skip navigation links
National Cancer Institute
Enterprise Vocabulary Services
Box
NCIm Version: 201808 (Browser Version 2.9, using LexEVS 6.5.1)
SearchBox Top
SearchBox Bottom
Rheumatic Fever (CUI C0035436) Suggest changes to this concept
Add to Cart

Terms & Properties

Concept Unique Identifier (CUI): C0035436

NCI Thesaurus Code: C34984  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An inflammatory disorder that follows infection with group A streptococcus. It affects the heart, joints, and subcutaneous tissues. It manifests with pericarditis, heart murmur, congestive heart failure, polyarthritis, subcutaneous nodules, and erythema marginatum. It is characterized by the formation of granulomatous lesions called Aschoff bodies usually in the heart tissue.

GARD Definition: Rheumatic fever is an inflammatory condition that may develop after infection with group A Streptococcus bacteria, such as strep throat or scarlet fever. It is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. Early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. Some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. It is not clear why some people who are infected with group A Streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. Treatment usually includes antibiotics and/or anti-inflammatory medications. - this information is from GARD/ORDR/NCATS.

NICHD Definition: An inflammatory disorder that follows infection with group A streptococcus. It may manifest with carditis, migratory polyarthritis, subcutaneous nodules, erythema marginatum, and chorea.

CSP Definition: febrile disease occurring as a delayed sequela of infections with group A hemolytic streptococci and characterized by multiple focal inflammatory lesions of the connective tissue structures, especially of the heart, blood vessels, and joints (polyarthritis), and by the presence of Aschoff bodies in the myocardium and skin.

MSH Definition: A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.

Synonyms & Abbreviations: (see Synonym Details)
Active rheumatic fever (disorder)
Active rheumatic fever
Acute Articular Rheumatisms
Acute Articular Rheumatism
Acute Rheumatic Arthritides
Acute rheumatic arthritis (disorder)
Acute Rheumatic Arthritis
Acute rheumatic attack
Acute rheumatic fever (I00-I02)
Acute Rheumatic Fevers
Acute rheumatic fever
Acute rheumatism
ARF - Acute rheumatic fever
ARF
Arthritides, Acute Rheumatic
Arthritis, Acute Rheumatic
Arthritis, Rheumatic, Acute
Articular Rheumatism, Acute
Articular Rheumatisms, Acute
Fever, Acute Rheumatic
Fever, Rheumatic
Fevers, Acute Rheumatic
Fevers, Rheumatic
Inflammatory rheumatism
Polyarthritis Rheumaticas
Polyarthritis Rheumatica
Rheumatic Arthritides, Acute
Rheumatic arthritis acute
Rheumatic Arthritis, Acute
Rheumatic Arthritis
Rheumatic fever (disorder)
Rheumatic Fever [Disease/Finding]
Rheumatic fever, active
RHEUMATIC FEVER, ACUTE
Rheumatic Fevers, Acute
Rheumatic Fevers
rheumatic fever
Rheumatism, Acute Articular
Rheumatism, Articular, Acute
RHEUMATISM, INFLAMMATORY
Rheumatisms, Acute Articular
RhF - Rheumatic fever

External Source Codes: 
NCI Thesaurus Code C34984 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AN Strep infect; rheum fever with heart dis, unspecified or specific = RHEUMATIC HEART DISEASE (IM) + the specific heart dis (IM or NIM), but not HEART DISEASES MSH
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH TM UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000020002 SNOMEDCT_US
CASE_SIGNIFICANCE_ID 900000000000448009 SNOMEDCT_US
CHARACTERISTIC_TYPE_ID 900000000000011006 SNOMEDCT_US
Contributing_Source NICHD NCI
CTV3ID G0... SNOMEDCT_US
CTV3ID XM0rI SNOMEDCT_US
CTV3ID XULRz SNOMEDCT_US
DC 1 MSH
DEFINITION_STATUS_ID 900000000000073002 SNOMEDCT_US
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0368-3578 CSP
DX 19660101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
EFFECTIVE_TIME 20050131 SNOMEDCT_US
EXTERNALLY_DEFINED N LNC
HAS_GARD_PAGE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2008-10-30T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin. NDFRT
MESH_DUI D012213 NDFRT
MESH_NAME Rheumatic Fever NDFRT
MESH_UI M0019009 NDFRT
MMR 20100625 MSH
MN C01.252.410.890.731 MSH
MN C05.550.114.843 MSH
MN C05.799.825 MSH
MODIFIER_ID 900000000000451002 SNOMEDCT_US
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Rheumatic Fever NCI
NUI N0000002629 NDFRT
PRIMARY_PATH 10039054$10003284$10023213$10028395$Rheumatic fever$Arthropathies NEC$Joint disorders$Musculoskeletal and connective tissue disorders MDR
PRIMARY_SOC 10028395 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 20.0 MDR
PT_IN_VERSION 20.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/5699/rheumatic-fever/resources/1 GARD
RXAUI 3111710 RXNORM
RXAUI 3111735 RXNORM
RXAUI 3221992 RXNORM
RXAUI 3232153 RXNORM
RXAUI 3232154 RXNORM
RXAUI 3232163 RXNORM
RXAUI 3232164 RXNORM
RXAUI 3286638 RXNORM
RXAUI 3605943 RXNORM
RXAUI 3606286 RXNORM
RXCUI 1023414 RXNORM
SMQ_TERM_ADDVERSION 16.1 MDR
SMQ_TERM_ADDVERSION 18.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 16.1 MDR
SMQ_TERM_LMVERSION 18.0 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 58718002 NDFRT
SNOMED_CID 81077008 NDFRT
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS I00 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~I00 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS I00 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS M06.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF ACUTE RHEUMATIC FEVER WITH VALVULITIS CHOOSE I01.1 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF AGE AT ONSET OF CLINICAL FINDING ON OR AFTER 1.0 YEAR AND IF AGE AT ONSET OF CLINICAL FINDING BEFORE 18.0 YEARS CHOOSE M08.00 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF RHEUMATIC FEVER NODULE CHOOSE M06.30 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF RHEUMATIC FEVER WITH HEART INVOLVEMENT CHOOSE I09.9 | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~IF RHEUMATIC PNEUMONIA CHOOSE J17 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447638001 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447639009 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~2 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~3 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~4 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 194708008 | Rheumatic fever with heart involvement | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 240041006 | Rheumatic fever nodule | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 445518008 | Age at onset of clinical finding (observable entity) | >= 1.0 year AND IFA 445518008 | Age at onset of clinical finding (observable entity) | < 18.0 years SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 7548000 | Rheumatic pneumonia | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~IFA 84871007 | Acute rheumatic fever with valvulitis | SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~OTHERWISE TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I00 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I01.1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~I09.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~J17 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M06.30 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M06.9 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~M08.00 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~ SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~G0... SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XM0rI SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~XULRz SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T036324 MSH
TERMUI T036325 MSH
TERMUI T036326 MSH
TERMUI T036327 MSH
TERMUI T036328 MSH
TERMUI T036329 MSH
TERMUI T727516 MSH
TERMUI T727517 MSH
TERMUI T752441 MSH
TH NLM (1992) MSH
TH NLM (1994) MSH
TH NLM (2010) MSH
TH NLM (2011) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0035436

Mainbox Bottom