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Tetrahydrocannabinol (CUI C0039663) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0039663

NCI Thesaurus Code: C867  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: An isomer of tetrahydrocannabinol (THC) that is the main and most active isomer found in the cannabis sativa L. plant, with potential anti-emetic, analgesic and appetite stimulating activities. Upon administration, dronabinol, also called delta-9-THC, targets and binds to cannabinoid receptors (CBRs) located in the central nervous system (CNS). Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. In addition, this agent induces analgesia. Urine levels may be used as a marker to determine the exposure to certain preparations containing parts of the cannabis plant, such as marijuana.

MSH Definition: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.

PDQ Definition: An isomer of tetrahydrocannabinol (THC) that is the main and most active isomer found in the cannabis sativa L. plant, with potential anti-emetic, analgesic and appetite stimulating activities. Upon administration, dronabinol, also called delta-9-THC, targets and binds to cannabinoid receptors (CBRs) located in the central nervous system (CNS). Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. In addition, this agent induces analgesia. Urine levels may be used as a marker to determine the exposure to certain preparations containing parts of the cannabis plant, such as marijuana. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A synthetic pill form of delta-9-tetrahydrocannabinol (THC), an active ingredient in marijuana that is used to treat nausea and vomiting associated with cancer chemotherapy.

Synonyms & Abbreviations: (see Synonym Details)
(-)-.DELTA.9-Tetrahydrocannabinol
(-)-delta9-trans-Tetrahydrocannabinol
1-trans-delta-9-Tetrahydrocannabinol
3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol
6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
9 ene Tetrahydrocannabinol
9-ene-Tetrahydrocannabinol
Abbott 40566
Delta 9-Tetrahydrocannabinol
DELTA THC 09
delta(1)-Tetrahydrocannabinol
delta(1)-THC
delta(9)-Tetrahydrocannabinol
Delta(9)-Tetrahydrocannibinol
delta(9)-THC
delta-9-Tetrahydrocannabinol (substance)
delta-9-tetrahydrocannabinol
delta-9-THC
delta9-Tetrahydrocannabinol
Delta9-THC
Dronabinol (substance)
Dronabinol [Chemical/Ingredient]
Dronabinolum
Dronabinol
Marinol
Product containing dronabinol (medicinal product)
Product containing dronabinol
SP 104
SP-104
Synthetic delta-9-Tetrahydrocannabinol
Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-dibenzo(b,d)pyran-1-ol
Tetrahydrocannabinol (substance)
tetrahydrocannabinol
THC
Δ9-tetrahydrocannabinol

External Source Codes: 
NCI Thesaurus Code C867 (see NCI Thesaurus info)
CAS Registry Number 1972-08-3 (see NLM ChemIDplus info)
FDA UNII Code 7J8897W37S
NSC Code 134454 (see NCI DTP info)
PDQ Closed Trial Search ID 39707
PDQ Open Trial Search ID 39707 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C21H30O2 NCI
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID XU27h SNOMEDCT_US
CTV3ID XUJfM SNOMEDCT_US
CTV3ID XUOeA SNOMEDCT_US
CTV3ID XUWml SNOMEDCT_US
DATE_LAST_MODIFIED 2016-07-29 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0396-2636 CSP
DX 19770101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
EFFECTIVE_TIME 20080131 SNOMEDCT_US
FDA_UNII_CODE 7J8897W37S DRUGBANK
FDA_UNII_CODE 7J8897W37S NDFRT
HN 2014(1971); MSH
HN ETOH descriptor 1995. AOD
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
LT TRD MSH
LT TRD MTH
LT TRD PDQ
MDA 19990101 MSH
MESH_DEFINITION A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. NDFRT
MESH_DUI D013759 NDFRT
MESH_NAME Dronabinol NDFRT
MESH_UI M0021229 NDFRT
MMR 20160701 MSH
MN D02.455.849.090.810 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C867 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006283 NDFRT
NUI N0000146833 NDFRT
ORIG_STY Drug/agent PDQ
PA D006213 MSH
PA D011619 MSH
PA D018712 MSH
PA D063386 MSH
PID 2369 PDQ
PM 2014; seeTETRAHDYROCANNABINOL 1971-2013 MSH
RN 0 MSH
RN 7J8897W37S MSH
RR 17766-02-8 MSH
RR 1972-08-3 (Tetrahydrocannabinol) MSH
RR 3556-79-4 MSH
RR 43009-38-7 MSH
RR 6465-30-1 MSH
RR 69855-10-3 MSH
RXAUI 1190064 RXNORM
RXAUI 2070666 RXNORM
RXAUI 2637964 RXNORM
RXAUI 3094483 RXNORM
RXAUI 3094708 RXNORM
RXAUI 3142833 RXNORM
RXAUI 3142834 RXNORM
RXAUI 3244317 RXNORM
RXAUI 3259970 RXNORM
RXAUI 3259972 RXNORM
RXAUI 3259974 RXNORM
RXAUI 3259975 RXNORM
RXAUI 3304289 RXNORM
RXAUI 332691 RXNORM
RXAUI 3868354 RXNORM
RXAUI 5930758 RXNORM
RXAUI 5930759 RXNORM
RXAUI 5932351 RXNORM
RXAUI 5933125 RXNORM
RXCUI 10402 RXNORM
RXCUI 224925 RXNORM
RXN_BN_CARDINALITY single RXNORM
SID APRD00571 DRUGBANK
SOS Active ingredient of hashish. AOD
SOS Tetrahydrocannabinol, a psychoactive alkaloid of the cannabis plant, first synthesized in 1965. One of many cannabis derivatives, it is believed to produce the primary psychoactive effects of marijuana. Hashish usually contains about 12 percent THC and up to 40 percent hash oil. Because pure THC is expensive to produce and loses its potency rapidly upon exposure to air, much of what is sold on the streets as THC is PCP or LSD. AOD
SPL_SET_ID 08adbfd9-789a-4888-a9e2-2a6dac867885 MTHSPL
SPL_SET_ID 1f1af798-17d5-47d0-b129-21d4aa1eb125 MTHSPL
SPL_SET_ID 5050ed63-c6bc-4761-9a81-ef8e5f3f378e MTHSPL
SPL_SET_ID 5bbac0b1-ddc2-400b-8e0d-1e1d484720ca MTHSPL
SPL_SET_ID 68b4168b-5782-4e68-a25a-5b4e4408dbce MTHSPL
SPL_SET_ID a0409d82-a61e-4b9e-8717-ced299ccedb2 MTHSPL
SPL_SET_ID a6269fc3-ca40-444f-8035-d6a391d037e0 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~XU27h SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUJfM SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUOeA SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWml SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T040421 MSH
TERMUI T040422 MSH
TERMUI T040423 MSH
TERMUI T040424 MSH
TERMUI T040425 MSH
TERMUI T040426 MSH
TERMUI T040427 MSH
TERMUI T040428 MSH
TERMUI T040429 MSH
TH CA MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1971) MSH
TH NLM (1992) MSH
TH NLM (1994) MSH
TH NLM (1997) MSH
TH UNK (19XX) MSH
TH USAN (1984) MSH
TH USP (19XX) MSH
TH US MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^1109^Active/Master NDFRT
VANDF_RECORD 50.6^827^Active/Master NDFRT
VUID 4018511 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0039663

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