPED||SNOMEDCT_US|
Additional Concept Data: (none)