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Temazepam (CUI C0039468) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0039468

NCI Thesaurus Code: C29488  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A benzodiazepine derivative with antidepressant, sedative, hypnotic and anticonvulsant properties. Temazepam potentiates the inhibitory activities of gamma-aminobutyric acid (GABA) by binding to the GABA receptor, located in the limbic, neocortical and mesencephalic reticular system. This increases the frequency of chloride channel opening events, allowing the flow of chloride ions into the neuron leading to membrane hyperpolarization and decreases neuronal excitability.

MSH Definition: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.

Synonyms & Abbreviations: (see Synonym Details)
10-chloro-4-hydroxy-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-
3 Hydroxydiazepam
3-Hydroxydiazepam
Hydroxydiazepam
Methyloxazepam
Oxydiazepam
Product containing temazepam (medicinal product)
Product containing temazepam
Ro 5 5345
Ro 5-5345
Ro-5-5345
Ro55345
Temazepam (substance)
Temazepam [Chemical/Ingredient]
temazepam

External Source Codes: 
NCI Thesaurus Code C29488 (see NCI Thesaurus info)
CAS Registry Number 846-50-4 (see NLM ChemIDplus info)
FDA UNII Code CHB1QD2QSS
NSC Code 246303 (see NCI DTP info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Chemical_Formula C16H13ClN2O2 NCI
Contributing_Source FDA NCI
CTV3ID x02Ml SNOMEDCT_US
CTV3ID XUWu8 SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DX 19910101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20030131 SNOMEDCT_US
FDA_UNII_CODE CHB1QD2QSS DRUGBANK
FDA_UNII_CODE CHB1QD2QSS NDFRT
HN 91(79); was see under BENZODIAZEPINE TRANQUILIZERS 1979-90 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19780320 MSH
MESH_DEFINITION A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent. NDFRT
MESH_DUI D013693 NDFRT
MESH_NAME Temazepam NDFRT
MESH_UI M0021137 NDFRT
MMR 20160601 MSH
MN D03.633.100.079.080.070.880 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007199 NDFRT
NUI N0000146246 NDFRT
PA D006993 MSH
PA D014151 MSH
PA D018757 MSH
PM 91; was see under BENZODIAZEPINE TRANQUILIZERS 1979-90 MSH
RN 0 MSH
RN CHB1QD2QSS MSH
RR 846-50-4 (Temazepam) MSH
RXAUI 2074727 RXNORM
RXAUI 2622733 RXNORM
RXAUI 2991065 RXNORM
RXAUI 3092867 RXNORM
RXAUI 3093231 RXNORM
RXAUI 3173985 RXNORM
RXAUI 3198544 RXNORM
RXAUI 3211498 RXNORM
RXAUI 3243806 RXNORM
RXAUI 3243807 RXNORM
RXAUI 3247539 RXNORM
RXAUI 3247540 RXNORM
RXAUI 331139 RXNORM
RXAUI 3608021 RXNORM
RXCUI 10355 RXNORM
SID APRD00676 DRUGBANK
SPL_SET_ID 09abc9b1-50fc-4c60-a6a1-9772e35b057a MTHSPL
SPL_SET_ID 09e74fd3-223b-4476-86b3-f5eeeb5af330 MTHSPL
SPL_SET_ID 19b2711e-587a-47d2-ab62-d564e7b87195 MTHSPL
SPL_SET_ID 19e1d930-20b3-81e3-0c6d-3e4979460444 MTHSPL
SPL_SET_ID 1c08d30d-7c27-a09a-5240-7050771d5cc7 MTHSPL
SPL_SET_ID 23ff2d2f-4770-4760-9b41-a850329bb2c7 MTHSPL
SPL_SET_ID 2461dfbd-5704-42f4-bde7-d1461811d898 MTHSPL
SPL_SET_ID 2c4f564d-d349-4f9b-b3f4-f3f0d9706a4d MTHSPL
SPL_SET_ID 2ed81194-be24-45a0-8dde-fbc6ad3d7abe MTHSPL
SPL_SET_ID 2fc457a3-2e5e-1e32-fe4d-ad00e15cf9e8 MTHSPL
SPL_SET_ID 30dadf97-4e8c-4630-b362-940313a8852e MTHSPL
SPL_SET_ID 3e4a35f8-77e5-4c9a-aad2-b0aeb98edd66 MTHSPL
SPL_SET_ID 40b2ff05-3d35-4cd7-a525-0f8b507ac178 MTHSPL
