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Riboflavin (CUI C0035527) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0035527

NCI Thesaurus Code: C808  (see NCI Thesaurus info)

Semantic Type: Vitamin

Semantic Type: Pharmacologic Substance

NCIt Definition: An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair.

PDQ Definition: An essential human nutrient that is a heat-stable and water-soluble flavin belonging to the vitamin B family. Riboflavin is a precursor of the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes are of vital importance in normal tissue respiration, pyridoxine activation, tryptophan to niacin conversion, fat, carbohydrate, and protein metabolism, and glutathione reductase mediated detoxification. Riboflavin may also be involved in maintaining erythrocyte integrity. This vitamin is essential for healthy skin, nails, and hair. Check for active clinical trials using this agent. (NCI Thesaurus)

CRCH Definition: Water-soluble vitamin that is a coenzyme in numerous oxidation-reduction reactions. (DRI)

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Riboflavin helps make red blood cells, helps some enzymes work properly, and keeps skin, nails, and hair healthy. It is found in milk, eggs, malted barley, organ meats, yeast, and leafy vegetables. Riboflavin is water-soluble (can dissolve in water) and must be taken in every day. Not enough riboflavin can cause anemia (a low number of red blood cells), mouth sores, and skin problems. Amounts of riboflavin may be higher in the blood of patients with some types of cancer.

CSP Definition: water soluble B vitamin; precursor of FMN and FAD.

MSH Definition: Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.

Synonyms & Abbreviations: (see Synonym Details)
1-Deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)pentitol
33298
6,7-Dimethyl-9-D-ribitylisoalloxazine
7,8-Dimethyl-10-(D-ribo-2,3,4,5-tetrahydroxypentyl)isoalloxazine
7,8-Dimethyl-10-ribitylisoalloxazine
83-88-5
[VT106] RIBOFLAVIN
E101
Lactoflavin preparation
Lactoflavine
Lactoflavin
Riboflavin (substance)
Riboflavin [Chemical/Ingredient]
Riboflavin Drug Class
Riboflavin preparation
Riboflavina
Riboflavine preparation (product)
Riboflavine preparation
Riboflavine
Riboflavinum
riboflavin
Vitamin B 2
VITAMIN B A 02
Vitamin B2 preparation
Vitamin B2
Vitamin B<sub>2</sub> preparation
Vitamin B<sub>2</sub>
Vitamin B>2< preparation
Vitamin B>2<
Vitamin G preparation
vitamin G

External Source Codes: 
NCI Thesaurus Code C808 (see NCI Thesaurus info)
CAS Registry Number 83-88-5 (see NLM ChemIDplus info)
FDA UNII Code TLM2976OFR
NSC Code 33298 (see NCI DTP info)
PDQ Closed Trial Search ID 38330
PDQ Open Trial Search ID 38330 (check for NCI PDQ open clinical trial info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL AA AD AE AG AI AN BI BL CF CH CL CS CT EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UR MSH
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
CHEBI_ID CHEBI:17015 NCI
Chemical_Formula C17H20N4O6 NCI
Contributing_Source CRCH NCI
Contributing_Source FDA NCI
CTV3ID in3.. SNOMEDCT_US
CTV3ID X80RU SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 3147-2745 CSP
DRUG_CLASS_TYPE 2 VANDF
DX 19660101 MSH
EC deficiency:Riboflavin Deficiency MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
FDA_UNII_CODE TLM2976OFR DRUGBANK
FDA_UNII_CODE TLM2976OFR NDFRT
INFOODS RIBF NCI
LEVEL Ingredient NDFRT
LEVEL VA Class NDFRT
MDA 19990101 MSH
MESH_DEFINITION Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE. NDFRT
MESH_DUI D012256 NDFRT
MESH_NAME Riboflavin NDFRT
MESH_UI M0019064 NDFRT
Micronutrient Y NCI
MMR 20160531 MSH
MN D03.633.100.733.315.650 MSH
MN D03.633.300.507.650 MSH
MN D08.211.474.650 MSH
MN D23.767.405.650 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
MODULE_ID 731000124108 SNOMEDCT_US
MODULE_NAME US National Library of Medicine maintained module SNOMEDCT_US
NCI_THESAURUS_CODE C808 PDQ
NDFRT_KIND DRUG_KIND NDFRT
NDFRT_KIND INGREDIENT_KIND NDFRT
NUI N0000005897 NDFRT
NUI N0000029454 NDFRT
NUI N0000146013 NDFRT
NUI N0000146139 NDFRT
Nutrient Y NCI
ORIG_STY Drug/agent PDQ
PA D014803 MSH
PA D017319 MSH
PARENT_CLASS 427 VANDF
PID 1095 PDQ
RN TLM2976OFR MSH
RR 83-88-5 (Riboflavin) MSH
RXAUI 2074154 RXNORM
RXAUI 2075235 RXNORM
RXAUI 2629103 RXNORM
RXAUI 300543 RXNORM
RXAUI 3227792 RXNORM
RXAUI 3227793 RXNORM
RXAUI 3227794 RXNORM
RXAUI 3232264 RXNORM
RXAUI 3232281 RXNORM
RXAUI 3254160 RXNORM
RXAUI 3254161 RXNORM
RXAUI 3255689 RXNORM
RXAUI 3255716 RXNORM
RXAUI 3255769 RXNORM
RXAUI 3257953 RXNORM
RXAUI 3280087 RXNORM
RXAUI 3280091 RXNORM
RXAUI 4248719 RXNORM
RXAUI 5954615 RXNORM
RXCUI 1551666 RXNORM
RXCUI 9346 RXNORM
SID APRD00626 DRUGBANK
SID DB09358 DRUGBANK
SID EXPT02760 DRUGBANK
SID NUTR00010 DRUGBANK
SNOMEDID C-A404E SNOMEDCT_US
SNOMEDID F-BB320 SNOMEDCT_US
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SPL_SET_ID f8489a5b-72d1-4bb3-b686-8984c779dd66 MTHSPL
SPL_SET_ID fa02b240-62cd-4042-839e-a04d2f41d6b7 MTHSPL
SPL_SET_ID fb8eb411-0bf2-4ba8-ae9a-b08f113d54d7 MTHSPL
SPL_SET_ID ff83f5d0-7dec-4089-aafe-77e486d9d335 MTHSPL
SPL_SET_ID ffb770b4-8b6d-445c-9faa-8a61efd7d6b0 MTHSPL
SPL_SET_ID ffc79b35-c32a-4a36-a8b4-20e2a816c9de MTHSPL
SUBSET_MEMBER 900000000000497000~MAPTARGET~in3.. SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~X80RU SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~C-A404E SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~F-BB320 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T036408 MSH
TERMUI T036409 MSH
TERMUI T036410 MSH
TERMUI T036411 MSH
TH FDA SRS (2014) MSH
TH INN (19XX) MSH
TH NLM (1966) MSH
TH UNK (19XX) MSH
TH USP (19XX) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US
Unit mg NCI
US_Recommended_Intake Y NCI
USDA_ID 405 NCI
VAC VT106 NDFRT
VAC VT106 VANDF
VANDF_RECORD 50.416^228^Active/Master NDFRT
VANDF_RECORD 50.416^373^Active/Master NDFRT
VANDF_RECORD 50.605^424^Active/Master NDFRT
VANDF_RECORD 50.6^1878^Active/Master NDFRT
VUID 4017633 NDFRT
VUID 4017778 NDFRT
VUID 4021901 NDFRT

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0035527

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