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Urea (CUI C0041942) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0041942

NCI Thesaurus Code: C29531  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

Semantic Type: Biologically Active Substance

NCIt Definition: A nitrogenous compound containing a carbonyl group attached to two amine groups with osmotic diuretic activity. In vivo, urea is formed in the liver via the urea cycle from ammonia and is the final end product of protein metabolism. Administration of urea elevates blood plasma osmolality, resulting in enhanced flow of water from tissues, including the brain, cerebrospinal fluid and eye, into interstitial fluid and plasma, thereby decreasing pressure in those tissues and increasing urine outflow.

NCI-GLOSS Definition: A substance formed by the breakdown of protein in the liver. The kidneys filter carbamide out of the blood and into the urine. Carbamide can also be made in the laboratory. A topical form of carbamide is being studied in the treatment of hand-foot syndrome (pain, swelling, numbness, tingling, or redness of the hands or feet that may occur as a side effect of certain anticancer drugs).

CSP Definition: CO(NH2)2; compound formed in the liver via the urea cycle and excreted by the kidney; principal end product of protein catabolism.

MSH Definition: A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.

Synonyms & Abbreviations: (see Synonym Details)
57-13-6
Aqua Care
Carbamide
Carbonyldiamide
Elaqua XX
Lanaphilic
Nutraplus
Product containing urea (medicinal product)
Product containing urea
Urea (substance)
Urea [Chemical/Ingredient]
Ureaphil
urea
Vanamide

External Source Codes: 
NCI Thesaurus Code C29531 (see NCI Thesaurus info)
CAS Registry Number 57-13-6 (see NLM ChemIDplus info)
FDA UNII Code 8W8T17847W
NSC Code 34375 (see NCI DTP info)
PDQ Closed Trial Search ID 40286
PDQ Open Trial Search ID 40286 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:16199 NCI
Chemical_Formula CH4N2O NCI
Contributing_Source FDA NCI
CTV3ID b62.. SNOMEDCT_US
CTV3ID XUWqm SNOMEDCT_US
DATE_LAST_MODIFIED 2014-10-02 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0113-3157 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE 8W8T17847W DRUGBANK
FDA_UNII_CODE 8W8T17847W NDFRT
FX D001806 MSH
LEVEL Ingredient NDFRT
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. NDFRT
MESH_DUI D014508 NDFRT
MESH_NAME Urea NDFRT
MESH_UI M0022315 NDFRT
MMR 20130708 MSH
MN D02.948 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C29531 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006999 NDFRT
NUI N0000146756 NDFRT
ORIG_STY Drug/agent PDQ
PID 3124 PDQ
RN 8W8T17847W MSH
RR 57-13-6 (Urea) MSH
RXAUI 1174964 RXNORM
RXAUI 1181267 RXNORM
RXAUI 1552376 RXNORM
RXAUI 1913643 RXNORM
RXAUI 2075147 RXNORM
RXAUI 3035331 RXNORM
RXAUI 3129880 RXNORM
RXAUI 3252188 RXNORM
RXAUI 3252189 RXNORM
RXAUI 3252709 RXNORM
RXAUI 3252711 RXNORM
RXAUI 3280276 RXNORM
RXAUI 3280390 RXNORM
RXAUI 350839 RXNORM
RXCUI 11002 RXNORM
RXCUI 215369 RXNORM
RXCUI 218820 RXNORM
RXCUI 224951 RXNORM
RXCUI 353069 RXNORM
RXN_BN_CARDINALITY single RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
RXN_OBSOLETED 09/30/2013 RXNORM
SID EXPT03203 DRUGBANK
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SPL_SET_ID fa69dfdf-ab73-48a9-944d-25e88d7766df MTHSPL
SPL_SET_ID fadd572c-05ff-45fb-bd44-cc9b3827d469 MTHSPL
SPL_SET_ID fb991214-8aaa-4c5d-bbc9-f099a1f64049 MTHSPL
SPL_SET_ID fc4806e4-234a-49fc-b205-c25f43db041d MTHSPL
SPL_SET_ID fd6343a9-15a6-4894-b51f-122e4d6dbe79 MTHSPL
SPL_SET_ID fd79346a-fba3-49ec-9cd3-5c00bedb4acb MTHSPL
SPL_SET_ID fd7b3fe5-8ba6-4808-8ead-1b20a87a2ed2 MTHSPL
SPL_SET_ID feaa5775-0c49-4922-a3f1-b706d6aa7470 MTHSPL
SPL_SET_ID fee71618-533b-41c8-bbdd-0a7ff68509b8 MTHSPL
SPL_SET_ID ffa6ddc5-4017-4eb9-8887-5f7c7d1f5525 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~b62.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWqm SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T042462 MSH
TERMUI T042464 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1028^Active/Master NDFRT
VANDF_RECORD 50.6^1013^Active/Master NDFRT
VUID 4018430 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0041942

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