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Tetracycline (CUI C0039644) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0039644

NCI Thesaurus Code: C865  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Antibiotic

NCIt Definition: A broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline binds to the 30S ribosomal subunit, interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.

NCI-GLOSS Definition: A drug used to treat bacterial infections. It stops the growth of bacteria by keeping them from making proteins. Tetracycline also binds to new bone tissue and is being studied as a way to detect bone growth. Tetracycline is a type of antibiotic and a type of bone-labeling agent.

MSH Definition: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.

Synonyms & Abbreviations: (see Synonym Details)
(4S,4AS,5as,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-
4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide
Product containing tetracycline (medicinal product)
Product containing tetracycline
TCN
Tetracycline (substance)
Tetracycline [Chemical/Ingredient]
Tetracycline
Tetracyclinum
Tetracyclin
Tetrazyklin
TETRA
Tsiklomitsin
T├ętracycline

External Source Codes: 
NCI Thesaurus Code C865 (see NCI Thesaurus info)
CAS Registry Number 60-54-8 (see NLM ChemIDplus info)
FDA UNII Code F8VB5M810T
NSC Code 108579 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AD AE AG AI AN BI BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:27902 NCI
Chemical_Formula C22H24N2O8 NCI
Contributing_Source FDA NCI
CTV3ID x02Lq SNOMEDCT_US
CTV3ID XUW19 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19660101 MSH
EC analogs & derivatives:Tetracyclines MSH
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE F8VB5M810T DRUGBANK
FDA_UNII_CODE F8VB5M810T NDFRT
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis. NDFRT
MESH_DUI D013752 NDFRT
MESH_NAME Tetracycline NDFRT
MESH_UI M0021216 NDFRT
MMR 20130708 MSH
MN D02.455.426.559.847.562.900.875 MSH
MN D04.615.562.900.875 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006275 NDFRT
NUI N0000146005 NDFRT
PA D000900 MSH
PA D011500 MSH
RN F8VB5M810T MSH
RR 60-54-8 (Tetracycline) MSH
RR 64-75-5 (mono-HCl) MSH
RR P6R62377KV MSH
RXAUI 2074747 RXNORM
RXAUI 3092565 RXNORM
RXAUI 3244175 RXNORM
RXAUI 3244176 RXNORM
RXAUI 3247764 RXNORM
RXAUI 3247770 RXNORM
RXAUI 332468 RXNORM
RXAUI 5470608 RXNORM
RXAUI 6396003 RXNORM
RXAUI 6396467 RXNORM
RXCUI 10395 RXNORM
SID APRD00572 DRUGBANK
SPL_SET_ID 023bc2ec-bd7d-440a-b21b-a2f1ff48c15a MTHSPL
SPL_SET_ID 13a23307-61e4-4094-9132-68e38d200d18 MTHSPL
SPL_SET_ID 1430eca0-ca85-4852-a0c0-032a96b845e2 MTHSPL
SPL_SET_ID 1c6c18db-5e42-4942-a611-00d49651a91f MTHSPL
SPL_SET_ID 2854d3b7-f874-4c67-8014-adda9639f515 MTHSPL
SPL_SET_ID 2c2b4ce1-2a54-4ff4-a660-14629a3df69f MTHSPL
SPL_SET_ID 2fabca6e-13a2-4c03-ad5c-50948d14c728 MTHSPL
SPL_SET_ID 32a409a0-fea6-411a-8218-c1c7df46d664 MTHSPL
SPL_SET_ID 3a5e4a8e-20bb-4bf8-8a2e-8dfd7f2afb49 MTHSPL
SPL_SET_ID 3d838426-e16d-7033-ca80-2ac14fd05730 MTHSPL
SPL_SET_ID 3d858754-b3d0-49cb-834e-9b9a35eea0fa MTHSPL
SPL_SET_ID 5419f5dd-bf20-4eea-982d-33511a022c38 MTHSPL
SPL_SET_ID 54d1720d-edfc-4eb4-8388-f61bd5971336 MTHSPL
SPL_SET_ID 62076628-fde5-434a-adab-2f83127f0e10 MTHSPL
SPL_SET_ID 65ba2f62-ddb1-48d4-84bf-e824957969af MTHSPL
SPL_SET_ID 6f363d06-2400-43be-8fe5-69246c0fdc49 MTHSPL
SPL_SET_ID 7fe5d2db-c59d-4e15-acd7-f9df8eca45aa MTHSPL
SPL_SET_ID 80c8372b-c43e-4803-889c-c9deac815339 MTHSPL
SPL_SET_ID 850d16bd-96d0-4186-8113-17d961ff18ea MTHSPL
SPL_SET_ID 9215ec6b-69df-4b7d-b426-af50955d2c7c MTHSPL
SPL_SET_ID 9b3c7b34-abd9-417b-a2e9-b7e857339ff5 MTHSPL
SPL_SET_ID a762e164-b390-4e8c-bd46-bf6c31eeb486 MTHSPL
SPL_SET_ID a9bd1172-8d70-eb18-fb94-330f8aecd8b9 MTHSPL
SPL_SET_ID ac85703a-17a2-4f0b-87f4-78f1756d2f85 MTHSPL
SPL_SET_ID b45cee2a-8d11-4fda-b8f8-e1f71abf87c6 MTHSPL
SPL_SET_ID bc723e31-99f6-40cb-94ab-1b64d359fa0d MTHSPL
SPL_SET_ID bf706448-444e-4ee5-b0a5-72a6203573bd MTHSPL
SPL_SET_ID c5f6201b-9ad2-4611-b99a-954634bfe03a MTHSPL
SPL_SET_ID c9a4c16f-2582-4bc5-9d0f-3de38d61a9dc MTHSPL
SPL_SET_ID d07410b3-37e6-4382-97de-0c2676bc1103 MTHSPL
SPL_SET_ID d733246e-9292-4cf1-bba1-672b92886805 MTHSPL
SPL_SET_ID e2a2602d-ba5c-423a-bcaf-0864883aed22 MTHSPL
SPL_SET_ID e87b9cb1-10a4-7b2b-d3c7-4fc449c6de0d MTHSPL
SPL_SET_ID eaa5b1bd-0927-46e4-b941-32fcc492d258 MTHSPL
SPL_SET_ID eaecd9a1-e13e-49b1-8b3c-8e1ef016cacd MTHSPL
SPL_SET_ID edf54a38-41a7-42ec-a05f-46ab20cb6fc3 MTHSPL
SPL_SET_ID fa423968-8b64-4096-acab-5a10a7243d24 MTHSPL
SPL_SET_ID fa8b2dd2-fe78-4b32-883d-8e1401b42822 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x02Lq SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUW19 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T040393 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^220^Active/Master NDFRT
VANDF_RECORD 50.6^118^Active/Master NDFRT
VUID 4017625 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0039644

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