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Succinylcholine (CUI C0038627) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0038627

NCI Thesaurus Code: C61955  (see NCI Thesaurus info)

Semantic Type: Pharmacologic Substance

Semantic Type: Organic Chemical

NCIt Definition: A quaternary ammonium compound and depolarizing agent with short-term muscle relaxant properties. Succinylcholine binds to nicotinic receptors at the neuromuscular junction and opening the ligand-gated channels in the same way as acetylcholine, resulting in depolarization and inhibition of neuromuscular transmission. Depolarization may be prolonged due to succinylcholine's resistance to acetylcholinesterases thereby leading to disorganized muscle contraction followed by skeletal muscle relaxation and flaccid paralysis.

MSH Definition: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.

Synonyms & Abbreviations: (see Synonym Details)
2,2'-[(1,4-DIOXOBUTANE-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
Dicholine succinate
Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl)-
Product containing succinylcholine (medicinal product)
Product containing succinylcholine
Succinic acid, diester with choline
Succinocholine
Succinoylcholine
Succinylbischoline
Succinylcholine (substance)
Succinylcholine [Chemical/Ingredient]
succinylcholine
Succinyldicholine
Suxamethonium

External Source Codes: 
NCI Thesaurus Code C61955 (see NCI Thesaurus info)
CAS Registry Number 306-40-1 (see NLM ChemIDplus info)
FDA UNII Code J2R869A8YF

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BL CF CH CL CS CT EC HI IM IP ME PD PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:45652 NCI
Chemical_Formula C14H30N2O4 NCI
Contributing_Source FDA NCI
CTV3ID o69.. SNOMEDCT_US
CTV3ID XUVzk SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0663-0420 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20020731 SNOMEDCT_US
FDA_UNII_CODE J2R869A8YF DRUGBANK
FDA_UNII_CODE J2R869A8YF NDFRT
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. NDFRT
MESH_DUI D013390 NDFRT
MESH_NAME Succinylcholine NDFRT
MESH_UI M0020712 NDFRT
MMR 20130708 MSH
MN D02.092.877.883.333.780 MSH
MN D02.241.081.337.759.875 MSH
MN D02.675.276.232.780 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006153 NDFRT
NUI N0000148020 NDFRT
PA D009467 MSH
RN J2R869A8YF MSH
RR 1MBL83KX8J MSH
RR 23487-14-1 (diperchlorate) MSH
RR 306-40-1 (Succinylcholine) MSH
RR 541-19-5 (diiodide) MSH
RR 55-94-7 (dibromide) MSH
RR 6101-15-1 (dichloride, di-H2O) MSH
RR 71-27-2 (dichloride) MSH
RR I9L0DDD30I MSH
RXAUI 2074517 RXNORM
RXAUI 3155735 RXNORM
RXAUI 3235681 RXNORM
RXAUI 3235682 RXNORM
RXAUI 3241221 RXNORM
RXAUI 3241223 RXNORM
RXAUI 3241227 RXNORM
RXAUI 3241827 RXNORM
RXAUI 325056 RXNORM
RXAUI 6395906 RXNORM
RXCUI 10154 RXNORM
SID APRD00159 DRUGBANK
SPL_SET_ID 579ff759-3099-45f5-befe-c4b79106c87e MTHSPL
SPL_SET_ID c06156ae-b889-4250-bc85-1435b2635829 MTHSPL
SPL_SET_ID d1c0c9d3-f2c0-4199-87f1-8fade79d6a85 MTHSPL
SPL_SET_ID fb08161e-7711-406d-e7b3-ea4515c07983 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~o69.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XUVzk SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T039298 MSH
TERMUI T039299 MSH
TERMUI T039300 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^2560^Active/Master NDFRT
VANDF_RECORD 50.6^125^Active/Master NDFRT
VUID 4019935 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0038627

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