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Ankylosing spondylitis (CUI C0038013) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0038013

NCI Thesaurus Code: C84564  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

RADLEX Definition: The form of rheumatoid arthritis affecting the spine. It occurs predominantly in young males and produces pain and stiffness as a result of inflammation of the sacroiliac, intervertebral, and costovertebral joints. Etiology is unknown. [MeSH]

GARD Definition: Ankylosing spondylitis (AS) is a type of chronic inflammatory arthritis that mainly affects the spine. It usually begins with inflammation of the joints between the pelvic bones and spine, gradually spreading to the joints between the vertebrae. Signs and symptoms usually begin in adolescence or early adulthood and may include back pain and stiffness. Back movement gradually becomes more limited as the vertebrae fuse together. The condition may also affect the shoulders; ribs; hips; knees; and feet; as well as the eyes; bowel; and very rarely, the heart and lungs. AS is likely caused by a combination of genetic and environmental factors; variations in several genes are thought to affect the risk to develop AS. In most cases, treatment involves exercise and medications to relieve pain and inflammation. - this information is from GARD/ORDR/NCATS.

MEDLINEPLUS Definition: 

Ankylosing spondylitis is a type of arthritis of the spine. It causes inflammation between your vertebrae, which are the bones that make up your spine, and in the joints between your spine and pelvis. In some people, it can affect other joints.

AS is more common and more severe in men. It often runs in families. The cause is unknown, but it is likely that both genes and factors in the environment play a role.

Early symptoms of AS include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, AS can fuse your vertebrae together, limiting movement. Some people have symptoms that come and go. Others have severe, ongoing pain.

A diagnosis of AS is based on your medical history and a physical examination. You may also have imaging or blood tests.

AS has no cure, but medicines can relieve symptoms and may keep the disease from getting worse. Eating a healthy diet, not smoking, and exercising can also help. In rare cases, you may need surgery to straighten the spine.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Disease

NICHD Definition: An immune-mediated disease characterized by inflammation in the axial skeleton including sacroiliac joints, vertebrae and vertebral joints. Peripheral joints may be involved as well. Clinical features can include low back pain and stiffness, limited motion of the lumbar spine, and limited chest expansion.

MSH Definition: A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.

Synonyms & Abbreviations: (see Synonym Details)
Ank spond
Ankylosing Spondylarthritides
Ankylosing Spondylarthritis
Ankylosing spondylitis (disorder)
ankylosing spondylitis
Ankylosing Spondyloarthritides
Ankylosing spondyloarthritis
AS - Ankylosing spondylitis
Bechterew Disease
BECHTEREW DIS
Bechterew's disease
Bechterews Disease
BECHTEREWS DIS
Bekhterev's disease
Idiopathic ankylosing spondylitis
Marie Struempell Disease
MARIE STRUEMPELL DIS
MARIE STRUMPELL DISEASE
Marie Strümpell spondylitis
Marie-Struempell Disease
MARIE-STRUEMPELL SPONDYLITIS
Marie-Strumpell spondylitis
Rheumatioid arthritis of spine NOS
Rheumatoid arthritis of spine
Rheumatoid Spondylitis
Spondylarthritides, Ankylosing
Spondylarthritis Ankylopoietica
Spondylarthritis, Ankylosing
Spondylitis ankylopoietica
Spondylitis ankylosans
Spondylitis ankylosing
Spondylitis, Ankylosing [Disease/Finding]
SPONDYLITIS, ANKYLOSING
Spondylitis, Marie-Strumpell
SPONDYLITIS, RHEUMATOID
Spondyloarthritides, Ankylosing
Spondyloarthritis Ankylopoietica
Spondyloarthritis, Ankylosing
VON BECHTEREW-STRUEMPELL SYNDROME

