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Tamoxifen (CUI C0039286) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0039286

NCI Thesaurus Code: C62078  (see NCI Thesaurus info)

Semantic Type: Organic Chemical

Semantic Type: Pharmacologic Substance

NCIt Definition: An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth.

NCI-GLOSS Definition: A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen is a type of antiestrogen.

CSP Definition: selective estrogen receptor modulator; it is agonist for bone tissue and cholesterol metabolism but antagonist in mammary and uterine tissues.

MSH Definition: One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.

NPO Definition: Tamoxifen is an organic compound, which has a parent hydride, stilbin; and which blocks the effects of the hormone estrogen in the body. It is used to prevent or delay the return of breast cancer or to control its spread.

Synonyms & Abbreviations: (see Synonym Details)
(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine
(Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine
(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-P-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
1-Para-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene
Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, (Z)-
Product containing tamoxifen (medicinal product)
Product containing tamoxifen
Tamoxifen (substance)
Tamoxifen [Chemical/Ingredient]
Tamoxifene
Tamoxifeno
Tamoxifenum
tamoxifen
Tamoxifène
TAM
TMX

External Source Codes: 
NCI Thesaurus Code C62078 (see NCI Thesaurus info)
CAS Registry Number 10540-29-1 (see NLM ChemIDplus info)
FDA UNII Code 094ZI81Y45

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
ANSWER_CODE 1 LNC
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:41774 NCI
Chemical_Formula C26H29NO NCI
CODE NPO_254 NPO
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID he4.. SNOMEDCT_US
CTV3ID XUWGx SNOMEDCT_US
DB_XR_ID CHEBI:41774 NPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0119-1179 CSP
DX 19780101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
FDA_UNII_CODE 094ZI81Y45 DRUGBANK
FDA_UNII_CODE 094ZI81Y45 NDFRT
HN 78(75); was see under STILBENES 1975-77 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19741111 MSH
MESH_DEFINITION One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. NDFRT
MESH_DUI D013629 NDFRT
MESH_NAME Tamoxifen NDFRT
MESH_UI M0021024 NDFRT
MMR 20160701 MSH
MN D02.455.426.559.389.150.700.900 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000007041 NDFRT
NUI N0000148024 NDFRT
PA D004965 MSH
PA D018931 MSH
PA D020845 MSH
PA D050071 MSH
PM 78; was see under STILBENES 1975-77 MSH
RDF_ID CHEBI_41774 NPO
RN 094ZI81Y45 MSH
RR 10540-29-1 (Tamoxifen) MSH
RR 54965-24-1 (citrate) MSH
RR 7FRV7310N6 MSH
RXAUI 2074640 RXNORM
RXAUI 3155724 RXNORM
RXAUI 3243532 RXNORM
RXAUI 3243533 RXNORM
RXAUI 3247225 RXNORM
RXAUI 3247228 RXNORM
RXAUI 330171 RXNORM
RXAUI 6395932 RXNORM
RXAUI 6395995 RXNORM
RXCUI 10324 RXNORM
SID APRD00123 DRUGBANK
SOS modifies expression of specific genes NPO
SPL_SET_ID 063FA789-4570-4715-C3BD-1BAD0449FB26 MTHSPL
SPL_SET_ID 151ce76c-2d44-4c82-850d-ab213bea4d6b MTHSPL
SPL_SET_ID 2720c127-ec86-42ea-97e7-88dd6a195cdb MTHSPL
SPL_SET_ID 407a372d-4448-4d53-afd4-eb0e74bbc336 MTHSPL
SPL_SET_ID 410319e0-5f3e-425c-b4b6-7b9e6cf5884f MTHSPL
SPL_SET_ID 61c988cc-a5bf-4cd2-81fd-4442a940622f MTHSPL
SPL_SET_ID 7ee3d3d2-85d1-4018-8e70-5ed8a64ae1f0 MTHSPL
SPL_SET_ID 86dcde0e-347c-49e1-8b38-ad106a25c9af MTHSPL
SPL_SET_ID 8d731e7e-3b04-49a2-a0f6-3779422174cc MTHSPL
SPL_SET_ID 8e02d45c-2b87-4c2f-8d75-b848172fafde MTHSPL
SPL_SET_ID 8e4710a7-8757-49be-8bec-a1dc39e6c695 MTHSPL
SPL_SET_ID 8f642753-9e12-433c-a0bc-ab33dac41ddf MTHSPL
SPL_SET_ID 9b8a4211-120f-4981-ad69-928accb97637 MTHSPL
SPL_SET_ID d5f46219-26f3-4d48-b8d8-4204af5d4e36 MTHSPL
SPL_SET_ID dc7bcc53-b69d-48dc-aa5e-b0454d6aa210 MTHSPL
SPL_SET_ID f5ffe9dd-f76d-4aab-9473-81e33b26710b MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~he4.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUWGx SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T040032 MSH
TH BAN (19XX) MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1978) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
UI1_HAS_ROLE payload agent role~NPO_635 NPO
VANDF_RECORD 50.416^2565^Active/Master NDFRT
VANDF_RECORD 50.6^772^Active/Master NDFRT
VUID 4019939 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0039286

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