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Chagas Disease (CUI C0041234) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0041234

NCI Thesaurus Code: C84629  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A parasitic infection caused by Trypanosoma cruzi. It is transmitted by insect bites. It is characterized by an acute and chronic phase; in the acute phase patients may have fever, malaise, and swelling at the site of the insect bite. In the chronic phase patients develop hepatosplenomegaly, lymphadenopathy, cardiomyopathy and arrhythmias.

GARD Definition: Chagas disease is caused by the parasiteTrypanosoma cruzi. When a triatomine bug (commonly known as a "kissing bug") infected with this parasite bites you, usually on your face, it leaves behind infected waste which can be spread into your eyes, nose, or a wound. Chagas disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. Symptoms can include fever, flu-like symptoms, a rash or swollen eyelid. Early symptoms usually go away but if not treated, the infection can later cause serious intestinal and heart problems. Chagas disease is common in Latin America but not in the United States. - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Chagas disease is caused by a parasite. It is common in Latin America but not in the United States. Infected blood-sucking bugs, sometimes called kissing bugs, spread it. When the bug bites you, usually on your face, it leaves behind infected waste. You can get the infection if you rub it in your eyes or nose, the bite wound or a cut. The disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy.

If you notice symptoms, they might include

  • Fever
  • Flu-like symptoms
  • A rash
  • A swollen eyelid

These early symptoms usually go away. However, if you don't treat the infection, it stays in your body. Later, it can cause serious intestinal and heart problems.

A physical exam and blood tests can diagnose it. You may also need tests to see whether the disease has affected your intestines and heart.

Medicines can kill the parasite, especially early on. You can also treat related problems. For example, a pacemaker helps with certain heart complications.

Centers for Disease Control and Prevention

NICHD Definition: A protozoan infection that is caused by Trypanosoma cruzi; it is transmitted by triatomine insects, and is characterized by acute (fever and local swelling) and chronic (hepatosplenomegaly, lymphadenopathy, cardiomyopathy) phases.

MSH Definition: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.

Synonyms & Abbreviations: (see Synonym Details)
American trypanosomiasis NOS
American trypanosomiasis
Chagas Disease [Disease/Finding]
Chagas Disease
CHAGAS DIS
Chagas' disease
Chagas-Mazza disease
Disease, Chagas'
Disease, Chagas
Infection by Trypanosoma cruzi
Infection caused by Trypanosoma cruzi (disorder)
Infection caused by Trypanosoma cruzi
New world trypanosomiasis
South American trypanosomiasis
T.cruzi
Trypanosoma cruzi infection
TRYPANOSOMIASIS, AMERICAN
TRYPANOSOMIASIS, BRAZILIAN
Trypanosomiasis, South American

External Source Codes: 
NCI Thesaurus Code C84629 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate with NEGLECTED DISEASES if pertinent; CHAGAS CARDIOMYOPATHY is also available. MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID X00CV SNOMEDCT_US
DATE_CREATED 11/24/2003 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DID 2214-6161 CSP
DISEASE_IDENTIFIER_ID 17733 GARD
DISEASE_IDENTIFIER_ID 17734 GARD
DISEASE_IDENTIFIER_ID 17735 GARD
DX 19920101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 92; was TRYPANOSOMIASIS, SOUTH AMERICAN 1966-91; CHAGAS DISEASE was see TRYPANOSOMIASIS, SOUTH AMERICAN 1981-91 MSH
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM American trypanosomiasis ICD10
INCLUSION_TERM infection due to Trypanosoma cruzi ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Modified GARD
LAST_REVIEW_DATE 2014-03-04T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. NDFRT
MESH_DUI D014355 NDFRT
MESH_NAME Chagas Disease NDFRT
MESH_UI M0022076 NDFRT
MMR 20121204 MSH
MN C03.752.300.900.200 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/chagasdisease.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/chagasdisease.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Chagas Disease NCI
NUI N0000003028 NDFRT
OL use CHAGAS DISEASE to search TRYPANOSOMIASIS, SOUTH AMERICAN 1966-91 MSH
ORDER_NO 01049 ICD10CM
PM 92; was TRYPANOSOMIASIS, SOUTH AMERICAN 1966-91; CHAGAS DISEASE was see TRYPANOSOMIASIS, SOUTH AMERICAN 1981-91 MSH
PRIMARY_PATH 10001935$10044708$10037072$10021881$American trypanosomiasis$Trypanosomal infections$Protozoal infectious disorders$Infections and infestations MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/6030/chagas-disease/resources/1 GARD
RXAUI 3108072 RXNORM
RXAUI 3132020 RXNORM
RXAUI 3132021 RXNORM
RXAUI 3132023 RXNORM
RXAUI 3251040 RXNORM
RXCUI 1024452 RXNORM
SNOMED_CID 77506005 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS B57.2 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~B57.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS B57.2 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B57.2 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X00CV SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T041997 MSH
TERMUI T041998 MSH
TERMUI T041999 MSH
TERMUI T549201 MSH
TH NLM (1981) MSH
TH NLM (1992) MSH
TH NLM (2005) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0041234

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