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Gilles de la Tourette syndrome (CUI C0040517) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0040517

NCI Thesaurus Code: C35078  (see NCI Thesaurus info)

Semantic Type: Mental or Behavioral Dysfunction

NCIt Definition: A neurologic disorder caused by defective metabolism of the neurotransmitters in the brain. It is characterized by repeated involuntary movements (motor tics) and uncontrollable vocal sounds (vocal tics). The symptoms are usually manifested before the age of eighteen.

GARD Definition: 

Tourette syndrome is a disorder of the nervous system that causes a person to make repeated and uncontrolled (involuntary) movements and sounds (vocalizations) called tics. Tourette syndrome is named for Georges Gilles de la Tourette, who first described this disorder in 1885. There is strong evidence that Tourette syndrome is passed down through families, although the gene has not yet been found. The syndrome may be linked to problems in certain areas of the brain, and the chemical substances (dopamine, serotonin, and norepinephrine) that help nerve cells talk to one another. Tourette syndrome can be either severe or mild. It is estimated that about 1% of the population has Tourette syndrome. Many people with very mild tics may not be aware of them and never seek medical help.   Tourette syndrome is four times as likely to occur in boys as in girls.   Although Tourette syndrome can be a chronic condition with symptoms lasting a lifetime, most people with the condition experience their worst symptoms in their early teens, with improvement occurring in the late teens and continuing into adulthood.

- this information is from GARD/ORDR/NCATS.

MSH Definition: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

MEDLINEPLUS Definition: 

If you have Tourette syndrome, you make unusual movements or sounds, called tics. You have little or no control over them. Common tics are throat-clearing and blinking. You may repeat words, spin, or, rarely, blurt out swear words.

Tourette syndrome is a disorder of the nervous system. It often occurs with other problems, such as

The cause of Tourette syndrome is unknown. It is more common in boys than girls. The tics usually start in childhood and may be worst in the early teens. Many people eventually outgrow them.

No treatment is needed unless the tics interfere with everyday life. Excitement or worry can make tics worse. Calm, focused activities may make them better. Medicines and talk therapy may also help.

NIH: National Institute of Neurological Disorders and Stroke

NICHD Definition: A neurological disorder presenting in childhood that is characterized by both motor and phonic tics that occur daily or nearly daily for at least a year and are not attributed to an identifiable cause.

CSP Definition: neuropsychological disorder related to alterations in dopamine metabolism and neurotransmission involving frontal-subcortical neuronal circuits; both multiple motor and one or more vocal tics need to be present with tics occurring many times a day, nearly daily, over a period of more than one year; disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning.

Synonyms & Abbreviations: (see Synonym Details)
Brissaud's II
Chronic Motor and Vocal Tic Disorder
Combined Multiple Motor and Vocal Tic Disorder
COMBINED MULTIPLE MOTOR VOCAL TIC DIS
Combined vocal and multiple motor tic disorder [de la Tourette]
Combined Vocal and Multiple Motor Tic Disorder
COMBINED VOCAL MULTIPLE MOTOR TIC DIS
GILLES DE LA TOURETTE DIS
GILLES DE LA TOURETTE SYNDROME
Gilles de la Tourette's Disease
Gilles de la Tourette's disorder
Gilles de la Tourette's syndrome (disorder)
Gilles de la Tourette's syndrome
Gilles de la Tourette's
Gilles de la Tourettes syndrome
GILLES DE LA TOURETTE
GTS
Guinon's disease
Guinon's myospasia impulsiva
maladie des tics
motor-verbal tic disorders
Motor-verbal tic disorder
Multiple Motor and Vocal Tic Disorder, Combined
MULTIPLE MOTOR VOCAL TIC DIS COMBINED
SYNDROME GILLES DE LA TOURETTE
SYNDROME TOURETTE
Syndrome, Tourette
tic de Guinon
TIC DIS COMBINED VOCAL MULTIPLE MOTOR
Tic Disorder, Combined Vocal and Multiple Motor
Tourette Disease
TOURETTE DISORDER
TOURETTE DIS
Tourette Syndrome [Disease/Finding]
Tourette Syndrome
Tourette's Disease
Tourette's disorder
Tourette's syndrome
Tourettes Disease
Tourettes Disorder
TOURETTES DIS
Tourettes syndrome
TS

External Source Codes: 
NCI Thesaurus Code C35078 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source MedDRA NCI
Contributing_Source NICHD NCI
CTV3ID E2723 SNOMEDCT_US
DATE_CREATED 07/01/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2042-5068 CSP
DISEASE_IDENTIFIER_ID 6177 GARD
DISEASE_IDENTIFIER_ID 6178 GARD
DISEASE_IDENTIFIER_ID 6179 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FX D020323 MSH
GENELOCUS ,1,3,q,3,1, OMIM
GENESYMBOL KIAA1910 OMIM
GENESYMBOL SLITRK1 OMIM
GENESYMBOL TTM OMIM
HAS_GARD_PAGE true GARD
HN 1989(1966) MSH
HN ETOH descriptor 2000. AOD
IAN DEFAULT ICD10
ICE Motor-verbal tic disorder ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a another medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79) NDFRT
MESH_DUI D005879 NDFRT
MESH_NAME Tourette Syndrome NDFRT
MESH_UI M0009230 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20150630 MSH
MN C10.228.140.079.898 MSH
MN C10.228.662.825.800 MSH
MN C10.574.500.850 MSH
MN C16.320.400.820 MSH
MN F03.625.992.850 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/tourettesyndrome.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/tourettesyndrome.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Tourette Syndrome NCI
NUI N0000001334 NDFRT
ORDER_NO 05738 ICD10CM
PM 1989; see GILLES DE LA TOURETTE'S DISEASE 1966-88 MSH
PRIMARY_PATH 10044126$10029300$10029299$10010331$Tourette's disorder$Neurological disorders congenital NEC$Neurological disorders congenital$Congenital, familial and genetic disorders MDR
PRIMARY_SOC 10010331 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7783/tourette-syndrome/resources/1 GARD
RXAUI 3134622 RXNORM
RXAUI 3134624 RXNORM
RXAUI 3165420 RXNORM
RXAUI 3165421 RXNORM
RXAUI 3200095 RXNORM
RXAUI 3248805 RXNORM
RXAUI 3249365 RXNORM
RXAUI 3249366 RXNORM
RXAUI 3249367 RXNORM
RXAUI 3249368 RXNORM
RXAUI 3249369 RXNORM
RXAUI 3249370 RXNORM
RXAUI 3249371 RXNORM
RXAUI 5930571 RXNORM
RXAUI 5931037 RXNORM
RXCUI 1024192 RXNORM
SMQ_TERM_ADDVERSION 10.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 14.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 5158005 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS F95.2 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~F95.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS F95.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF DYSPHONIA OF GILLES DE LA TOURETTE'S SYNDROME CHOOSE R49.0 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 23772009 | Dysphonia of Gilles de la Tourette's syndrome | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F95.2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~R49.0 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~E2723 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T017777 MSH
TERMUI T017778 MSH
TERMUI T017779 MSH
TERMUI T017780 MSH
TERMUI T017781 MSH
TERMUI T017782 MSH
TERMUI T364588 MSH
TERMUI T364589 MSH
TERMUI T364590 MSH
TERMUI T364591 MSH
TERMUI T364592 MSH
TERMUI T364593 MSH
TERMUI T842591 MSH
TERMUI T842592 MSH
TH GHR (2014) MSH
TH NLM (1965) MSH
TH NLM (2000) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0040517

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