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Reye Syndrome (CUI C0035400) Suggest changes to this concept
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Terms & Properties

Concept Unique Identifier (CUI): C0035400

NCI Thesaurus Code: C34983  (see NCI Thesaurus info)

Semantic Type: Disease or Syndrome

NCIt Definition: An acute and potentially fatal metabolic disorder characterized by cerebral edema, fatty liver and hypoglycemia. It occurs primarily in children and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use.

MEDLINEPLUS Definition: 

Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include

  • Nausea and vomiting
  • Listlessness
  • Personality change - such as irritability, combativeness or confusion
  • Delirium
  • Convulsions
  • Loss of consciousness

If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure.

The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients.

NIH: National Institute of Neurological Disorders and Stroke

NCI-GLOSS Definition: A rare disease that damages the brain and liver and causes death if not treated. It occurs most often in children younger than 15 years who have had a fever-causing virus, such as chickenpox or flu. Taking aspirin during a viral illness may increase the risk of Reye syndrome.

NICHD Definition: An acute and potentially fatal metabolic condition characterized by cerebral edema, fatty liver, and hypoglycemia. It occurs primarily in children, and has been associated with the use of aspirin for the treatment of viral infections. However, it can also occur in the absence of aspirin use.

CSP Definition: rare, acute, sometimes fatal disease of childhood, most often occurring as a sequel of varicella or a viral upper respiratory infection of childhood; marked by recurrent vomiting and elevated serum transaminase levels with distinctive changes in the liver and other viscera; an encephalopathic phase with acute brain swelling disturbances of consciousness and seizures may follow.

MSH Definition: A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.

Synonyms & Abbreviations: (see Synonym Details)
FATTY LIVER WITH ENCEPHALOPATHY
Reye Johnson Syndrome
Reye Syndrome [Disease/Finding]
REYE SYNDROME
Reye's encephalopathy
Reye's syndrome (disorder)
Reye's syndrome
Reye-Johnson Syndrome
REYES SYNDROME
RS
SYNDROME REYES

External Source Codes: 
NCI Thesaurus Code C34983 (see NCI Thesaurus info)

