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Schizophrenia (CUI C0036341) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0036341

NCI Thesaurus Code: C3362  (see NCI Thesaurus info)

Semantic Type: Mental or Behavioral Dysfunction

NCIt Definition: A major psychotic disorder characterized by abnormalities in the perception or expression of reality. It affects the cognitive and psychomotor functions. Common clinical signs and symptoms include delusions, hallucinations, disorganized thinking, and retreat from reality.

MEDLINEPLUS Definition: 

Schizophrenia is a serious brain illness. People who have it may hear voices that aren't there. They may think other people are trying to hurt them. Sometimes they don't make sense when they talk. The disorder makes it hard for them to keep a job or take care of themselves.

Symptoms of schizophrenia usually start between ages 16 and 30. Men often develop symptoms at a younger age than women. People usually do not get schizophrenia after age 45. There are three types of symptoms:

  • Psychotic symptoms distort a person's thinking. These include hallucinations (hearing or seeing things that are not there), delusions (beliefs that are not true), trouble organizing thoughts, and strange movements.
  • "Negative" symptoms make it difficult to show emotions and to function normally. A person may seem depressed and withdrawn.
  • Cognitive symptoms affect the thought process. These include trouble using information, making decisions, and paying attention.

No one is sure what causes schizophrenia. Your genes, environment, and brain chemistry may play a role.

There is no cure. Medicine can help control many of the symptoms. You may need to try different medicines to see which works best. You should stay on your medicine for as long as your doctor recommends. Additional treatments can help you deal with your illness from day to day. These include therapy, family education, rehabilitation, and skills training.

NIH: National Institute of Mental Health

HPO Definition: A mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3-0.7%. [HPO:sdoelken]

NCI-GLOSS Definition: A group of severe mental disorders in which a person has trouble telling the difference between real and unreal experiences, thinking logically, having normal emotional responses to others, and behaving normally in social situations. Symptoms include seeing, hearing, feeling things that are not there, having false ideas about what is taking place or who one is, nonsense speech, unusual behavior, lack of emotion, and social withdrawal.

CSP Definition: class of psychoses with disturbance mainly of cognition (content and form of thought, perception, sense of self versus external world, volition) and psychomotor function, rather than affect.

MSH Definition: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.

Synonyms & Abbreviations: (see Synonym Details)
-- Schizophrenia
dementia praecox
Disorder, Schizophrenic
Disorders, Schizophrenic
Schizophrenia (disorder)
Schizophrenia [Disease/Finding]
Schizophrenia all types
Schizophrenia NOS-unspec
Schizophrenia NOS
Schizophrenia, unspecified
Schizophrenias
schizophrenia
Schizophrenic disorders (disorder)
schizophrenic disorders
Schizophrenic Disorder
SCHIZOPHRENIC DIS
SCZD
Unspecified schizophrenia, unspecified state
Unspecified schizophrenia, unspecified
unspecified schizophrenia

