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Smallpox (CUI C0037354) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0037354

NCI Thesaurus Code: C35027  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: A condition that is caused by infection with Variola, and that is characterized by small, raised bumps.

MEDLINEPLUS Definition: 

Smallpox is a disease caused by the Variola major virus. Some experts say that over the centuries it has killed more people than all other infectious diseases combined. Worldwide immunization stopped the spread of smallpox three decades ago. The last case was reported in 1977. Two research labs still keep small amounts of the virus. Experts fear bioterrorists could use the virus to spread disease.

Smallpox spreads very easily from person to person. Symptoms are flu-like. They include

  • High fever
  • Fatigue
  • Headache
  • Backache
  • A rash with flat red sores

There is no treatment. Fluids and medicines for pain or fever can help control symptoms. Most people recover, but some can die. Those who do recover may have severe scars.

The U.S. stopped routine smallpox vaccinations in 1972. Military and other high-risk groups continue to get the vaccine. The U.S. has increased its supply of the vaccine in recent years. The vaccine makes some people sick, so doctors save it for those at highest risk of disease.

NIH: National Institute of Allergy and Infectious Diseases

NICHD Definition: An infection that is caused by one of two viruses: Variola major or Variola minor, both of which are transmitted via inhalation of droplets. A vaccine was developed, and smallpox was declared eradicated by the WHO in 1979.

MSH Definition: An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed)

Synonyms & Abbreviations: (see Synonym Details)
Small pox
Smallpox (disorder)
Smallpox [Disease/Finding]
Smallpox NOS
Smallpox, unspecified
smallpox
Variolas
variola

External Source Codes: 
NCI Thesaurus Code C35027 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN caused by a poxvirus MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID A50.. SNOMEDCT_US
DATE_CREATED 10/18/2001 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_CREATED 2015-01-22T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3100-0734 CSP
DISEASE_IDENTIFIER_ID 33067 GARD
DISEASE_IDENTIFIER_ID 33068 GARD
DISEASE_IDENTIFIER_ID 5469 GARD
DX 19600101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN ALASTRIM was heading 1975-96 (see under SMALLPOX 1975-90); VARIOLA MINOR was see ALASTRIM 1979-96 MSH
IAN DEFAULT ICD10
IDENTIFIER_SOURCE Orp GARD
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
MDA 19990101 MSH
MESH_DEFINITION An acute, highly contagious, often fatal infectious disease caused by an orthopoxvirus characterized by a biphasic febrile course and distinctive progressive skin eruptions. Vaccination has succeeded in eradicating smallpox worldwide. (Dorland, 28th ed) NDFRT
MESH_DUI D012899 NDFRT
MESH_NAME Smallpox NDFRT
MESH_UI M0019977 NDFRT
MMR 20020702 MSH
MN C02.256.743.826 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/smallpox.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Amharic https://www.nlm.nih.gov/medlineplus/languages/smallpox.html#Amharic MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Hmong https://www.nlm.nih.gov/medlineplus/languages/smallpox.html#Hmong MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Khmer https://www.nlm.nih.gov/medlineplus/languages/smallpox.html#Khmer MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Russian https://www.nlm.nih.gov/medlineplus/languages/smallpox.html#Russian MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Somali https://www.nlm.nih.gov/medlineplus/languages/smallpox.html#Somali MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/smallpox.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Vietnamese https://www.nlm.nih.gov/medlineplus/languages/smallpox.html#Vietnamese MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Smallpox NCI
NUI N0000002776 NDFRT
ORDER_NO 00737 ICD10CM
PM ALASTRIM was heading 1975-96 (see under SMALLPOX 1975-90); VARIOLA MINOR was see ALASTRIM 1979-96 MSH
PRIMARY_PATH 10041197$10067228$10047438$10021881$Smallpox$Orthopox viral infections$Viral infectious disorders$Infections and infestations MDR
PRIMARY_SOC 10021881 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7444/smallpox/resources/1 GARD
RXAUI 3238922 RXNORM
RXAUI 3238925 RXNORM
RXAUI 3254694 RXNORM
RXCUI 1022209 RXNORM
SNOMED_CID 47452006 NDFRT
SNOMED_CID 67924001 NDFRT
SNOMEDID DE-31440 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS B03 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~B03 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS B03 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~B03 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~A50.. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DE-31440 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T038018 MSH
TERMUI T038019 MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0037354

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