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Thyrotropin-Releasing Hormone (CUI C0040162) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0040162

NCI Thesaurus Code: C136413  (see NCI Thesaurus info)

Semantic Type: Hormone

Semantic Type: Pharmacologic Substance

Semantic Type: Amino Acid, Peptide, or Protein

NCIt Definition: Thyrotropin-releasing hormone (3 aa, ~0.4 kDa) is encoded by the human TRH gene. This protein plays a role in the positive regulation of thyrotropin (thyroid-stimulating hormone; TSH) production and release.

CSP Definition: tripeptide hormone elaborated by the median eminence of the hypothalamus which stimulates release of thyrotropin from the anterior pituitary gland.

MSH Definition: A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.

Synonyms & Abbreviations: (see Synonym Details)
5-oxo-L-prolyl-L-histidyl-L-prolinamide
L-pyroglutamyl-L-histidyl-L-prolineamide
Product containing thyrotropin releasing hormone (medicinal product)
Product containing thyrotropin releasing hormone
Protirelin
pyroGlu-His-Pro-NH2 (or 5-oxo-L-prolyl-L-histidyl-L-prolinamide)
Thyrel TRH
Thyroliberin TRH Merck
Thyroliberin
Thyrotrophin releasing hormone
Thyrotropic releasing hormone
Thyrotropic-releasing factor
Thyrotropin releasing factor (substance)
Thyrotropin releasing factor agent (substance)
Thyrotropin releasing factor agent
Thyrotropin Releasing Factor
thyrotropin releasing hormone
thyrotropin RH
Thyrotropin-releasing factor
Thyrotropin-Releasing Hormone [Chemical/Ingredient]
thyrotropin-releasing hormone
TRF
TRH - Thyrotrophin releasing hormone
TRH
TSH-releasing factor
TSH-releasing hormone

External Source Codes: 
NCI Thesaurus Code C136413 (see NCI Thesaurus info)
OMIM Number 613879 (see OMIM info)
Swiss Prot P20396 (see UniProt/Swiss-Prot info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT DE DF EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
AUTHORITY Gray's 99:1900-1901 Table 15.1 FMA
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID fq3.. SNOMEDCT_US
CTV3ID X80Gd SNOMEDCT_US
CTV3ID XUc2U SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2334-6001 CSP
DX 19680101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20040731 SNOMEDCT_US
FDA_UNII_CODE 5Y5F15120W DRUGBANK
FDA_UNII_CODE 5Y5F15120W NDFRT
FX D018025 MSH
HN 2006(1968) MSH
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
MDA 19990101 MSH
MESH_DEFINITION A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND. NDFRT
MESH_DUI D013973 NDFRT
MESH_NAME Thyrotropin-Releasing Hormone NDFRT
MESH_UI M0021497 NDFRT
MMR 20160701 MSH
MN D06.472.699.327.740.880 MSH
MN D12.644.400.400.740.880 MSH
MN D12.644.456.837 MSH
MN D12.644.548.365.740.880 MSH
MN D12.776.631.650.405.740.880 MSH
MN D12.776.631.650.810 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000146792 NDFRT
NUI N0000170390 NDFRT
PA D006728 MSH
PM 2006; see PROTIRELIN 1992-2005, see THYROTROPIN-RELEASING HORMONE 1991, see THYROTROPIN RELEASING HORMONE 1974-1990, see THYROTROPIN RELEASING FACTOR 1968-1973 MSH
RN 0 MSH
RN 5Y5F15120W MSH
RR 1N3H4TJE79 MSH
RR 24305-27-9 (Thyrotropin-Releasing Hormone) MSH
RR SYW8T997EQ MSH
RXAUI 1183956 RXNORM
RXAUI 2074077 RXNORM
RXAUI 3216910 RXNORM
RXAUI 3216911 RXNORM
RXAUI 3225234 RXNORM
RXAUI 3248759 RXNORM
RXAUI 3248760 RXNORM
RXAUI 3248762 RXNORM
RXAUI 3262293 RXNORM
RXAUI 337999 RXNORM
RXAUI 4648126 RXNORM
RXCUI 10580 RXNORM
RXCUI 220308 RXNORM
RXN_OBSOLETED 03/27/2013 RXNORM
SPL_SET_ID af5da799-76bf-415a-9dc7-99c7ddc62bc4 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~fq3.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80Gd SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUc2U SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T040973 MSH
TERMUI T040975 MSH
TERMUI T040983 MSH
TERMUI T665155 MSH
TERMUI T671772 MSH
TH BAN (19XX) MSH
TH DE MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH JAN (19XX) MSH
TH NLM (1992) MSH
TH NLM (2007) MSH
TH NLM (2014) MSH
TH UNK (19XX) MSH
TH USAN (1974) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1067^Active/Master NDFRT
VANDF_RECORD 50.6^779^Active/Master NDFRT
VUID 4018469 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0040162

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