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Selenium (CUI C0036581) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0036581

NCI Thesaurus Code: C825  (see NCI Thesaurus info)

Semantic Type: Biologically Active Substance

Semantic Type: Element, Ion, or Isotope

NCIt Definition: A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C.

RADLEX Definition: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of glutathione peroxidase. [MeSH]

PDQ Definition: A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C. Check for active clinical trials using this agent. (NCI Thesaurus)

NCI-GLOSS Definition: A mineral that is needed by the body to stay healthy. It is being studied in the prevention and treatment of some types of cancer. Selenium is a type of antioxidant.

CSP Definition: element with the atomic symbol Se, atomic number 34; an essential micronutrient for mammals and other animals but toxic in large amounts; protects intracellular structures against oxidative damage.

MSH Definition: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.

NPO Definition: An element with atomic number 34.

Synonyms & Abbreviations: (see Synonym Details)
7782-49-2
Minerals - Selenium
Product containing selenium (medicinal product)
Product containing selenium
Se - Selenium
Se element
Selenium (substance)
Selenium [Chemical/Ingredient]
Selenium product
selenium
Selen
Se

External Source Codes: 
NCI Thesaurus Code C825 (see NCI Thesaurus info)
CAS Registry Number 7782-49-2 (see NLM ChemIDplus info)
FDA UNII Code H6241UJ22B
PDQ Closed Trial Search ID 38725
PDQ Open Trial Search ID 38725 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
Accepted_Therapeutic_Use_For Dandruff; Psoriasis; Seborrheic dermatitis; Tinea capitis; Tinea versicolor NCI
ACTIVE 1 SNOMEDCT_US
AN Se-80; Se-74, 76-78, 82 = SELENIUM (IM) + ISOTOPES (NIM); Se-70-73, 75, 79, 81, 83-85 = SELENIUM RADIOISOTOPES (IM) MSH
AQL AD AE AG AN BL CF CH CL CT DF EC HI IM IP ME PD PH PK PO RE SD ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:27568 NCI
CHEBI_ID CHEBI:36904 NCI
Chemical_Formula Se NCI
CODE NPO_948 NPO
COMMENT Period4, Group=16, Z=34 RADLEX
Contributing_Source CTRP NCI
Contributing_Source FDA NCI
CTV3ID x01Fn SNOMEDCT_US
CTV3ID X7987 SNOMEDCT_US
DATE_LAST_MODIFIED 2006-10-02 PDQ
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 1852-9448 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20160131 SNOMEDCT_US
FDA_UNII_CODE H6241UJ22B NDFRT
FX D012644 MSH
LEVEL Example Part D Eligible Drugs USPMG
LEVEL Ingredient NDFRT
MDA 19990101 MSH
MESH_DEFINITION An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE. NDFRT
MESH_DUI D012643 NDFRT
MESH_NAME Selenium NDFRT
MESH_UI M0019604 NDFRT
MMR 20130708 MSH
MN D01.268.185.850 MSH
MN D01.578.700 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NCI_THESAURUS_CODE C825 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000006104 NDFRT
NUI N0000148196 NDFRT
ORIG_STY Drug/agent PDQ
PA D000975 MSH
PA D014131 MSH
PID 1153 PDQ
RDF_ID NPO_948 NPO
RN H6241UJ22B MSH
RR 7782-49-2 (Selenium) MSH
RXAUI 2074238 RXNORM
RXAUI 309226 RXNORM
RXAUI 3233515 RXNORM
RXAUI 3233516 RXNORM
RXAUI 3237337 RXNORM
RXAUI 3237343 RXNORM
RXAUI 3265415 RXNORM
RXAUI 3280164 RXNORM
RXAUI 6396443 RXNORM
RXCUI 9641 RXNORM
RXN_ACTIVATED 01/28/2010 RXNORM
RXN_OBSOLETED 07/02/2009 RXNORM
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SPL_SET_ID fbc6e9cb-79b2-43cb-bd4f-2076fe6ab286 MTHSPL
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SPL_SET_ID fd6d7db6-ccbd-4e4c-bee4-0a4777b476e2 MTHSPL
SPL_SET_ID fd6f19ca-4f2b-464f-89fd-97834239886b MTHSPL
SPL_SET_ID fdc9c733-2a03-44f4-9df2-c1f520fd0ff1 MTHSPL
SPL_SET_ID fde5a20d-f5ac-4522-a51a-4cbdeb4d72a2 MTHSPL
SPL_SET_ID ff696389-bad5-463a-be99-e92e86250e86 MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~x01Fn SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X7987 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T037425 MSH
TH FDA SRS (2014) MSH
TH NLM (1966) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
VANDF_RECORD 50.416^3036^Active/Master NDFRT
VANDF_RECORD 50.6^525^Active/Master NDFRT
VUID 4020392 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0036581

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