External Source Codes: 
NCI Thesaurus Code C84564 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN coordinate with specific vertebra MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID N100. SNOMEDCT_US
DATE_CREATED 07/08/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2715-1392 CSP
DID 2715-3112 CSP
DID 5006-0035 CSP
DISEASE_IDENTIFIER_ID 2401 GARD
DX 19660101 MSH
EFFECTIVE_TIME 20040731 SNOMEDCT_US
EXCLUDES1 arthropathy in Reiter's disease (M02.3-) ICD10CM
EXCLUDES1 juvenile (ankylosing) spondylitis (M08.1) ICD10CM
EXCLUDES2 Behçet's disease (M35.2) ICD10CM
HAS_GARD_PAGE true GARD
IAN DEFAULT ICD10
ICE Rheumatioid arthritis of spine NOS; Spondylitis: {Marie-Strumpell; rheumatoid} ICD9CM
IDENTIFIER_TYPE_ID 1 GARD
INCLUSION_TERM Rheumatoid arthritis of spine ICD10
IS_ACTIVE true GARD
IS_RARE false GARD
IS_SPANISH false GARD
LAST_REVIEW_ACTION Synonym Added GARD
MDA 19990101 MSH
MESH_DEFINITION A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions. NDFRT
MESH_DUI D013167 NDFRT
MESH_NAME Spondylitis, Ankylosing NDFRT
MESH_UI M0020377 NDFRT
MMR 20130708 MSH
MN C05.116.900.853.625.800.850 MSH
MN C05.550.069.680 MSH
MN C05.550.114.865.800.850 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/ankylosingspondylitis.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/ankylosingspondylitis.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Arthritis and Musculoskeletal and Skin Diseases http://www.niams.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Ankylosing Spondylitis NCI
NUI N0000002810 NDFRT
ORDER_NO 18198 ICD10CM
PRIMARY_PATH 10002556$10052775$10023213$10028395$Ankylosing spondylitis$Spondyloarthropathies$Joint disorders$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/9518/ankylosing-spondylitis/resources/1 GARD
RXAUI 3109420 RXNORM
RXAUI 3116780 RXNORM
RXAUI 3116781 RXNORM
RXAUI 3196703 RXNORM
RXAUI 3232178 RXNORM
RXAUI 3239917 RXNORM
RXAUI 3239929 RXNORM
RXAUI 3239930 RXNORM
RXAUI 3286694 RXNORM
RXAUI 3286695 RXNORM
RXAUI 5932302 RXNORM
RXAUI 5932303 RXNORM
RXCUI 990551 RXNORM
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 16.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 9631008 NDFRT
SNOMEDID D1-23110 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS M45.X9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~M45.X9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M45.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BETWEEN 1.0 YEAR AND 18.0 YEARS CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLARTHRITIS AND EYE LESIONS AND IF AGE AT ONSET OF CLINICAL FINDING BETWEEN 1.0 YEAR AND 18.0 YEARS CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLARTHRITIS AND EYE LESIONS CHOOSE H57.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLARTHRITIS AND EYE LESIONS CHOOSE M45.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLITIS WITH MULTISYSTEM INVOLVEMENT AND IF AGE AT ONSET OF CLINICAL FINDING BETWEEN 1.0 YEAR AND 18.0 YEARS CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLITIS WITH MULTISYSTEM INVOLVEMENT CHOOSE M45.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLITIS WITH ORGAN / SYSTEM INVOLVEMENT AND IF AGE AT ONSET OF CLINICAL FINDING BETWEEN 1.0 YEAR AND 18.0 YEARS CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ANKYLOSING SPONDYLITIS WITH ORGAN / SYSTEM INVOLVEMENT CHOOSE M45.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF JUVENILE ANKYLOSING SPONDYLITIS CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF JUVENILE SPONDYLOARTHROPATHY CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ON EXAMINATION - ANKYLOSING SPONDYLITIS CHEST DEFORMITY AND IF AGE AT ONSET OF CLINICAL FINDING BETWEEN 1.0 YEAR AND 18.0 YEARS CHOOSE M08.1 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ON EXAMINATION - ANKYLOSING SPONDYLITIS CHEST DEFORMITY CHOOSE M45.4 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ON EXAMINATION - ANKYLOSING SPONDYLITIS CHEST DEFORMITY CHOOSE M95.4 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~10 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~11 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~12 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~5 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~6 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~8 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 129564003 | Ankylosing spondylarthritis and eye lesions (disorder) | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | >= 1.0 year AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 129564003 | Ankylosing spondylarthritis and eye lesions (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 162930007 | On examination - ankylosing spondylitis chest deformity (disorder) | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | >= 1.0 year AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 162930007 | On examination - ankylosing spondylitis chest deformity (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 239805001 | Juvenile ankylosing spondylitis (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 239806000 | Juvenile spondyloarthropathy (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 239810002 | Ankylosing spondylitis with organ / system involvement (disorder) | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | >= 1.0 year AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 239810002 | Ankylosing spondylitis with organ / system involvement (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 239811003 | Ankylosing spondylitis with multisystem involvement (disorder) | AND IFA 445518008 | Age at onset of clinical finding (observable entity) | >= 1.0 year AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 239811003 | Ankylosing spondylitis with multisystem involvement (disorder) | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | >= 1.0 year AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~H57.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M08.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M45.4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M45.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M95.4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~N100. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D1-23110 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T038688 MSH
TERMUI T038689 MSH
TERMUI T038690 MSH
TERMUI T038691 MSH
TERMUI T038692 MSH
TERMUI T038693 MSH
TERMUI T684744 MSH
TERMUI T751407 MSH
TERMUI T751408 MSH
TERMUI T840911 MSH
TERMUI T840912 MSH
TH GHR (2014) MSH
TH NLM (1966) MSH
TH NLM (1993) MSH
TH NLM (2008) MSH
TH NLM (2010) MSH
TH ORD (2010) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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