External Source Codes: 
NCI Thesaurus Code C3362 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN general or unspecified; prefer specifics MSH
AQL BL CF CI CL CO DG DH DI DT EC EH EN EP ET GE HI IM ME MI MO NU PA PC PP PS RH SU TH UR VI MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CTV3ID E10.. SNOMEDCT_US
CTV3ID Eu20. SNOMEDCT_US
DATE_CREATED 11/20/1998 MEDLINEPLUS
DATE_CREATED 2011-06-07T09:53:08Z HPO
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 2485-0932 CSP
DX 19660101 MSH
EC psychology:Schizophrenic Psychology MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EXCLUDES1 brief psychotic disorder (F23) ICD10CM
EXCLUDES1 cyclic schizophrenia (F25.0) ICD10CM
EXCLUDES1 mood [affective] disorders with psychotic symptoms (F30.2, F31.2, F31.5, F31.64, F32.3, F33.3) ICD10CM
EXCLUDES1 schizoaffective disorder (F25.-) ICD10CM
EXCLUDES1 schizophrenic reaction NOS (F23) ICD10CM
EXCLUDES2 alcoholism (F10.15-, F10.25-, F10.95-) ICD10CM
EXCLUDES2 brain disease (F06.2) ICD10CM
EXCLUDES2 epilepsy (F06.2) ICD10CM
EXCLUDES2 psychoactive drug use (F11-F19 with .15. .25, .95) ICD10CM
EXCLUDES2 schizophrenic reaction in: ICD10CM
EXCLUDES2 schizotypal disorder (F21) ICD10CM
EXTERNALLY_DEFINED N LNC
GENELOCUS ,1,p,3,6,.,2, OMIM
GENESYMBOL SCZD12 OMIM
HPO_COMMENT Positive symptoms, such as delusions and hallucinations (especially of voices), are common, and any Schneiderian first-rank symptoms are particularly indicative of the illness. Negative symptoms include social withdrawal, impairment of ego boundaries, and loss of energy and initiative. Schizophrenia is diagnosed only if symptoms persist for at least one month. The illness can spontaneously remit, run a course with infrequent or frequent relapses, or become chronic. The prognosis has improved with antipsychotic drugs and with vigorous psychological and social management and rehabilitation. The many causes include genetic factors, environmental stress, and various triggering factors. HPO
IAN DEFAULT ICD10
ICE Schizophrenia: {NOS; mixed NOS; undifferentiated NOS}; Schizophrenic reaction NOS; Schizophreniform psychosis NOS ICD9CM
ICF The following fifth-digit subclassification is for use with category 295: {0 unspecified; 1 subchronic; 2 chronic; 3 subchronic with acute exacerbation; 4 chronic with acute exacerbation; 5 in remission} ICD9CM
IPX -F20 ICPC
IPX -F21 ICPC
IPX -F22 ICPC
IPX -F23 ICPC
IPX -F24 ICPC
IPX -F25 ICPC
IPX -F28 ICPC
IPX -F29 ICPC
MDA 19990101 MSH
MESH_DEFINITION A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. NDFRT
MESH_DUI D012559 NDFRT
MESH_NAME Schizophrenia NDFRT
MESH_UI M0019489 NDFRT
MIMTYPE 3 OMIM
MIMTYPEMEANING Phenotype description, molecular basis known. OMIM
MIMTYPEVALUE pound OMIM
MMR 20120703 MSH
MN F03.700.750 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/schizophrenia.html MEDLINEPLUS
MP_OTHER_LANGUAGE_URL Spanish https://www.nlm.nih.gov/medlineplus/spanish/schizophrenia.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Mental Health http://www.nimh.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NUI N0000002690 NDFRT
ORDER_NO 05390 ICD10CM
ORDER_NO 05399 ICD10CM
PRIMARY_PATH 10039626$10039631$10039628$10037175$Schizophrenia$Schizophrenia NEC$Schizophrenia and other psychotic disorders$Psychiatric disorders MDR
PRIMARY_SOC 10037175 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RXAUI 3145409 RXNORM
RXAUI 3236754 RXNORM
RXAUI 3236755 RXNORM
RXAUI 3236784 RXNORM
RXCUI 1022169 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 191526005 NDFRT
SNOMED_CID 191528006 NDFRT
SNOMED_CID 58214004 NDFRT
SNOMEDID D9-40000 SNOMEDCT_US
SNOMEDID D9-40005 SNOMEDCT_US
SOS Excludes: childhood type schizophrenia (299.9); infantile autism (299.0) ICD9CM
SOS Includes: schizophrenia of the types described in 295.0-295.9 occurring in children ICD9CM
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS F20.9 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~F20.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS F20.9 | DESCENDANTS NOT EXHAUSTIVELY MAPPED SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS F20.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 18.0 YEARS CHOOSE F84.5 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | DESCENDANTS NOT EXHAUSTIVELY MAPPED | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING BEFORE 18.0 YEARS CHOOSE F84.5 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F20.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~F84.5 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~E10.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~Eu20. SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D9-40000 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~D9-40005 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
TERMUI T037216 MSH
TERMUI T037217 MSH
TERMUI T037218 MSH
TH BIOETHICS (1974) MSH
TH OMIM (2013) MSH
TH UNK (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

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