Other Properties: Property Definitions
Name Value Source
ACTIVE 1 SNOMEDCT_US
AQL BL CF CI CL CN CO DG DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RH RT SU TH UR VE VI MSH
CASE_SIGNIFICANCE_ID 900000000000017005 SNOMEDCT_US
CODE_FIRST (T39.0-), if salicylates-induced ICD10CM
Contributing_Source NICHD NCI
CTV3ID F11y0 SNOMEDCT_US
DATE_CREATED 07/01/1999 MEDLINEPLUS
DATE_CREATED 2013-01-09T00:04:00 GARD
DATE_LAST_MODIFIED 2013-01-09T00:04:00 GARD
DC 1 MSH
DEFINITION_STATUS_ID 900000000000074008 SNOMEDCT_US
DID 0944-8104 CSP
DISEASE_IDENTIFIER_ID 5631 GARD
DISEASE_IDENTIFIER_ID 5632 GARD
DISEASE_IDENTIFIER_ID 5633 GARD
DX 19770101 MSH
EFFECTIVE_TIME 20020131 SNOMEDCT_US
HAS_GARD_PAGE true GARD
HN 1998(1977) MSH
IAN DEFAULT ICD10
IDENTIFIER_TYPE_ID 1 GARD
IS_ACTIVE true GARD
IS_RARE true GARD
IS_SPANISH false GARD
LAST_REVIEW_DATE 2008-10-30T00:00:00 GARD
MDA 19990101 MSH
MESH_DEFINITION A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism. NDFRT
MESH_DUI D012202 NDFRT
MESH_NAME Reye Syndrome NDFRT
MESH_UI M0018992 NDFRT
MMR 20100625 MSH
MN C06.552.241.649 MSH
MN C10.228.140.163.780 MSH
MN C18.452.132.780 MSH
MP_HEALTH_TOPIC_URL https://www.nlm.nih.gov/medlineplus/reyesyndrome.html MEDLINEPLUS
MP_PRIMARY_INSTITUTE_URL National Institute of Neurological Disorders and Stroke http://www.ninds.nih.gov/ MEDLINEPLUS
NDFRT_KIND DISEASE_KIND NDFRT
NICHD_Hierarchy_Term Reye Syndrome NCI
NUI N0000002624 NDFRT
ORDER_NO 06512 ICD10CM
PM 1998; see REYE'S SYNDROME 1977-97 MSH
PRIMARY_PATH 10039012$10019833$10019654$10019805$Reye's syndrome$Hepatocellular damage and hepatitis NEC$Hepatic and hepatobiliary disorders$Hepatobiliary disorders MDR
PRIMARY_SOC 10019805 MDR
PT_IN_VERSION 10.0 MDR
PT_IN_VERSION 10.1 MDR
PT_IN_VERSION 11.0 MDR
PT_IN_VERSION 11.1 MDR
PT_IN_VERSION 12.0 MDR
PT_IN_VERSION 12.1 MDR
PT_IN_VERSION 13.0 MDR
PT_IN_VERSION 13.1 MDR
PT_IN_VERSION 14.0 MDR
PT_IN_VERSION 14.1 MDR
PT_IN_VERSION 15.0 MDR
PT_IN_VERSION 15.1 MDR
PT_IN_VERSION 16.0 MDR
PT_IN_VERSION 16.1 MDR
PT_IN_VERSION 17.0 MDR
PT_IN_VERSION 17.1 MDR
PT_IN_VERSION 18.0 MDR
PT_IN_VERSION 18.1 MDR
PT_IN_VERSION 19.0 MDR
PT_IN_VERSION 19.1 MDR
PT_IN_VERSION 8.0 MDR
PT_IN_VERSION 8.1 MDR
PT_IN_VERSION 9.0 MDR
PT_IN_VERSION 9.1 MDR
RARE_DISEASE_URL http://rarediseases.info.nih.gov/gard/7570/reye-syndrome/resources/1 GARD
RXAUI 3232093 RXNORM
RXAUI 3232094 RXNORM
RXAUI 3232097 RXNORM
RXAUI 3232100 RXNORM
RXAUI 3605815 RXNORM
RXCUI 1026604 RXNORM
SMQ_TERM_ADDVERSION 10.1 MDR
SMQ_TERM_ADDVERSION 8.0 MDR
SMQ_TERM_CAT A MDR
SMQ_TERM_LEVEL 4 MDR
SMQ_TERM_LEVEL 5 MDR
SMQ_TERM_LMVERSION 10.1 MDR
SMQ_TERM_LMVERSION 12.1 MDR
SMQ_TERM_SCOPE 2 MDR
SMQ_TERM_STATUS A MDR
SMQ_TERM_WEIGHT 0 MDR
SNOMED_CID 74351001 NDFRT
SNOMEDID DA-20050 SNOMEDCT_US
SUBSET_MEMBER 447562003~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPADVICE~ALWAYS G93.7 | POSSIBLE REQUIREMENT FOR AN EXTERNAL CAUSE CODE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 447562003~MAPTARGET~G93.7 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~CORRELATIONID~447561005 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPADVICE~ALWAYS G93.7 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPCATEGORYID~447637006 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPGROUP~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPPRIORITY~1 SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPRULE~TRUE SNOMEDCT_US
SUBSET_MEMBER 6011000124106~MAPTARGET~G93.7 SNOMEDCT_US
SUBSET_MEMBER 900000000000497000~MAPTARGET~F11y0 SNOMEDCT_US
SUBSET_MEMBER 900000000000498005~MAPTARGET~DA-20050 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000508004~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000548007 SNOMEDCT_US
SUBSET_MEMBER 900000000000509007~ACCEPTABILITYID~900000000000549004 SNOMEDCT_US
TERMUI T036302 MSH
TERMUI T036303 MSH
TERMUI T370081 MSH
TERMUI T727513 MSH
TH NLM (1975) MSH
TH NLM (1998) MSH
TH NLM (2000) MSH
TH NLM (2011) MSH
TH ORD (2010) MSH
TYPE_ID 900000000000003001 SNOMEDCT_US
TYPE_ID 900000000000013009 SNOMEDCT_US

Additional Concept Data:  (none)

URL to Bookmark: https://ncim-stage.nci.nih.gov/ncimbrowser/ConceptReport.jsp?dictionary=NCI Metathesaurus&code=C0035400

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