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Tobramycin (CUI C0040341) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0040341

NCI Thesaurus Code: C62082  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and interferes with the initiation complex between messenger RNA and the 30S subunit, thereby inhibiting initiation of protein synthesis, consequently leading to bacterial cell death. In addition, tobramycin induces misreading of the mRNA template causing incorrect amino acids to be incorporated into the growing polypeptide chain, consequently interfering with protein elongation.

MSH Definition: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

Synonyms & Abbreviations: (see Synonym Details)
3'-Deoxykanamycin b
D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl-(1-4))-2-deoxy-
Nebramycin 6
Nebramycin factir 6
Nebramycin Factor 6
Nebramycin-Faktor 6
O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine
Product containing tobramycin (medicinal product)
Product containing tobramycin
TBM
Tobramicina
Tobramycin (substance)
Tobramycin [Chemical/Ingredient]
Tobramycine
Tobramycinum
tobramycin

External Source Codes: 
NCI Thesaurus Code C62082 (see NCI Thesaurus info)
CAS Registry Number 32986-56-4 (see NLM ChemIDplus info)
FDA UNII Code VZ8RRZ51VK

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:28864 NCI
Chemical_Formula C18H37N5O9 NCI
Contributing_Source FDA NCI
CTV3ID x02Ls SNOMEDCT_US
CTV3ID XUWKI SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0191-7378 CSP
DX 19840101 MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE VZ8RRZ51VK DRUGBANK
FDA_UNII_CODE VZ8RRZ51VK NDFRT
HN 84(75); was see under ANTIBIOTICS 1975-83 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19741111 MSH
MESH_DEFINITION An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species. NDFRT
MESH_DUI D014031 NDFRT
MESH_NAME Tobramycin NDFRT
MESH_UI M0021611 NDFRT
MMR 20130708 MSH
MN D09.408.051.476.600.800 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005883 NDFRT
NUI N0000146911 NDFRT
PA D000900 MSH
PM 84; was see under ANTIBIOTICS 1975-83 MSH
RN VZ8RRZ51VK MSH
RR 32986-56-4 (Tobramycin) MSH
RR HJT0RXD7JK MSH
RXAUI 2074859 RXNORM
RXAUI 2600578 RXNORM
RXAUI 2932020 RXNORM
RXAUI 3137839 RXNORM
RXAUI 3204703 RXNORM
RXAUI 3245711 RXNORM
RXAUI 3245712 RXNORM
RXAUI 3248999 RXNORM
RXAUI 3249002 RXNORM
RXAUI 339753 RXNORM
RXAUI 4241587 RXNORM
RXCUI 10627 RXNORM
SID APRD00582 DRUGBANK
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SUBSET_MEMBER 900000000000497000~MAPTARGET~x02Ls SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWKI SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T041153 MSH
TERMUI T041154 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TH USAN (1972) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1194^Active/Master NDFRT
VANDF_RECORD 50.6^914^Active/Master NDFRT
VUID 4018595 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0040341

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