SPL_SET_ID 43fc3559-6482-4ff2-bd6a-40d881b3adb2 MTHSPL
SPL_SET_ID 45ef5e9c-f381-48d3-895d-e1d29be856ac MTHSPL
SPL_SET_ID 471fa2f1-73a0-49be-89f3-d3e2cfdaeca0 MTHSPL
SPL_SET_ID 47ff9717-042f-4df3-864e-3cd6ef19d33a MTHSPL
SPL_SET_ID 4ac590e9-af71-43c0-a836-b700115d7ba2 MTHSPL
SPL_SET_ID 55f28be9-7d69-467c-b5de-6e281ca9c498 MTHSPL
SPL_SET_ID 5aaf8c99-cd58-47fc-8bf5-1039a6315ca5 MTHSPL
SPL_SET_ID 5da409a5-bb7b-4881-a3d7-044b4f75d6a0 MTHSPL
SPL_SET_ID 5de3751c-66d8-4b77-8698-12b67aa5f9e8 MTHSPL
SPL_SET_ID 62379cd5-a314-43eb-a1ee-33997623bfa3 MTHSPL
SPL_SET_ID 67040aa9-3a87-4c8a-882c-4b637a69d0b6 MTHSPL
SPL_SET_ID 68e2c1d8-9d6a-44a0-86f0-ba63a3263d22 MTHSPL
SPL_SET_ID 6979644e-0587-4040-b754-5dce5eda87a4 MTHSPL
SPL_SET_ID 70aaf6b1-91c9-4a5a-82c8-3c34c4e1dfe3 MTHSPL
SPL_SET_ID 74f261c5-a960-44ef-be4c-4dcefd881c3f MTHSPL
SPL_SET_ID 7b74c9aa-cb40-4a45-abab-845ad2fa28cf MTHSPL
SPL_SET_ID 7c767b9f-5e02-475b-aaef-73944006e379 MTHSPL
SPL_SET_ID 7df11f3e-f79b-4d52-a94b-4c0a31ebfe41 MTHSPL
SPL_SET_ID 85327378-86a3-4448-9185-e20bb20ebf45 MTHSPL
SPL_SET_ID 89394e35-f134-4e47-91a5-0cbf14dbe793 MTHSPL
SPL_SET_ID 8d7dc0ae-303c-4ad3-9b76-42b5bafedb9d MTHSPL
SPL_SET_ID 8f54731f-c5b7-492c-acb0-444c5fbb7029 MTHSPL
SPL_SET_ID 904b8986-24da-48eb-bb0a-33d41b4eb005 MTHSPL
SPL_SET_ID a2a65116-b351-4833-8813-c975161dad6a MTHSPL
SPL_SET_ID a2e1a7d2-aaba-45c7-9987-61f91e96f92c MTHSPL
SPL_SET_ID a3f06243-fa03-4cbd-951a-144ec43dcdfd MTHSPL
SPL_SET_ID a4231f67-6c04-4ce6-8c3d-6db52afaadbe MTHSPL
SPL_SET_ID a4370eb4-b00d-4247-af8d-980e59fbbec6 MTHSPL
SPL_SET_ID a4a2e4e3-6213-4d72-bbdc-7c1447283e2b MTHSPL
SPL_SET_ID a4ee3907-45d4-41b9-af8a-39a9966cd533 MTHSPL
SPL_SET_ID a5416154-8490-4e84-bb6f-4ff0cc605214 MTHSPL
SPL_SET_ID abdeee37-d0d8-4f22-a977-f8ea37c51f03 MTHSPL
SPL_SET_ID aeaa1606-a75f-44ad-99de-56567fcc40dc MTHSPL
SPL_SET_ID b5b231ec-f5c4-4b2a-82f8-7b52396cb84f MTHSPL
SPL_SET_ID b9d4ff6b-4e36-4530-8b67-4403ed2d357e MTHSPL
SPL_SET_ID bc56f7fd-1aaf-48ff-8aa7-d467e59e1015 MTHSPL
SPL_SET_ID bcfd6a3d-66eb-4844-bede-6ec671985b2c MTHSPL
SPL_SET_ID bd196d0b-9ab4-4ffc-9ca4-f0bf96f98715 MTHSPL
SPL_SET_ID becd63c1-5d14-4578-9f1e-df583f18a818 MTHSPL
SPL_SET_ID c270129a-03e8-4c3d-a47e-0e533f05b2ad MTHSPL
SPL_SET_ID c9bc61b4-a579-4003-98da-b6f6e381c150 MTHSPL
SPL_SET_ID ce2748a3-72ab-407a-ac63-86ce1a126e18 MTHSPL
SPL_SET_ID d4a241c7-a4de-4f6b-b831-e063cf8c3d54 MTHSPL
SPL_SET_ID dbd39517-62f5-44b0-844f-e1cbf3c6ca2e MTHSPL
SPL_SET_ID eeb9df6c-e8a7-470e-99d4-9c0495554720 MTHSPL
SPL_SET_ID f0f4184e-e7e1-49e6-9b93-ac599ac524c6 MTHSPL
SPL_SET_ID f1ff672d-0b95-4e1b-9104-a545e02f4ee7 MTHSPL
SPL_SET_ID f7c31cab-c96b-45e1-8c29-48e17b3fd731 MTHSPL
SPL_SET_ID fe3a8ab5-8603-4d8e-922c-7a41fbb815a5 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x02Ml SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWu8 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T040240 MSH
TERMUI T040241 MSH
TERMUI T040242 MSH
TERMUI T040243 MSH
TERMUI T040244 MSH
TERMUI T040246 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH UNK (19XX) MSH
TH USAN (1969) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^489^Active/Master NDFRT
VANDF_RECORD 50.6^244^Active/Master NDFRT
VUID 4017894 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0039468

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